Do you have any queries?

or Call us now at 9982-782-555

back-arrow-image Search Health Packages, Tests & More

Preventive Healthcare

Everything You Need to Know About Buerger’s Disease




Living with Buerger's disease can be intimidating, but understanding it is the first step to manage it effectively. This guide to Buerger's disease provides essential insight into the disease, covering it's symptoms, causes, diagnosis, treatment, and self-care strategies. Whether you are recently diagnosed or seeking more information, this full resource aims to give you knowledge and support to navigate your trip with Buerger's disease.

What Is Buerger’s Disease?

Buerger's disease, or thromboangiitis obliterans, is a non-atherosclerotic (group of abnormalities in the coronary arteries) inflammatory disease that primarily affects small and medium-sized arteries, commonly in the limbs.

This results in progressive vessel occlusion (cerebral vessels become progressively occluded, leading to insufficient perfusion of brain tissue), leading to ischemia (blood flow (and thus oxygen) is restricted or reduced in a body part) and tissue damage, which is often associated with smoking.     

What Are The Symptoms Of Buerger’s Disease?

Common symptoms of Buerger’s disease include:

  1. Ischemic rest pain : Severe pain in the hands or feet, which often occurs during taking a rest due to Buerger's disease.
  2. Claudication: Muscle cramps due to insufficient blood flow, usually in the calf muscle, are a symptom of Buerger's disease.
  3. Raynaud's phenomenon: Changes in the color of the skin of the fingers or toes, appearing as red, blue, or pale discoloration, are also important symptoms of Buerger's disease to watch out for.
  4. Numbness or tingling: Numbness or tingling in the fingers or toes caused by Buerger's disease.
  5. Ulcerations: Open sores or wounds on the toes, feet, or fingers, often due to poor circulation, may indicate Buerger's disease.

What Causes Buerger’s Disease?

Buerger's disease is caused by inflammation in the small and medium-sized blood vessels. The exact Buerger's disease cause remains unclear, but several factors can contribute to its development.

Some potential contributing Buerger's disease causes include:

  1. Tobacco consumption, particularly smoking, is the main risk factor.
  2. Genetic factors may play a role, as the disease is more common in certain ethnic groups.
  3. Abnormalities of the immune system leading to inflammation of the blood vessels are believed to be the cause.
  4. Some researchers believe that Buerger's disease may result from an abnormal reaction to tobacco or other environmental exposures.

What Are The Risk Factors For Buerger’s Disease?

Common risk factors for Buerger’s disease include:

  • Smoking: Smoking is the most important risk factor for Burger's disease, and almost all those affected are current or former smokers.
  • Age: Buerger’s disease usuallyoccurs before the age of 50.
  • Arterial occlusions: Presence of infrapopliteal arterial occlusions (a condition that can lead to critical limb ischaemia (CLI), a potentially life-threatening disease affecting the limbs), especially in the lower limbs.
  • Limb involvement: The risk increases either with involvement of the upper limb or with phlebitis migrans, a form of migratory thrombophlebitis.
  • Other risk factors: Other risk factors of Buerger's disease may includegenetic predisposition, autoimmune response, or hypersensitivity to tobacco components.

What Are The Complications Of Buerger’s Disease?

Complications of Buerger’s disease include:

  • Gangrene: Tissue death due to lack of blood flow, leading to blackening and decay.
  • Ulcerations: Open sores or ulcers may develop on the fingers and toes, which are particularly susceptible to infection.
  • Infection: Secondary infections can develop due to Buerger’s disease in the ulcerated areas, which can lead to serious complications.
  • Amputation: In severe cases, affected fingers or limbs may need to be surgically removed.
  • Systemic complications such as occlusion of coronary, splenic, renal, or mesenteric arteries may arise rarely.

How Is Buerger’s Disease Diagnosed?

Buerger’s disease is diagnosed through a combination of clinical assessments, like medical history review, and diagnostic tests:

  • Clinical Examination: The diagnosis of Buerger's disease usually begins with a thorough clinical examination, focusing on symptoms such as ischemic ischemic rest pain, claudication, and characteristic skin changes.
  • Medical history: A detailed history of Buerger's disease, including smoking habits and other Buerger's disease risk factors, helps in making the diagnosis.
  • Physical Examination: Examination may reveal decreased or absent pulses, cold extremities, and signs of tissue ischemia, aiding in the diagnosis.
  • Differential Diagnosis: Buerger's disease must be differentiated from other conditions causing peripheral vascular disease, such as atherosclerosis and vasculitis.

What Tests Will Be Done To Diagnose Buerger’s Disease?

For Buerger's disease diagnosis, several tests may be conducted:

  1. Vascular Tests: Buerger's tests assess the blood flow and may include Doppler ultrasound to evaluate arterial blood flow velocity and waveform characteristics.
  2. Imaging Studies: Angiography or magnetic resonance angiography (MRA) may be performed to visualize blood vessels and detect any abnormalities, such as arterial blockages.
  3. Laboratory Tests: While there are no specific buerger tests for daignoses, a comprehensive serology may be performed to rule out other conditions.
  4. Urine Test: A urine test may also be performed to assess kidney function and rule out other possible causes of buergers disease symptoms.

How Is Buerger’s Disease Treated?

Buerger's disease treatment includes:

  • Smoking Cessation: Immediate cessation of tobacco use is crucial to halt Buerger's disease progression.
  • Medications: Antiplatelet agents and vasodilators may be prescribed to improve the blood flow and manage Buerger's disease symptoms.
  • Surgery: In severe cases of Buerger's disease, surgical intervention such as sympathectomy or bypass grafts may be required to restore blood flow.
  • Wound care: Ulcer management and wound care are essential for Buerger's disease treatment disease to prevent infection and tissue damage.

What Medications Are Used For Buerger’s Disease?

Medications commonly used for Buerger’s disease include:

  1. Vasodilators: Vasodilators such as calcium channel blockers, can be used to improve the blood flow.
  2. Antiplatelet Agents: Anti-platelet agents Like cilostazol and clopidogrel, are used to prevent the platelet aggregation and improve circulation.
  3. Pentoxifylline: Pentoxifylline a medication that improves blood flow by decreasing its viscosity and enhancing its ability to flow through the blood vessels.
  4. Prostacyclin and Prostaglandin Derivatives: May also be prescribed to improve the blood flow and Buerger's disease.

What Treatments Are Used For Buerger’s Disease?  

Treatment approaches for Buerger’s disease include:

Lifestyle Changes

  • Cessation of tobacco use: Complete discontinuation of all forms of tobacco, including cigarettes, electronic cigarettes, vaping, and marijuana, is imperative.


  • Antihypertensive agents: Medications to enhance blood flow by reducing blood pressure
  • Antiplatelet therapy: Administration of aspirin to prevent thrombus formation
  • Endothelin receptor antagonist: Use of bosentan (Tracleer) for severe cases to augment blood flow

Therapeutic Interventions

  • Intermittent pneumatic compression: Application of periodic mechanical pressure to the affected limbs to improve circulation

Surgical Management

  • Amputation: Surgical removal of necrotic or severely infected limbs in advanced cases.

Adjunctive Measures

  • Regular physical activity: Approved exercises to promote vascular health
  • Dermal surveillance: Routine inspection and care of skin to prevent and manage infections
  • Oral hygiene maintenance: Regular dental check-ups to mitigate the risk of periodontal disease
  • Avoidance of secondhand smoke: Steering clear of all forms of passive smoke exposure

What Are The Side Effects Of The Treatment?

Side effects of treatments can vary depending on the specific medication or therapy used.

Common side effects of Buerger's disease may include:

  • Gastrointestinal Disturbances: Such as nausea, vomiting, diarrhoea, or constipation because of Buerger's disease.
  • Cardiovascular Effects: Including changes in blood pressure or heart rate.
  • Hematological Abnormalities: Such as anemia, leukopenia, or thrombocytopenia.
  • Neurological Symptoms: Such as dizziness, headache, or neuropathy.
  • Dermatological Reactions: Such as rash, itching, or skin irritation.
  • Musculoskeletal Complaints: Such as muscle weakness, joint pain, or bone pain.
  • Metabolic Effects: Including changes in glucose levels, electrolyte imbalances, or weight gain/loss.
  • Psychological Effects: Such as mood changes, anxiety, or depression.

What Is The Outlook For Buerger’s Disease?

For individuals with Buerger's disease, the outlook can be challenging, especially without tobacco cessation. However, quitting smoking and proper management can improve symptoms and slow disease progression. Supportive care and lifestyle changes, coupled with medical interventions, offer hope for a better quality of life and reduce Buerger's disease complications.

How Do I Take Care Of Myself?

To manage Buerger's disease, it's crucial to cease tobacco use completely. Follow doctors' recommendations for self-care. Adhere to a healthy lifestyle, including regular exercise and a balanced diet. Seek medical attention for any complications promptly. Surgical intervention may be necessary for severe cases of Buerger's disease.


In conclusion, understanding Buerger’s Disease is crucial for effectively managing its symptoms and improving quality of life. From recognizing early signs of Buerger's disease to seeking appropriate medical care and adopting lifestyle changes like smoking cessation, self-care plays a vital role. Metropolis Labs offers reliable blood testing services, including Buerger's disease pathology tests essential for diagnosing and monitoring Buerger’s Disease. With their convenient at-home sample collection and advanced diagnostic facilities, Metropolis Labs ensures accurate results and seamless healthcare experiences for individuals managing this condition.

To learn more about Metropolis Labs and their comprehensive pathology services, visit Metropolis Labs.

Talk to our health advisor

Book Now


Your email address will not be published. Required fields are marked *

Popular Tests

Choose from our frequently booked blood tests

TruHealth Packages

View More

Choose from our wide range of TruHealth Package and Health Checkups

View More

Do you have any queries?