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C-Reactive Protein (CRP)

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Test Details in Brief

Also Known As C Reactive Protein Test, Serum CRP Test. Plasma CRP Test.
Purpose To measure levels of inflammation in the body, which can indicate a variety of conditions, such as infection, autoimmune diseases, and cancers.
Preparation No Special preparation.
Fasting Overnight fasting is preferred.
Reporting Time <24 Hour
Cost 550

C Reactive Protein Test Overview

C-Reactive Protein is an acute phase reactant in inflammation. It is useful for the detection and evaluation of infection, sepsis, tissue injury, inflammatory disorders and associated diseases. It is a non-specific marker and should be interpreted with caution. CRP protein is synthesized in the liver and released into the blood when there is inflammation in the body. Whenever you get hurt or infected by a virus or bacteria, your immune system gets activated. The activation releases inflammatory cells and cytokines. These cells engulf the virus or bacteria and lead to pain, swelling, redness, or flare. Some inflammations, however, cannot be visualized by the naked eye, such as the joints. When your joints get hurt or inflamed, your liver releases CRP. Under normal conditions, your body has low levels of CRP in the blood. But during inflammation, there may be moderate to severe elevation. A CRP test helps to detect this.

CRP test measures the level of C-reactive protein released by your liver in the bloodstream. If your doctor suspects that you have inflammation in your body, they may ask you to get your C-reactive protein level checked. It is not a specific test as it does not point out any specified inflammation. But it indicates that there is some inflammation in your body.

Written by: Dr Vishal Wadhwa M.D, D.N.B Microbiology, Medical Affairs

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C-Reactive Protein (CRP) Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the C-Reactive Protein (CRP) with a clear pricing structure.

The C-Reactive Protein (CRP) Price in Mumbai is ₹ 550 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

CRP test is done to assess presence of inflammation which results from infection, autoimmune diseases and injury which are common causes of unexplained fever, and joint pains
Serial measurements over days can provide useful information about the level & severity of the condition

The CRP test is performed to diagnose or monitor acute or chronic conditions that lead to inflammation in the body, such as rheumatoid arthritis, SLE, heart disease, IBS, sepsis, etc.

CRP test measures level of CRP in patients blood

CRP test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer. 

A healthcare provider will take your blood sample. An elastic band will be tightly tied to the upper arm. You will be asked to tighten your fist. Next, your skin gets disinfected with cotton soaked in alcohol. The healthcare provider will then insert a needle into your vein just above your elbow to collect blood. The blood will then be poured into a serum separator tube. You may feel a prick when the needle enters and exits your vein. The healthcare provider will put clean cotton over the punctured area and ask you to fold your elbow and hold it for a minute or two. A bandaid will be used to cover the punctured wound.

A high CRP levels are a non-specific indicator of inflammation & injury. Results should be interpreted in light of clinical history of the patient and results of other biomarkers. 
A low CRP result, despite inflammation, can occur in patients with liver disease

A moderately high CRP test could be due to the following conditions - SLE, Heart attack, Inflammation of the pancreas, or Inflammation of the lung.

  • A marked high CRP test is associated with Acute Bacterial Infection, Viral Infection, Systemic inflammation of the blood vessels, or Trauma.
  • A severely high CRP test is majorly associated with acute bacterial infection.
  • After having a high CRP test, you may go for a retest post-treatment to monitor your CRP levels. A decreasing value means that the treatment is working for you.
  • High-sensitivity CRP levels of less than 2 mg/L mean a lower risk of heart disease.
  • High-sensitivity CRP levels of more than or equal to 2 mg/L mean a higher risk of heart disease.

There is no preparation required for the CRP test.

CRP is usually measured in mg/L. Some laboratories measure it in mg/dL. The values are as given below:

Normal: Less than 0.9 mg/dL

High: 0.3 to 1.0 mg/dL

Moderately high: 1 to 10 mg/dL

Severely high: More than 50 mg/dL

The following factors affect a CRP test -

  • Obesity
  • Depression
  • Lack of sleep
  • Pregnancy
  • Estrogen-based medications like birth control pills
  • Chronic conditions like autoimmune diseases
  • Common cold
  • Smoking
  • Gingivitis
  • Recent injury
  • Diabetes

Other tests that can be prescribed along with the CRP test depend upon the condition for which a CRP test has been recommended by your doctor. For example, a hs-CRP test (high-sensitivity C-reactive Protein test) may be prescribed for diagnosing the risk of heart disease. Consult your doctor for more information.

A CRP test is done to:

• Diagnose inflammatory conditions like arthritis, infection, or cancer

• Check if the treatment for a previous inflammatory condition is working or not

CRP test is usually done to diagnose or rule out certain conditions. People who have symptoms of the following conditions should go for a CRP test:

  • Fungal infection
  • Inflammatory Bowel Disease (IBS)
  • Sepsis
  • Arthritis
  • Heart disease
  • Risk of second heart attack
  • Rheumatic fever
  • SLE (Systemic lupus erythematosus)
  • Rheumatoid Arthritis
  • Pelvis Inflammatory Disease
  • Cancer
  • Organ or tissue injury
  • Inflammation of the lining of the heart (Pericarditis)
  • Osteomyelitis

Your doctor may advise you to go for a CRP test if you have the following symptoms:

  • Fever with chills
  • Rapid breathing
  • Rapid heart rate
  • Nausea
  • Vomiting
  • Unexplained exhaustion
  • Pain
  • Headache
  • Difficulty in sleeping
  • Unexplained weight loss
  • Indigestion
  • Loss of appetite
  • Muscular stiffness
  • Muscular soreness and weakness
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