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Accurate and Safer Diagnosis with Metropolis PregascreenTM Reflex Testing with NIPT: A Metropolis Study



In the realm of prenatal care, ensuring the health and well-being of both mother and child is paramount. The early detection of chromosomal anomalies in fetuses plays a crucial role in providing families with accurate information and facilitating informed decision-making. The advancement of medical technology has led to the development of innovative screening approaches, offering more accurate results and reducing the need for invasive procedures. One such groundbreaking method is the Metropolis PregascreenTM reflex testing with Non-Invasive Prenatal Testing (NIPT), which promises accurate and safer diagnosis.

Understanding Prenatal Screening

Prenatal screening has undergone significant evolution over the years, moving from basic ultrasound assessments to sophisticated genetic testing methods. Traditional approaches, such as maternal biochemical dual and quadruple markers, have been widely used to assess the risk of fetal chromosomal abnormalities. However, these methods have limitations in terms of their detection rates and potential for false positives.

Enter Metropolis PregascreenTM Reflex Testing

The Metropolis PregascreenTM reflex testing approach introduces a paradigm shift in prenatal screening. This innovative strategy combines traditional maternal biochemical markers with cutting-edge technology to provide more accurate and comprehensive results. The crux of this approach lies in the incorporation of NIPT, a method that evaluates cell-free fetal DNA (cfDNA) from maternal blood to detect common chromosomal abnormalities.

The Metropolis Study

To assess the clinical validity of the Metropolis PregascreenTM reflex testing approach, a comprehensive study was conducted. The study involved analyzing retrospective data from 51,574 Indian women who underwent maternal marker screening between January 2021 and March 2022. The goal was to determine the effectiveness of this approach in accurately identifying high-risk cases and providing a safer diagnostic path.

The study yielded promising results, showcasing the potential of the Metropolis PregascreenTM reflex testing approach. Out of the total high-risk cases identified through traditional screening methods, a significant portion—34.65%—opted for NIPT. This choice reflects the growing trust in the accuracy and reliability of NIPT in identifying chromosomal anomalies. Furthermore, the study demonstrated that NIPT had the ability to reclassify a substantial percentage of high-risk cases as low risk, leading to a more accurate assessment and potentially reducing unnecessary stress for expectant parents.

Advantages of Metropolis PregascreenTM Reflex Testing

The Metropolis PregascreenTM reflex testing approach offers several advantages that contribute to accurate and safer diagnosis:

  1. Reduced Need for Invasive Procedures: One of the most significant benefits is the reduced reliance on invasive procedures like chorionic villus sampling and amniocentesis. NIPT provides a non-invasive option that yields accurate results without the associated risks of miscarriage.
  2. High Accuracy: The study showcased that the accuracy of NIPT, when integrated with the Metropolis PregascreenTM reflex testing approach, is comparable to karyotyping, the gold standard for chromosomal anomaly detection.
  3. Informed Decision-Making: Accurate and early diagnosis empowers expectant parents with the information they need to make informed decisions regarding their pregnancy.
  4. Safer Diagnostic Journey: By minimizing the need for invasive procedures, the approach reduces potential risks to both the mother and the fetus, leading to a safer diagnostic journey.


The Metropolis PregascreenTM reflex testing approach with NIPT heralds a new era in prenatal care. Its ability to accurately identify high-risk cases and provide a safer diagnostic path signifies a positive transformation in the way we approach prenatal screening. The study's findings underscore the significance of integrating advanced technology with traditional screening methods to achieve more accurate results, greater patient satisfaction, and ultimately, healthier outcomes for both mothers and their unborn children. As we continue to embrace the potential of innovative approaches, we move closer to a future where accurate and safer diagnoses become the norm in prenatal care.

Read the Original Article here - Clinical utility of PregascreenTM reflex genetic testing for pre-natal screening in Indian population: A new diagnostic approach - IJOGR

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