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HLA B27 Test (Human Leucocyte Antigen B27)

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HLAB27 Test Overview

Human leukocyte antigen HLA-B27 is a MHC (major histocompatibility complex) class I surface antigen encoded by the B locus on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis. HLA B27 is considered to be an important criterion for the classification of axial spondyloarthropathies & helps in establishing early diagnosis of ankylosing spondyloarthropathies before the development of irreversible deformities. HLA-B27 is present in approximately 89% of patients with ankylosing spondylitis, 79% of patients with Reiter syndrome, and 42% of patients with juvenile rheumatoid arthritis. However, it is not diagnostic for these disorders. Approximately 8% of the normal population carries the HLA-B27 antigen.

Written by: Dr. Sanjay Gohil, MBBS, M.D, Dept. of Haematology 

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HLA B27 Test (Human Leucocyte Antigen B27) Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the HLA B27 Test (Human Leucocyte Antigen B27) with a clear pricing structure.

The HLA B27 Test (Human Leucocyte Antigen B27) Price in Mumbai is ₹ 2,450 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

A doctor may order an HLA B27 test to monitor how far an autoimmune disease has progressed in the body. This protein's presence is linked with several autoimmune and immune-mediated problems, such as:

  • Ankylosing spondylitis: It is the culprit behind inflammation in the bones of the spine.
  • Reactive arthritis: It is known to cause inflammation in the joints, eyes and urethra. It may also cause lesions on the skin.
  • Anterior Uveitis: It can cause swelling and irritation in the eye.

HLAB27 test helps determine whether you have human leukocyte antigen B27 (HLA-B27) on the surface of your cells and in turn it helps assess the likelihood that you may be suffering from an autoimmune disorder.

HLAB27 test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer. A healthcare provider will draw a sample of blood from the arm of the patient. They will place an elastic around the upper portion of the arm. Then the patient will need to make a fist. They will then disinfect the site from which the sample is to be drawn. They will use a clean needle to draw the required quantity of blood in a test tube or a vial.

A negative test means that there is no HLA-B27 in your blood. It is important to note that a negative HLAB27 test does not mean that you may not have an autoimmune disorder. Your doctor will make a final diagnosis basis the symptoms that you have, and test results and he may order more tests if needed. A positive test results indicates presence of HLA-B27 in your blood. If you have symptoms or signs of spondyloarthritis, a positive HLA-B27 test may help confirm the diagnosis. However, HLA-B27 is found in some normal people and does not always mean you have a disease.

The diseases which are associated with HLA B27 tend to manifest more frequently in men but women are also susceptible. But the symptoms related to the diseases may be less in women than in men.

  • Human Leukocyte Antigen B27
  • Ankylosing Spondylitis HLA
  • Doctors recommend the HLA B27 blood test along with other blood tests, imaging tests or urine tests to diagnose several autoimmune diseases.
  • Symptoms like pain in the joints, stiffness or swelling along the spine, chest and neck, inflammation in the joints, lesions on the skin, and repeated inflammation of the eye may also compel a doctor to recommend this test.
  • Doctors may even recommend HLA antigen tests if a patient is undergoing a transplant of kidney or bone marrow. They can help establish a good match between the patient and the donor.
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