HLA B27 Test

What Does the HLA B27 Test (Human Leucocyte Antigen B27) Measure?

The HLA B27 blood test serves several important diagnostic purposes:

• Detects protein presence: The test identifies whether the HLA-B27 protein exists on your white blood cells.
• Indicates genetic predisposition: A positive result shows you carry a genetic marker linked to increased risk of certain autoimmune diseases.
• Provides diagnostic support: For people with symptoms, a positive result helps doctors confirm suspected diagnoses like ankylosing spondylitis.
• Offers risk assessment: The test helps evaluate your likelihood of developing specific inflammatory conditions.
• Supports treatment planning: Results guide doctors in choosing appropriate treatment approaches for autoimmune disorders.

HLA B27 Test (Human Leucocyte Antigen B27): Who Needs It and Why It's Done

What Symptoms May Call for an HLA B27 Test (Human Leucocyte Antigen B27)?

Your doctor may recommend this test if you experience persistent symptoms that suggest autoimmune conditions:

• Chronic lower back pain and stiffness, especially worse in the morning
• Joint pain and swelling in the hips, knees, or ankles
• Eye inflammation causing pain, redness, and blurred vision (uveitis)
• Swelling of entire fingers or toes (sausage-like appearance)
• Heel or foot sole pain that doesn't improve
• Unexplained skin rashes or digestive problems
• Neck stiffness and reduced mobility

Who Should Get an HLA B27 Test (Human Leucocyte Antigen B27)?

This test is specifically recommended for certain groups of people:

• Symptomatic patients: People experiencing chronic inflammatory symptoms that suggest spondyloarthropathy.
• Family history cases: Individuals with close relatives diagnosed with HLA-B27-associated diseases who now show symptoms.
• Diagnostic clarification: Patients need help distinguishing between different types of arthritis.
• Risk assessment: People with unexplained chronic inflammation when other tests are inconclusive.

Why Is an HLA B27 Test (Human Leucocyte Antigen B27) Done?

This test helps doctors diagnose or rule out specific autoimmune disorders, most notably ankylosing spondylitis and related spondyloarthropathies. A positive result significantly strengthens the likelihood of these conditions when combined with your symptoms.

Importance of an HLA B27 Test (Human Leucocyte Antigen B27)

The HLA B27 blood test plays a crucial role in early diagnosis and treatment planning. While having the HLA-B27 antigen doesn't guarantee you'll develop a disease, its presence in someone with typical symptoms makes diagnosis much more certain. Early and accurate diagnosis of conditions like ankylosing spondylitis allows for prompt treatment with appropriate medications and physical therapy.

This early intervention helps manage pain, reduce inflammation, slow disease progression, and prevent long-term joint damage, significantly improving your quality of life and mobility.

HLA B27 Test (Human Leucocyte Antigen B27) Booking & Reports – Metropolis Healthcare India

How to Book an HLA B27 Test (Human Leucocyte Antigen B27)?

1. Simple Online Booking
   Booking can be done through the Metropolis Healthcare App or website. Select 'HLA B27 Test (Human Leucocyte Antigen B27)', choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab.
2. Safe Home Sample Collection
   Our trained phlebotomists ensure the timely collection of your sample while strictly following all safety and hygiene protocols.
3. Sample Tracking Updates
   Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website.
4. Accurate Laboratory Testing
   Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results.
5. Quick & Easy Reports
   Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app.

Is Home Sample Collection for the HLA B27 Test (Human Leucocyte Antigen B27) Available Near You?

Yes, home sample collection for the HLA B27 test is widely available across India through Metropolis Healthcare. Our trained phlebotomists bring laboratory testing to your doorstep with complete convenience and safety. They visit your home at your preferred time, following strict hygiene protocols to collect your blood sample. It eliminates your need to visit a lab, making healthcare more accessible with accurate results.

How Long Does It Take to Get an HLA B27 Test (Human Leucocyte Antigen B27) Report?

Reports are usually available within the next day by 5:00 PM once the sample reaches the lab.

Where Can I See or Get HLA B27 Test (Human Leucocyte Antigen B27) Results?

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab.

Interpreting HLA B27 Test (Human Leucocyte Antigen B27) Results

What Your HLA B27 Test (Human Leucocyte Antigen B27) Results May Indicate

The following table explains what your HLA B27 test results mean and their clinical significance:

Conditions that May Affect HLA B27 Test (Human Leucocyte Antigen B27) Accuracy

Several factors can influence your HLA B27 blood test results and should be discussed with your doctor:

• Cross-reactivity with HLA B7: HLA B7 antigen can sometimes give false positive results, requiring confirmation with additional testing.
• Borderline results: Results near the cut-off value may need molecular confirmation through PCR testing.
• Technical limitations: The flow cytometry method has inherent variability that may require repeat testing in borderline cases.
• Sample quality issues: Haemolysed, lipaemic, or clotted blood samples can affect test accuracy.
• Storage conditions: Improper sample storage or transportation can impact results.

How Is an HLA B27 Test (Human Leucocyte Antigen B27) Done?

The HLA B27 test follows a systematic process to ensure accurate results:

• Sample collection: A healthcare professional draws blood from a vein in your arm using standard venipuncture technique.
• Sample preparation: Your blood sample is collected in an EDTA tube to prevent clotting.
• Laboratory processing: The sample is analysed using flow cytometry to detect HLA-B27 proteins on white blood cells.
• Result interpretation: Laboratory technicians determine whether the antigen is present or absent.
• Quality control: Results undergo verification to ensure accuracy before reporting.

How Should You Prepare for an HLA B27 Test (Human Leucocyte Antigen B27)?

Preparing for your HLA B27 test is straightforward and requires minimal effort:

• No fasting required: You can eat and drink normally before the test.
• Continue medications: Take all prescribed medications as usual unless your doctor advises otherwise.
• Stay hydrated: Drinking adequate water makes blood collection easier.
• Wear comfortable clothing: Choose clothes with sleeves that can be easily rolled up.
• Inform about medications: Tell your doctor about any medicines, herbs, or supplements you're taking.
• Bring required documents: Carry your prescription and any previous test reports.

Diseases that an HLA B27 Test (Human Leucocyte Antigen B27) Can Help Detect

The HLA B27 test assists in diagnosing several autoimmune and inflammatory conditions:

• Ankylosing spondylitis: Chronic inflammatory arthritis affecting the spine and sacroiliac joints
• Reactive arthritis: Joint inflammation following bacterial infections in other parts of the body
• Psoriatic arthritis: Inflammatory arthritis associated with the psoriasis skin condition
• Inflammatory bowel disease arthritis: Joint inflammation linked to Crohn's disease or ulcerative colitis
• Acute anterior uveitis: Painful eye inflammation affecting the front part of the eye
• Juvenile idiopathic arthritis: Childhood arthritis with an unknown cause affecting multiple joints

HLA B27 Test (Human Leucocyte Antigen B27)/Packages that You Can Book With Metropolis Healthcare

Metropolis Healthcare offers comprehensive testing options related to HLA typing and autoimmune conditions:

HLA B27 Test (Human Leucocyte Antigen B27) Prices in Different Cities

The HLA B27 test (Human Leucocyte Antigen B27) prices may vary depending on your location. Here's a table showing the approximate prices in different cities: