Bilirubin Total (Direct and Indirect) Test60+ booked in last 3 days
Bilirubin is a yellowish pigment found in the red blood cells, which is then broken down and carried by the liver for disposal. This process thus consists of two parts. In the first part after the red blood cells are broken down, the bilirubin is bound to a protein (albumin) in the blood. This is known as unconjugated or direct bilirubin. In the second part, liver then converts the bilirubin into a form that can be excreted. This is known as conjugated or direct bilirubin. Bilirubin total, direct and indirect serum is a blood test used to measure the amount of direct as well as indirect bilirubin in the blood.
Frequently Asked Questions
This test is advised to patients with jaundice (yellowish pigmentation of the eyes and the skin), abdominal pain and tenderness, nausea, and vomiting.
The causes of high unconjugated bilirubin are pre-hepatic destruction of RBC for e.g., haemolytic anaemia, large hematoma, megaloblastic anaemia
The causes high conjugated bilirubin include hepatitis due to alcohol, infection, drug reaction, autoimmune disorders and post hepatic causes can be gall stones, pancreatic or gall bladder cancer
This test measures the total, direct and indirect bilirubin levels in the blood.
The blood sample is taken from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.
High total bilirubin levels indicate either that the RBCs are being broken down at an abnormal rate or that the liver is not breaking down the bilirubin properly. This may occur due to jaundice, anaemia's or liver conditions like cirrhosis, ascites, hepatitis, or certain drug toxicities.
High bilirubin direct levels indicate problems in liver affecting the bilirubin disposal. This may occur due to jaundice, or liver conditions. High direct bilirubin levels may also occur due to certain blockages like gall stones or certain pancreatic issues.
High bilirubin may also occur due to sickle cell or other types of anaemia. Gilbert's syndrome is a condition leading to faulty enzyme that processes the bilirubin leading to high bilirubin levels. All these require further clinical correlation.
Low bilirubin levels are usually not harmful.
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