MPN Comprehensive Panel (Bone Marrow) Test

This test measures:

• Bcr-Abl (PHILADELPHIA) t(9 22) by FISH
• Calreticulin (CALR) Exon 9 Mutation Analysis
• JAK-2 Mutation (CMPD) (V617F)
• JAK-2 Mutation (CMPD) Exon 12 Mutation
• MPL W515/S505 Mutation Analysis

These measurements help identify genetic abnormalities linked to MPNs, providing crucial insights into your blood cell production and potential risks

• To diagnose myeloproliferative neoplasms
• To monitor the progression of MPNs
• To guide treatment decisions for MPNs
• To assess response to therapy
• To determine the risk of disease recurrence
• To evaluate the effectiveness of therapeutic interventions

The MPN Comprehensive Panel (Bone Marrow) Test is recommended:

• If you experience symptoms like unexplained fatigue, night sweats, or abdominal discomfort
• If you have a family history of blood disorders
• Patients with diagnosed MPNs or undergoing treatment for these conditions may also require this test to monitor their health

Abnormal result indicates:

• Presence of myeloproliferative neoplasm
• Increased risk of blood clotting
• Altered blood cell production

Discuss any abnormal results with your doctor for further evaluation and appropriate management

• Sample collection involves bone marrow aspiration
• Local anesthesia is used for comfort
• Mild discomfort or pressure may be felt during the procedure
• The samples are sent to a lab for analysis

• Follow your doctor’s advice on fasting before the procedure
• Inform about any medications you are currently taking
• Stay hydrated but avoid heavy meals before testing
• Arrive at the clinic with a responsible adult if sedation is required
• Follow specific instructions given by your doctor

• Bcr-Abl Testing: Detects the Philadelphia chromosome in chronic myeloid leukemia
• CALR Gene Mutation Testing: Identifies mutations associated with myeloproliferative disorders
• JAK2 Mutation Testing: Checks for mutations contributing to various blood disorders

MPN Screening Panel (Bone Marrow)

MPNs are a group of rare blood cancer where the bone marrow produces excess blood cells. This condition can cause irregular blood cell counts, clotting issues, and a higher risk of other health complications. Regular monitoring and appropriate treatment are essential for managing MPNs effectively