NextGen Colocore Targeted Panel - MSI ( PCR)

What Is a Colocore Targeted Panel - MSI (PCR)? 

A NextGen Colocore Targeted Panel - MSI (PCR) is a specialised genetic test that examines your DNA for specific changes in cancer cells. The test uses Next-Generation Sequencing (NGS) technology to look at eight important genes and check for microsatellite instability (MSI) in tumour tissue. This test helps doctors understand the genetic makeup of your cancer and guides them in choosing the most effective treatment for your health conditions. 

What Does the Colocore Targeted Panel - MSI (PCR) Measure? 

The NextGen Colocore Targeted Panel measures several important aspects of cancer genetics to guide your treatment: 

• Gene mutations: Checks for changes in eight key cancer-related genes (TP53, KRAS, NRAS, BRAF, ERBB2, NTRK1/2/3, PIK3CA). 

• Microsatellite instability (MSI): Examines the DNA repair system function in cancer cells. 

• Treatment response markers: Identifies genetic features that predict how well certain therapies might work. 

• Targeted therapy options: Determines if you may benefit from specific cancer treatments. 

• Immunotherapy eligibility: Helps identify patients who may respond well to checkpoint inhibitor treatments. 

Colocore Targeted Panel - MSI (PCR): Who Needs It and Why It's Done 

What Symptoms May Call for a Colocore Targeted Panel - MSI (PCR)? 

The NextGen Colocore Targeted Panel is ordered after a cancer diagnosis has been made, typically when you have experienced symptoms that led to cancer detection: 

• Persistent changes in bowel habits, such as diarrhoea or constipation 

• Blood in stool or rectal bleeding 

• Persistent abdominal discomfort, cramps, or pain 

• Feeling that your bowel doesn't empty completely 

• Unexplained weight loss and fatigue 

• Persistent stomach pain or nausea 

Who Should Get a Colocore Targeted Panel - MSI (PCR)? 

Your doctor may recommend the NextGen Colocore Targeted Panel if you fall into these categories: 

• Patients with colorectal cancer: Especially those needing targeted treatment guidance. 

• Individuals with endometrial cancer: To determine treatment options 

• Patients with gastric cancer: For personalised therapy selection 

• People with lung cancer: Particularly for identifying targeted therapy opportunities 

• Patients with ovarian cancer: To guide treatment decisions 

• Individuals with a strong family cancer history: To check for inherited cancer syndromes 

Why Is a Colocore Targeted Panel - MSI (PCR) Done? 

This test provides crucial information that helps your doctor choose the most effective treatment plan for your specific type of cancer and identify if you have Lynch syndrome, an inherited condition that increases cancer risk. 

Importance of a Colocore Targeted Panel - MSI (PCR) 

The NextGen Colocore Targeted Panel - MSI (PCR) plays a vital role in modern cancer care by personalising your treatment approach. This test identifies specific genetic changes in your tumour that can predict which treatments will work best for you. 

For patients with MSI-high tumours, this test can unlock access to immunotherapy treatments that may be highly effective. It also helps detect Lynch syndrome, allowing family members to undergo genetic counselling and screening. The test results guide oncologists in selecting targeted therapies, potentially improving treatment outcomes while avoiding ineffective treatments. 

Colocore Targeted Panel - MSI (PCR) Booking & Reports – Metropolis Healthcare India 

How to Book a Colocore Targeted Panel - MSI (PCR)? 

1. Simple Online Booking 
   Booking can be done through the Metropolis Healthcare App or website. Select the 'NextGen Colocore Targeted Panel - MSI (PCR)', choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab. 
    
2. Safe Home Sample Collection 
   Our trained phlebotomists ensure the timely collection of your sample while strictly following all safety and hygiene protocols. 
    
3. Sample Tracking Updates 
   Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. 
    
4. Accurate Laboratory Testing 
   Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 
    
5. Quick & Easy Reports 
   Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is Home Sample Collection for the Colocore Targeted Panel - MSI (PCR) Available Near You? 

Yes, home blood sample collection is available for the NextGen Colocore Targeted Panel through Metropolis Healthcare. Our trained phlebotomists visit your home with proper safety protocols to collect blood samples and coordinate tissue sample requirements. With our extensive network of over 10,000 touchpoints across India, reliable home collection is available in most areas, making advanced cancer genetic testing accessible and comfortable for you. 

How Long Does It Take to Get a Colocore Targeted Panel - MSI (PCR) Report? 

Reports are usually available within 4 weeks once the sample reaches the pathology lab. 

Note: Reporting time may vary depending on your location. 

Where Can I See or Get Colocore Targeted Panel - MSI (PCR) Results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare App to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting Colocore Targeted Panel - MSI (PCR) Results 

What Your Colocore Targeted Panel - MSI (PCR) Results May Indicate 

The following table shows the key parameters analysed in the NextGen Colocore Targeted Panel and what the findings may indicate for your cancer treatment: 

Parameters	Finding	Clinical Significance
TP53	Mutation detected/Not detected	Guides treatment selection and prognosis assessment
KRAS	Mutation detected/Not detected	Predicts response to targeted therapies
NRAS	Mutation detected/Not detected	Influences treatment decisions
BRAF	Mutation detected/Not detected	Identifies eligibility for specific targeted drugs
ERBB2	Mutation detected/Not detected	Determines HER2-targeted therapy options
NTRK (1, 2, 3)	Fusion detected/Not detected	Identifies candidates for NTRK inhibitor therapy
PIK3CA	Mutation detected/Not detected	Guides PI3K pathway targeted treatment
MSI-PCR	MSI-High/MSI-Low/MSS	Predicts immunotherapy response and Lynch syndrome risk

Conditions that May Affect Colocore Targeted Panel - MSI (PCR) Accuracy 

Several factors can influence the accuracy of your genetic test results and should be discussed with your healthcare team: 

• Sample quality: Poor tissue preservation or insufficient tumour content may affect results. 

• Previous chemotherapy: Prior cancer treatments can alter DNA quality in tissue samples. 

• Sample age: Older tissue blocks may have degraded DNA, affecting test accuracy. 

• Contamination: Normal tissue mixed with tumour tissue can dilute genetic findings. 

• Technical factors: Laboratory processing conditions and storage temperature can impact results. 

• Tumour heterogeneity: Different areas of the same tumour may have varying genetic profiles. 

How Is a Colocore Targeted Panel - MSI (PCR) Done? 

The NextGen Colocore Targeted Panel process involves several carefully coordinated steps to ensure accurate genetic analysis: 

• Sample collection: A blood sample (3 ml EDTA) is drawn from your vein using standard venipuncture. 

• Tissue requirement: FFPE (formalin-fixed paraffin-embedded) tissue block from your biopsy or surgery is needed. 

• Laboratory processing: Samples are transported to the molecular pathology lab under proper temperature conditions. 

• DNA extraction: Genetic material is carefully extracted from both blood and tissue samples. 

• Next Generation Sequencing: Advanced NGS technology analyses the ten target genes and MSI status. 

• Quality control: Multiple checks ensure result accuracy before report generation. 

How Should You Prepare for a Colocore Targeted Panel - MSI (PCR)? 

Preparing for this genetic test is straightforward and requires minimal steps: 

• No fasting required: You can eat and drink normally before the blood collection. 

• Continue medications: Take your regular medicines unless your doctor advises otherwise. 

• Gather medical records: Ensure your clinical history, histopathology, and IHC reports are available. 

• Tissue block coordination: Confirm your FFPE tissue block is available from a previous biopsy or surgery. 

• Comfortable clothing: Wear clothes that allow easy access to your arm for a blood draw. 

Diseases that a Colocore Targeted Panel - MSI (PCR) Can Help Detect 

This comprehensive genetic test aids in the diagnosis and management of several cancer types: 

• Colorectal cancer: Primary indication for MSI testing and targeted gene analysis 

• Endometrial cancer: Helps identify Lynch syndrome pane and treatment options 

• Gastric cancer: Guides targeted therapy selection and immunotherapy eligibility 

• Ovarian cancer: Determines personalised treatment approaches 

• Lynch syndrome: Inherited cancer predisposition syndrome affecting multiple organs 

• Lung cancer: Identifies targetable mutations for precision therapy 

• Breast cancer: Helps guide treatment decisions in specific cases 

• Thyroid cancer: Assists in determining treatment strategies 

Colocore Targeted Panel - MSI (PCR)/Packages that You Can Book With Metropolis Healthcare 

Several cancer-related diagnostic tests and comprehensive packages are available at Metropolis Healthcare to support your healthcare needs: 

Test/Package Name	Purpose/Highlights
Colectomy Histopathology, KRAS mutations, Special stains & Reflex IHC Test	Detailed tissue examination after colon surgery
Tumour Marker Panel (270 Genes) Comprehensive, FFPE	Extensive genetic profiling for personalised cancer treatment
Tumour Mutation Burden NGS	Measures total genetic changes to predict immunotherapy response