Home Visit
Upload
PLA2 Receptor Antibody Quantitative Test
Also known as: PLA2 RECEPTOR ANTIBODY QUANTITATIVE , SERUM
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
NABL & CAP Accredited Labs
Accurate & Quality Test Reports
Trusted by Leading Doctors & Hospitals
PLA2 RECEPTOR ANTIBODY QUANTITATIVE , SERUM Details in Brief
| Also Known As | PLA2R Antibody Test, Phospholipase A2 Receptor Antibody Test |
|---|---|
| Purpose | To diagnose and monitor primary membranous nephropathy (PMN), a kidney disease caused by autoimmune antibodies |
| Preparation | No special preparation required |
| Fasting | Fasting not required |
| Reporting Time | Same day |
| Cost | 5,800 |
What is a PLA2 Receptor Antibody Quantitative Test?
The PLA2 Receptor Antibody Quantitative Test is a blood test that measures antibodies against the phospholipase A2 receptor (PLA2R) protein. These antibodies are commonly present in primary membranous nephropathy (PMN), an autoimmune kidney disease in which the immune system targets podocytes (cells that form the kidney’s filtration barrier), leading to leakage of protein into the urine (proteinuria).
This test supports diagnosis, monitoring of disease activity, assessment of response to therapy, and relapse/recurrence risk evaluation, often reducing the need for repeat kidney biopsies. The test is performed on a serum (blood) sample.
What Does a PLA2 Receptor Antibody Quantitative Test Measure?
The test provides clinically useful information by measuring:
- PLA2R Antibody Levels: Detects and quantifies antibodies directed against PLA2R.
- Disease Activity: Higher titres generally correlate with active autoimmune disease.
- Treatment Response: Falling titres typically indicate improving immunologic activity and response to therapy.
- Prognostic Value: Persistently high titres may indicate higher risk of progression or relapse, including post-transplant recurrence risk.
- Diagnostic Support: Helps distinguish primary membranous nephropathy from many secondary causes when interpreted with clinical context.
PLA2 Receptor Antibody Quantitative Test: Who Needs It and Why It’s Done
What Symptoms May Call for a PLA2 Receptor Antibody Quantitative Test?
Your doctor may recommend this test if you have symptoms suggestive of kidney disease, such as:
- Swelling in the legs, ankles, or around the eyes
- Foamy urine due to protein loss
- Fatigue or reduced urine output
- High blood pressure
- Abnormal kidney function or proteinuria on routine urine/blood testing
Who Should Get a PLA2 Receptor Antibody Quantitative Test?
This test is particularly useful for:
- Patients suspected of having primary membranous nephropathy (PMN)
- Individuals with unexplained proteinuria (protein in urine)
- Patients on treatment for PMN to monitor therapy effectiveness
- Kidney transplant recipients to assess risk of recurrence
- Individuals with biopsy features suggestive of membranous nephropathy
Why is a PLA2 Receptor Antibody Quantitative Test Done?
The test detects and quantifies antibodies implicated in PMN, supporting diagnosis, treatment planning, prognostic assessment, and ongoing monitoring of immunologic disease activity.
Importance of a PLA2 Receptor Antibody Quantitative Test
Anti-PLA2R is a key non-invasive biomarker in PMN that helps clinicians determine whether disease is immunologically active, evaluate treatment response, and anticipate relapse. When combined with clinical findings (proteinuria, serum albumin, creatinine, urinalysis), it supports risk stratification and more personalised management.
PLA2 Receptor Antibody Quantitative Test Booking & Reports – Metropolis Healthcare
How to Book the PLA2 Receptor Antibody Quantitative Test and Get Your Reports?
- Simple Online Booking
Book through the Metropolis Healthcare app or website. Select the test, choose a slot, and opt for home collection or visit the nearest Metropolis Lab. - Safe Sample Collection
A trained phlebotomist collects the blood sample using sterile technique. - Sample Tracking Updates
Track sample status through the Metropolis platform. - Accurate Laboratory Testing
Testing is performed at NABL & CAP accredited laboratories using immunoassay methodology (EIA/ELISA) for quantitative measurement. - Report Delivery
Reports are typically shared via email, WhatsApp, and/or downloadable through the Metropolis portal/app.
Is Home Sample Collection for PLA2 Receptor Antibody Quantitative Test Available Near You?
Yes. Home blood collection is generally available, subject to local service availability.
How Long Does It Take to Get a PLA2 Receptor Antibody Quantitative Test Report?
Reports are generally available the same day once the sample reaches the lab.
Note: Reporting time and cost may vary based on your location.
Where Can I See or Get PLA2 Receptor Antibody Quantitative Test Results?
Results can be accessed via the Metropolis website/app and may also be delivered through email or WhatsApp. Printed copies can be collected from the nearest lab, if required.
Interpreting PLA2 Receptor Antibody Quantitative Test Results
What Your PLA2 Receptor Antibody Quantitative Test Results May Indicate
|
Parameter |
Normal Range |
Interpretation |
|
PLA2R Antibody (Quantitative) |
Negative: <14 RU/mL |
Higher levels generally indicate active primary membranous nephropathy (PMN). Low/negative levels may suggest remission or absence of PLA2R-associated PMN. Interpretation must be correlated with clinical findings. |
Understanding Abnormal PLA2 Receptor Antibody Quantitative Test Results by Parameter
|
Parameter |
High Values May Indicate |
Low/Normal Values May Indicate |
|
PLA2R Antibody (Quantitative) |
Active or worsening PMN; potential risk of relapse or post-transplant recurrence |
Remission phase, good response to treatment, or absence of PLA2R-associated PMN |
How Should You Prepare for a PLA2 Receptor Antibody Quantitative Test?
- No fasting required; you can eat and drink normally.
- Medication disclosure: Inform your doctor/lab about immunosuppressants, steroids, or other ongoing therapies as they may influence antibody levels.
- Avoid scheduling during acute illness unless advised by your clinician.
- Stay well hydrated before the blood draw.
How Is a PLA2 Receptor Antibody Quantitative Test Done? (Step-by-Step Procedure)
- Preparation: Vein is selected and a tourniquet is applied.
- Skin cleansing: Site cleaned with antiseptic.
- Sample collection: Blood is drawn (commonly ~3 ml) into an appropriate vacutainer.
- Processing: Serum is separated and tested using an immunoassay (EIA/ELISA) method to quantify anti-PLA2R antibodies.
- Reporting: Results are released with reference ranges and clinical interpretation guidance.
Conditions That May Affect PLA2 Receptor Antibody Quantitative Test Accuracy
- Immunosuppressive treatment (may lower antibody titres)
- Acute infections or concurrent autoimmune conditions (may influence immune markers)
- Testing too soon after treatment changes (may not reflect steady-state antibody activity)
Diseases That a PLA2 Receptor Antibody Quantitative Test Can Help Detect
- Primary membranous nephropathy (PMN) associated with anti-PLA2R antibodies
- Recurrent membranous nephropathy after kidney transplant (risk assessment/monitoring)
- Autoimmune glomerular disease activity monitoring (as part of broader nephrology evaluation)
Note: The test is most specific for PLA2R-associated PMN; diagnosis and management should be based on full clinical correlation.
PLA2 receptor antibody Quantitative Test Samples Price in Different Cities
The cost of a PLA2 receptor antibody Quantitative Test Samples may vary depending on your location. Here's a table showing the approximate price range for the PLA2 receptor antibody Quantitative Test Samples at Metropolis Healthcare in major Indian cities:
|
City |
Approximate Cost (INR) |
|
₹ 5,400 to ₹ 5,800 |
|
|
₹ 5,400 to ₹ 5,800 |
|
|
₹ 5,400 to ₹ 5,800 |
|
|
₹ 5,400 to ₹ 5,800 |
The PLA2 receptor antibody Quantitative Test Samples cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive PLA2 receptor antibody Quantitative Test Samples prices across major cities in India.
References
- Beck L.H., Bonegio R.G., Lambeau G., et al. (2009). M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. New England Journal of Medicine, 361(1), 11–21. PMID: 19571279
- Hofstra J.M., Wetzels J.F.M. (2016). Anti-PLA2R antibodies in membranous nephropathy: What do they tell us? Clinical Journal of the American Society of Nephrology, 11(8), 1240–1243. PMID: 26966057
- Tomas N.M., Beck L.H., Meyer-Schwesinger C., et al. (2014). Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. New England Journal of Medicine, 371(24), 2277–2287. PMID: 25470796
- Ruggenenti P., Debiec H., Ruggiero B., et al. (2015). Anti-phospholipase A2 receptor antibody titer predicts posttransplant recurrence of membranous nephropathy. Journal of the American Society of Nephrology, 26(10), 2549–2558. PMID: 25644108
- KDIGO Glomerulonephritis Work Group. (2021). KDIGO Clinical Practice Guideline for Glomerular Diseases. Kidney International, 100(4S), S1–S276. PMID: 34633305
PLA2 RECEPTOR ANTIBODY QUANTITATIVE , SERUM Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the PLA2 RECEPTOR ANTIBODY QUANTITATIVE , SERUM with a clear pricing structure.
The PLA2 RECEPTOR ANTIBODY QUANTITATIVE , SERUM Price in Mumbai is ₹ 5,800 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
A high level suggests active primary membranous nephropathy (PMN) or higher risk of relapse/recurrence (including after kidney transplant), depending on clinical context.
It is primarily used for diagnosing and monitoring primary membranous nephropathy, and it may support broader autoimmune kidney evaluations when interpreted with other findings.
No. Fasting is not required.
Yes. Immunosuppressive medications and steroids may lower antibody levels. Always inform your doctor about current treatments.
A blood sample is collected and the antibody level is measured using an immunoassay (EIA/ELISA) method.
A negative result may indicate no active PLA2R-associated PMN or remission; however, membranous nephropathy can be PLA2R-negative, so clinical correlation is essential.
Frequency depends on your clinical situation; your doctor may repeat it periodically (often every few months) to monitor disease activity and treatment response.
Ratings & Reviews (0)
Why Metropolis?
Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
WhatsApp