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Cyclic Citrullinated Peptide Antibody (CCP Antibody) Serum Test

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CCP Antibody Test Overview

Rheumatoid Arthritis (RA) is an autoimmune disease which affects joints. Patients are categorized basis phase of disease i.e., early and those with clinical manifestations (joint erosion, interstitial lung disease, or cardiovascular). Delayed diagnosis of RA is associated with joint disease and poor outcomes.
Anti CCP antibodies are useful in early diagnosis of patients suspected of Rheumatoid arthritis.  False positive results are uncommon as compared to RF. A subset of patients called seronegative Rheumatoid arthritis will be negative for RF & Anti CCP antibodies, they can be diagnosed clinically

The CCP Antibody serum test measures the presence of CCP antibodies in the blood. These CCP antibodies are a type of autoantibodies that are produced by the immune system and can affect healthy tissues. They usually affect the healthy tissues in the joints.

Thus, this test is used to diagnose rheumatoid arthritis (RA) and its severity. RA is a chronic, inflammatory, and autoimmune disease of the bones that mainly affects the hands and feet, thereby causing pain, swelling, and stiffness in the joints.

The presence of CCP antibodies confirms RA, and it’s usually not found in people who don’t have this disease. The CCP antibodies test is often done along with the rheumatoid factor (RF) test, but the RF can even be found in healthy people. Thus, the CCP test provides a more accurate diagnosis of the disease.

People with the following symptoms should do the CCP Antibody Serum Test:

If you have any of these symptoms of rheumatoid arthritis, then you need to get this test done:

  • Low-grade fever
  • Joint, back, or muscle pain
  • Stiffness of the joints, especially in the morning
  • Fatigue
  • Joint swelling, tenderness, or weakness
  • Malaise
  • Lumps or redness of the skin
  • Bump on fingers
  • Sensation of pins and needles
  • Dry mouth
  • Flare
  • Physical deformity
  • Swelling of hands.

Written by: Dr Mahak Sharma, MBBS, MD, Dept. of Heamatology 

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Cyclic Citrullinated Peptide Antibody (CCP Antibody) Serum Test Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Cyclic Citrullinated Peptide Antibody (CCP Antibody) Serum Test with a clear pricing structure.

The Cyclic Citrullinated Peptide Antibody (CCP Antibody) Serum Test Price in Mumbai is ₹ 1,670 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

ccp antibody test is prescribed to understand the inflammatory status of the blood vessels. This gives a more detailed idea of the risk of heart diseases than the routine cholesterol screening. This may be done in cases of :

  • Family history of early age heart diseases.
  • LDL levels are found to be high despite medication
  • Family history of hypercholesterolemia
  • Blood vessel diseases with normal triglyceride and total cholesterol levels
  • Self history of heart diseases with or without surgery. 
  • To diagnose deficiencies of Apo-A1 and Apo-B which may be genetic.

The CCP Antibody serum test is done to:

  • Diagnose rheumatoid arthritis
  • Estimate the severity of rheumatoid arthritis disease
  • Differentiate RA disease from other inflammatory arthritis or connective tissue diseases.

It is a comprehensive profile that comprises of four tests. ccp antibody test measures the amount of apolipoprotein (a), apolipoprotein B, ratio of  Apo-B/Apo-A, and Lipoprotein-A in the blood. This is a predictor of the risk of heart diseases.

This test measures the presence of CCP antibodies in the blood of patients with or estimated to have rheumatoid arthritis.

During ccp antibody test blood sample is taken from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a  little sting when the needle goes in or out. This usually takes less than five minutes.

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20 units/ml is considered the normal level of CCP antibodies. Test results above 20 units/ml are considered to be positive.

Apo A high levels of Apo A may reduce the risk of heart diseases, strokes and peripheral vascular disorders. Low levels may increase the risk of heart attacks and stroke. Low levels may also occur due to certain inherited apolipoprotein deficiencies.
Apo B high levels can lead to cholesterol being deposited in the arterial walls which causes thickening or clogging of the arterial walls also known as "atherosclerosis". This disrupts the flow of blood to the heart and other vital organs. This increases the risk of heart diseases, strokes, and other peripheral arterial diseases. Low levels may mean reduced risk of heart diseases. Low levels may also occur due to Apo-B deficiencies as seen in Tangier's disease or fish eye disease.
High B/A1 ratio increases the risk of heart diseases. Low ratio may reduce the risk of cardiac diseases and stroke.
High Lp-a levels also contribute to thickening of arteries and reduced blood supply. Certain conditions may contribute to high Lp-a  levels such as uncontrolled type 2 diabetes, chronic kidney disorders, hypothyroidism and certain hormonal disorders.  Hence, the aim should be to keep the Lp-a low or within normal levels.
Apolipoprotein Profile being a more specific test gives a clearer picture of the risk of heart diseases as compared to routine cholesterol tests.

It is conducted to check the presence of CCP antibodies in the patient’s blood to diagnose RA.

The blood sample is used for this test. The healthcare provider ties an elastic band on the upper arm and will ask you to tighten the fist. Then, the skin is disinfected with alcohol and a needle is inserted into the vein above your elbow to collect the blood. The blood is then poured into the test tube for further testing and in the meanwhile, you are told to fold the elbow, and then a band-aid is placed at that point.

The CPP antibody test can also come positive in the case of the following diseases:

  • Osteoarthritis
  • Chronic liver disease
  • SLE (Systemic lupus erythematosus)
  • Psoriatic arthritis
  • Seronegative arthritis
  • Sjogren's syndrome
  • Systemic sclerosis. 

A blood sample is taken for the test, just like other tests. But, you may feel dizzy, lightheaded, or have soreness at the site of blood collection.

In addition to the CPP antibody test, the doctor may suggest the following tests as sometimes it’s difficult to detect the disease in its early stages:

  • RF test
  • X-ray of joints
  • Erythrocyte sedimentation rate (ESR)
  • C-reactive protein
  • Antinuclear antibody
  • Synovial fluid analysis.

It is the most common form of arthritis in which the protective cartilage that surrounds the joints wears down or changes in structure.

Connective tissue disorders are a type of autoimmune disease like rheumatoid arthritis, scleroderma, lupus, microscopic polyangiitis, Marfan syndrome, Churg-Strauss syndrome, polymyositis/dermatomyositis and Granulomatosis with polyangiitis (GPA).

It’s a group of arthritis that shows similar symptoms to rheumatoid arthritis such as joint pains, swelling, and tenderness in the joints along with morning stiffness that lasts for almost an hour.

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