Pheochromocytoma Marker Profile-II Test

This test measures the levels of plasma adrenaline, nor-adrenaline, metanephrine, nor-metanephrine, and VMA in urine.

• To diagnose pheochromocytoma • To monitor the effectiveness of treatment for pheochromocytoma • To assess the risk of developing pheochromocytoma in patients with a family history or a genetic predisposition to the disease.

Your doctor might recommend this test if you have • symptoms suggestive of pheochromocytoma, like high blood pressure, headaches, palpitations or sweating, • a previous diagnosis of pheochromocytoma, or • a family history or genetic risk factors for pheochromocytoma.

Elevated levels of the tested hormones may indicate the presence of pheochromocytoma or other conditions that affect adrenal gland function. However, abnormal results do not necessarily mean that you have cancer or any other serious condition.

• A sample of 4 ml of EDTA (Ethylenediaminetetraacetic acid) plasma and 20 ml of urine (24H) is collected. • The samples are then sent to a laboratory for testing.

• Follow any instructions provided by your doctor regarding medication use and inform them if you have any specific requirements. • Do not smoke or consume caffeine or alcohol before the test. • Avoid certain foods like chocolate, vanilla, bananas, avocados, and citrus fruits that contain tyramine for 48 hours before the test.

Plasma catecholamines: A blood test to measure adrenaline and noradrenaline levels

Adrenaline, Nor-Adrenaline, Metanephrine and Nor-Metanephrine, VMA Panel

Pheochromocytoma is a rare tumour that develops in the adrenal glands. This tumour can produce an excess of hormones like adrenaline and nor-adrenaline, leading to symptoms like high blood pressure, headaches, palpitations, and sweating.

Adrenaline is a hormone and neurotransmitter involved in the body's stress response. Elevated levels of adrenaline can be indicative of pheochromocytoma.

Noradrenaline is another hormone and neurotransmitter involved in the stress response. Elevated levels of noradrenaline can also suggest pheochromocytoma.

Metanephrine is a metabolite of adrenaline and noradrenaline. Elevated levels of metanephrine can be an indicator of pheochromocytoma.

Normetanephrine is a metabolite of adrenaline and noradrenaline similar to metanephrine. Elevated levels of normetanephrine can also suggest pheochromocytoma.

VMA is a metabolite of adrenaline and noradrenaline that is excreted in the urine. Increased VMA levels can be associated with pheochromocytoma.