Immunofixation Quantitative (Ife) Test
Also known as: Immunofixation Quantitative Serum Test
Immunofixation Quantitative Serum Test Details in Brief
| Also Known As | Immunofixation Electrophoresis (IFE), Serum Immunofixation, Protein Electrophoresis with Immunofixation, Monoclonal Gammopathy Evaluation |
|---|---|
| Purpose | Measures specific immunoglobulin levels, helps in diagnosing monoclonal gammopathies, supports differentiation of B-cell malignancies, useful in disease monitoring and prognosis |
| Preparation | Clinical history required |
| Fasting | No fasting required |
| Reporting Time | Same Day: 9:00 PM (depending on the test schedule days) |
| Cost | 8,810 |
What is an Immunofixation Quantitative Test?
An immunofixation quantitative serum test is a specialised blood test that identifies and measures abnormal proteins in your blood. The test helps detect and characterise specific types of abnormal proteins called monoclonal proteins (or M-proteins), which can indicate certain blood cancers like multiple myeloma or other related conditions.
What Does the Immunofixation Quantitative Test Measure?
This comprehensive test measures several important aspects of your blood proteins:
- Separates proteins in your blood serum based on their size and electrical charge
- Identifies specific types of immunoglobulins (antibodies) including IgG, IgA, and IgM
- Detects abnormal monoclonal proteins (M-proteins) that may indicate disease
- Measures the exact amount and concentration of any abnormal proteins found
- Evaluates light chains (kappa and lambda) that are part of antibody structure
- Assesses beta-2-microglobulin levels, which can indicate certain conditions
Immunofixation Quantitative Serum Test: Who Needs It and Why It's Done
What Symptoms May Call for an Immunofixation Quantitative Serum Test?
Your doctor may recommend this test if you experience symptoms that suggest plasma cell disorders:
- Persistent bone pain, especially in the back, hips, or ribs
- Unexplained weakness and extreme fatigue
- Frequent infections and recurring fevers
- Unexplained weight loss
- Kidney problems identified through other tests
- Nerve problems like numbness, weakness, or tingling sensations
Who should get an Immunofixation Quantitative Serum Test?
This specialised test is typically recommended for specific groups of people:
- Patients experiencing the symptoms mentioned above
- Individuals with abnormal results on routine protein screening tests
- People with suspicious findings on Serum Protein Electrophoresis (SPEP)
- Patients already diagnosed with multiple myeloma or related disorders for monitoring
- Those with a family history of blood cancers requiring evaluation
Why is an Immunofixation Quantitative Serum Test done?
This test is performed to confirm the presence of specific abnormal proteins (M-proteins), identify their exact type, and measure their quantity, which is essential for accurately diagnosing and managing serious conditions like multiple myeloma and other plasma cell disorders.
Importance of an Immunofixation Quantitative Serum Test
The immunofixation quantitative test plays a crucial role in modern healthcare by providing precise diagnostic information. This test offers exceptional accuracy in identifying specific abnormal proteins that other tests might miss, making it essential for distinguishing between different types of plasma cell disorders.
For patients undergoing treatment, this test serves as a vital monitoring tool, helping doctors track treatment effectiveness by measuring changes in M-protein levels. The comprehensive nature of this test also helps in determining disease prognosis and guides treatment decisions, making it an invaluable tool in managing complex blood-related health conditions.
Immunofixation Quantitative Serum Test Booking & Reports – Metropolis Healthcare India
How to Book an Immunofixation Quantitative Serum Test?
- Simple Online Booking
Booking can be done through the Metropolis Healthcare App or website. Select the Immunofixation Quantitative Serum test, choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab. - Safe Home Sample Collection
Our trained phlebotomists ensure the timely collection of your sample while strictly following all safety and hygiene protocols. - Sample Tracking Updates
Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. - Accurate Laboratory Testing
Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. - Quick & Easy Reports
Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app.
Is home sample collection for Immunofixation Quantitative Serum Test available near you?
Yes, Metropolis Healthcare provides home blood sample collection for the Immunofixation Quantitative Serum Test. Our trained phlebotomists visit your location at your preferred time, ensuring safe and hygienic sample collection following strict protocols. This service eliminates the need for hospital visits, making it easier for you to get tested in the comfort of your home.
How Long Does It Take to Get an Immunofixation Quantitative Serum Test Report?
Reports are usually available the same day by 9:00 PM, depending on when the sample reaches the lab and the test schedule days.
Where can I see or get Immunofixation Quantitative Serum Test results?
Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab.
Interpreting Immunofixation Quantitative Serum Test Results
What Your Immunofixation Quantitative Serum Test Results May Indicate
The following table provides guidance on understanding your test parameters and their reference ranges:
|
Parameters |
Reference Range |
High Values May Indicate |
Low Values May Indicate |
|
Total Protein |
6.4-8.3 gm/dL |
Dehydration, chronic infections, liver disease |
Malnutrition, kidney disease, liver problems |
|
Serum Albumin |
3.57-5.42 gm/dL |
Dehydration |
Liver disease, kidney problems, malnutrition |
|
IgG Total antibody, Serum |
700-1600 mg/dL |
Chronic infections, autoimmune disorders, liver disease |
Immunodeficiency disorders, protein-losing conditions |
|
IgA Total antibody, Serum |
70-400 mg/dL |
Chronic liver disease, autoimmune disorders, infections |
Immunodeficiency, protein-losing conditions |
|
IgM Total antibody, Serum |
40-230 mg/dL |
Acute infections, autoimmune diseases, liver disease |
Immunodeficiency, advanced malignancies |
|
Kappa Light Chains - Free, Serum |
3.3-19.4 mg/L |
Monoclonal gammopathy, multiple myeloma |
Immunodeficiency |
|
Lambda Light Chains - Free, Serum |
5.71-26.3 mg/L |
Monoclonal gammopathy, plasma cell disorders |
Immunodeficiency |
|
Beta-2 Microglobulin, Serum |
670-2143 ng/mL |
Multiple myeloma, lymphomas, kidney problems |
Usually not clinically significant |
Conditions that May Affect Immunofixation Quantitative Serum Test Accuracy
Several factors can influence your test results and should be discussed with your healthcare provider:
- Dehydration can concentrate blood proteins, potentially leading to falsely elevated levels.
- Certain medications, including immunosuppressive drugs and steroids, may affect protein production.
- Recent infections or inflammatory conditions can temporarily alter immunoglobulin levels.
- Kidney disease may affect the clearance of proteins from blood.
- Liver disease can impact protein synthesis and processing.
- Recent blood transfusions or intravenous immunoglobulin therapy may interfere with results.
- Extreme physical stress or recent surgery can temporarily affect protein levels.
How is an Immunofixation Quantitative Serum Test Done?
The test involves a straightforward blood collection process followed by sophisticated laboratory analysis:
- A healthcare professional cleans the area on your arm with an antiseptic.
- An elastic band is tied around your upper arm to make the veins more visible.
- A small needle is inserted into a vein to collect approximately 5ml of blood.
- The blood sample is placed in a special gel vacutainer tube.
- The needle is removed and a bandage is applied to the puncture site.
- Your sample is transported to the laboratory for analysis.
How Should You Prepare for an Immunofixation Quantitative Serum Test?
Preparing for this test is quite simple and requires minimal effort:
- No fasting required - You can eat and drink normally before the test
- Continue regular medications unless specifically advised otherwise by your doctor
- Stay well-hydrated by drinking adequate water before your test
- Inform your doctor about all medications, supplements, and herbal remedies you're taking
- Provide complete clinical history as this information helps in accurate interpretation
- Wear comfortable clothing with sleeves that can be easily rolled up for blood collection
Diseases that an Immunofixation Quantitative Serum Test Can Help Detect
This comprehensive test can help diagnose and monitor several serious health conditions:
- Multiple myeloma and other plasma cell disorders
- Waldenström's macroglobulinaemia
- AL amyloidosis and light chain deposition disease
- Monoclonal gammopathy of undetermined significance (MGUS)
- B-cell lymphomas and chronic lymphocytic leukaemia
- Primary immunodeficiency disorders
- Autoimmune conditions like systemic lupus erythematosus
- Chronic liver diseases affecting protein production
Immunofixation Quantitative Serum Test/Packages that You Can Book With Metropolis Healthcare
The following related tests and packages complement the Immunofixation Quantitative Serum Test for comprehensive evaluation:
|
Test/Package Name |
Purpose/Highlights |
|
Genetic markers for prognostication of multiple myeloma |
|
|
Measures specific antibody levels for immune system evaluation |
|
|
Initial screening test for protein abnormalities |
Immunofixation Quantitative Serum Test Prices in Different Cities
The cost of an Immunofixation Quantitative Serum Test may vary depending on your location. Here's a table showing the approximate prices in different cities:
|
City |
Price |
|
₹7000 to ₹9000 |
|
|
₹7000 to ₹9000 |
|
|
₹7000 to ₹9000 |
|
|
₹7000 to ₹9000 |
|
|
₹7000 to ₹9000 |
|
|
₹7000 to ₹9000 |
Reference:
Khan SR, van der Burgh AC, et al. Determinants of Serum Immunoglobulin Levels: A Systematic Review and Meta-Analysis. Front Immunol. 2021 Apr 7;12:664526. doi:10.3389/fimmu.2021.664526. PMID: 33897714; PMCID:PMC8058410
Immunofixation Quantitative Serum Test Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Immunofixation Quantitative Serum Test with a clear pricing structure.
The Immunofixation Quantitative Serum Test Price in Pune is ₹ 8,810 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
There is no specific best time of day for this test. You can schedule your blood collection at any convenient time since the test doesn't require fasting or special timing considerations.
No, overnight fasting is not required for this test. You can eat and drink normally before your appointment. However, if other tests are being done simultaneously, fasting requirements may differ.
Yes, dehydration can concentrate blood proteins and potentially lead to falsely elevated results. It's recommended to stay well-hydrated before your test for the most accurate measurements and easier blood collection.
No special dietary preparation is needed. However, inform your doctor about all medications, supplements, and herbal remedies you're taking, as some may potentially interfere with test results or interpretation.
A healthcare professional cleans your arm, applies a tourniquet, inserts a needle into a vein, collects blood in a vial, and applies a bandage. The process takes just a few minutes.
Risks are minimal and similar to any routine blood draw. You may experience slight pain, minor bruising at the needle site, or rarely, dizziness. Serious complications like infection are extremely rare.
Normal results show "No monoclonal protein detected" in the immunofixation analysis. All immunoglobulin levels, light chains, and other protein components should fall within their respective reference ranges as provided in your report.
This test is also known as Immunofixation Electrophoresis (IFE), Serum Immunofixation, Protein Electrophoresis with Immunofixation, and Monoclonal Gammopathy Evaluation.
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