Metanephrine Level Test - HPLC, 24 hrs Urine

Also known as: Metanephrine Level, Urine 24 Hrs

50+ booked in last 3 days

Sample Type

Urine

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Male, Female

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Metanephrine Level, Urine 24 Hrs Details in Brief

Also Known As	24-Hour Urinary Metanephrines Test, Metanephrine Urine Test
Purpose	To measure metanephrine levels in 24-hour urine and help diagnose adrenal gland tumours such as pheochromocytoma and paraganglioma
Preparation	Avoid caffeine, alcohol, chocolate, bananas, citrus fruits, and certain medicines before and during urine collection as advised by your doctor
Fasting	Fasting not required
Reporting Time	After 3 days
Cost	3,500

What Is a Metanephrine Level Test?

The Metanephrine Level Test measures the amount of metanephrines in your urine collected over 24 hours. Metanephrines are substances formed when your body breaks down adrenaline and noradrenaline, hormones that regulate stress and blood pressure.

This test helps your doctor detect rare tumours of the adrenal glands known as pheochromocytomas and paragangliomas. These tumours can produce excess hormones, leading to symptoms such as high blood pressure, rapid heartbeat, headaches, and excessive sweating.

The test is performed on a 24-hour urine sample collected in a special container with acid preservative.

What Does a Metanephrine Level Test Measure?

The test measures total metanephrines excreted in your urine over a 24-hour period. It helps your doctor understand how much adrenaline and noradrenaline your body is breaking down.

The Metanephrine Level Test provides important clinical insights into:

Detecting adrenal tumours such as pheochromocytoma and paraganglioma
Evaluating causes of unexplained or resistant high blood pressure
Monitoring patients with known adrenal gland disorders
Assessing the success of tumour removal or response to treatment

Metanephrine Level Test: Who Needs It and Why It’s Done

What Symptoms May Call for a Metanephrine Level Test?

Your doctor may recommend this test if you experience symptoms suggesting excess catecholamines such as:

Persistent or unexplained high blood pressure
Episodes of severe headaches and pounding heartbeats
Profuse sweating or anxiety without clear cause
Rapid heartbeat (palpitations)
Tremors, pale skin, or sudden feelings of panic

Who Should Get a Metanephrine Level Test?

People with high blood pressure that doesn’t respond to regular treatment
Individuals with symptoms of catecholamine excess
Patients with adrenal or retroperitoneal masses seen on imaging
Those with a family history of pheochromocytoma or paraganglioma
Individuals undergoing follow-up after tumour removal

Why Is a Metanephrine Level Test Done?

The test helps confirm or rule out catecholamine-secreting tumours, guiding further imaging such as CT or MRI to locate the source.

Importance of a Metanephrine Level Test

Understanding your metanephrine levels helps detect rare but serious hormone-secreting tumours early, before complications arise. It aids doctors in tailoring treatment for high blood pressure, evaluating adrenal health, and monitoring post-surgical outcomes.

The 24-hour urine method provides a complete picture of hormone secretion patterns over a day.

Metanephrine Level Test Booking & Reports – Metropolis Healthcare

How to Book the Metanephrine Level Test and Get Your Reports

Booking:
Visit the Metropolis Healthcare website or App to book your Metanephrine Level Test. You can also contact your nearest Metropolis Lab for assistance.
Sample Collection:
Home sample collection is not available for this test. Please visit your nearest Metropolis Lab to collect the 24-hour urine container and receive instructions for accurate collection.
Sample Tracking:
Once submitted, you can track your test status and updates on the Metropolis Healthcare website.
Accurate Testing:
Your sample will be analysed using Liquid Chromatography–Mass Spectrometry (LC-MS/MS), ensuring high precision and reliability.
Quick Access to Reports:
Your test reports will be available within 3 days via email, WhatsApp, or for download on the Metropolis Healthcare website or App.

Is Home Sample Collection for Metanephrine Level Test Available Near You?

Home sample collection is not available for this test as it requires accurate 24-hour urine collection in a preservative container under controlled conditions. Visiting a Metropolis Lab ensures proper guidance, labelling, and sample preservation for reliable results.

How Long Does It Take to Get a Metanephrine Level Test Report?

Reports are usually available after 3 days once the sample reaches the lab.
Note: Reporting time may vary based on your location.

Where Can I See or Get Metanephrine Level Test Results?

You can access your results easily through the Metropolis Healthcare website or App using your login credentials. Reports are also sent via email or WhatsApp, or you may collect a physical copy from the Metropolis Lab.

Interpreting Metanephrine Level Test Results

What Your Metanephrine Level Test Results May Indicate

Parameter	Normal Range	High Values May Indicate	Low Values May Indicate
Metanephrine in urine (24 hrs)	74.0 – 297.0 μg/24 hrs	Pheochromocytoma, paraganglioma, stress, hypertension, illness, or kidney impairment	Usually not clinically significant

Understanding Abnormal Metanephrine Level Test Results by Parameter

Parameter	Possible Causes of High Results	Clinical Significance
Metanephrine in urine	Adrenal or extra-adrenal tumours (pheochromocytoma, paraganglioma), stress, intense exercise, antidepressants, caffeine intake	Indicates excessive catecholamine breakdown, often due to hormone-secreting tumours
Urine volume in 24 hrs	Low or high due to fluid intake, dehydration, or renal function	Affects concentration of measured analytes

How Should You Prepare for a Metanephrine Level Test?

Proper preparation helps ensure accurate results. Follow these steps carefully:

Avoid certain foods: Do not consume caffeine, alcohol, bananas, chocolate, vanilla, or citrus fruits for at least 48 hours before and during collection.
Medication review: Inform your doctor about all medicines, especially antidepressants, amphetamines, beta-blockers, and levodopa. Do not stop medications without medical advice.
Stress management: Try to remain calm and avoid strenuous exercise before and during urine collection.
Collection procedure: Exclude the first morning urine and include the last urine voided at the 24-hour mark.
Preservative use: Use the provided container with acid preservative (HCL) for the 24-hour collection as instructed.
Proper storage: Keep the collected urine refrigerated during the 24 hours and until it is delivered to the lab.

Conditions That May Affect Metanephrine Level Test Accuracy

Certain factors may interfere with your test results:

Consumption of caffeine, bananas, chocolate, citrus fruits, or vanilla before or during collection
Use of certain medicines such as antidepressants, amphetamines, beta-blockers, and levodopa
High physical or emotional stress during collection
Acute illness, infections, or kidney problems that affect hormone excretion
Failure to collect all urine samples within the 24-hour period

Diseases That a Metanephrine Level Test Can Help Detect

Pheochromocytoma (adrenal gland tumour)
Paraganglioma (neuroendocrine tumour outside the adrenal glands)
Secondary hypertension due to excess catecholamines
Adrenal gland hyperplasia
Hormone-secreting neuroendocrine tumours

Metanephrine Level Test Price in Different Cities

The cost of a Metanephrine Level Test may vary depending on your location. Here's a table showing the approximate price range for the Metanephrine Level Test at Metropolis Healthcare in major Indian cities:

City	Approximate Cost (INR)
Mumbai	₹ 3,500 to ₹ 4,300
Delhi	₹ 3,500 to ₹ 4,300
Bengaluru	₹ 3,500 to ₹ 4,300
Chennai	₹ 3,500 to ₹ 4,300

The Metanephrine Level Test cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive Metanephrine Level Test prices across major cities in India.

References

Eisenhofer G., Peitzsch M. (2014). Laboratory evaluation of pheochromocytoma and paraganglioma. Clin Chem, 60(12), 1486–1499. PMID: 25288150
Lenders J.W.M., Duh Q.Y., Eisenhofer G., Gimenez-Roqueplo A.P., Grebe S.K., Murad M.H., et al. (2014). Pheochromocytoma and paraganglioma: An endocrine society clinical practice guideline. J Clin Endocrinol Metab, 99(6), 1915–1942. PMID: 24893135
Peitzsch M., Prejbisz A., Kroiss M., et al. (2013). Analysis of plasma and urinary metanephrines for detection of pheochromocytoma and paraganglioma. Endocr Relat Cancer, 20(3), 405–416. PMID: 23509243
Eisenhofer G., Lenders J.W.M., Timmers H.J., et al. (2018). Biochemical diagnosis of pheochromocytoma and paraganglioma. Nat Rev Endocrinol, 14(5), 233–247. PMID: 29599454
Yu R., Wei M. (2019). Diagnostic evaluation and management of pheochromocytoma and paraganglioma. Endocrine Practice, 25(3), 305–312. PMID: 30632449

Metanephrine Level, Urine 24 Hrs Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Metanephrine Level, Urine 24 Hrs with a clear pricing structure.

The Metanephrine Level, Urine 24 Hrs Price in Trombay is ₹ 3,500 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

What does the Metanephrine Level Test detect?

It detects abnormal production of stress hormones that may indicate adrenal or extra-adrenal tumours such as pheochromocytoma or paraganglioma.

Why is a 24-hour urine sample required for this test?

Metanephrines are excreted throughout the day, so a 24-hour collection provides a more accurate assessment than a single sample.

Can stress affect Metanephrine test results?

Yes, high stress can temporarily increase metanephrine levels, so it is best to stay calm during the collection period.

Can I take my regular medicines before the test?

Inform your doctor about all medicines before the test. Some, such as antidepressants and beta-blockers, may interfere and need to be adjusted.

What foods should I avoid before the Metanephrine Level Test?

Avoid caffeine, bananas, chocolate, citrus fruits, and vanilla for at least two days before and during urine collection.

Is fasting required before the Metanephrine Level Test?

Fasting is not required, but dietary restrictions should be followed as advised by your doctor.

How should I store my urine sample during collection?

Keep the container refrigerated during the 24-hour collection period to maintain sample stability.

How are high metanephrine levels interpreted?

Persistently high levels suggest possible adrenal or neuroendocrine tumours and may prompt imaging tests like CT or MRI for confirmation.

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