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HLA B27 Test (Human Leucocyte Antigen B27) in Malad

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HLAB27 Test Overview

Human leukocyte antigen HLA-B27 is a MHC (major histocompatibility complex) class I surface antigen encoded by the B locus on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis. HLA B27 is considered to be an important criterion for the classification of axial spondyloarthropathies & helps in establishing early diagnosis of ankylosing spondyloarthropathies before the development of irreversible deformities. HLA-B27 is present in approximately 89% of patients with ankylosing spondylitis, 79% of patients with Reiter syndrome, and 42% of patients with juvenile rheumatoid arthritis. However, it is not diagnostic for these disorders. Approximately 8% of the normal population carries the HLA-B27 antigen.

Written by: Dr. Sanjay Gohil, MBBS, M.D, Dept. of Haematology 







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