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Leukemia Comprehensive Workup Panel Test-Acute Leukemia, Bone Marrow
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Sample Type
Blood
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Male, Female
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Overview
Leukemia also known as blood cancer occurs due to abnormal growth and mutations of the white blood cells. This mutation majorly occurs in the bone marrow, but may be seen in the peripheral blood as well. Acute leukaemia leads to the production of blasts or immature WBCs that can interfere with the normal blood cells like RBCs and platelets . Acute Leukemia is mainly classified into two types -Acute Myeloid Leukemia (AML) and Acute Lymphoid Leukemia (ALL). The Leukemia Comprehensive workup panel -Acute Leukemia, Bone marrow comprises of series of tests that include morphological examination of the peripheral blood cells followed by genotyping of leukemic cells for further diagnosis or classification. This helps in the diagnosis and further classification of Acute leukaemia into the specific type (AML or ALL).
- Dr.Shibani RMedical WriterMedical Affairs
Leukemia Comprehensive Workup Panel Test-Acute Leukemia, Bone Marrow Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Leukemia Comprehensive Workup Panel Test-Acute Leukemia, Bone Marrow with a clear pricing structure.
The Leukemia Comprehensive Workup Panel Test-Acute Leukemia, Bone Marrow Price in Mumbai is ₹ 26,500 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
The Leukemia Comprehensive workup panel -Acute Leukemia, Bone Marrow consists of morphological examination of heparin bone marrow sample followed by cytogenetic analysis to detect translocations and genetic mutations in AML and ALL cases using FISH.
Leukemia may often be asymptomatic in the early stages. People with following clinical signs should however, undergo the test:
- Fatigue, easy tiredness
- Unexplained weight loss
- Frequent infections, fever
- Bone or joint pain and tenderness
- Easy bleeding or bruising with red spots or purplish discoloration.
- In case of abnormalities detected in the routine blood examination (CBC) along with other investigations, the Leukemia comprehensive panel may be useful for further diagnosis.
- The test is done in patients in whom acute leukaemia or lymphoma is suspected.
- To find out the type of Acute leukaemia (AML or ALL) based on the blood studies.
- This panel aids proper diagnosis, helps in choosing the right treatment line and monitoring of the patient.
This test requires bone marrow sample along with whole blood smear. A small incision is made on the skin, and a hollow needle is inserted from the bone up to the bone marrow to collect the bone marrow sample. The skin is disinfected before needle insertion and the sample is collected in vacutainer.
Medical history / Heamato-pathological reports is required.
The immunophenotyping of leukemic cells in bone marrow shows differential count of various blood cells.
Based on the differential count percentage, diagnosis of leukemia and its type can be made.
The positivity percentage of Lymphoid T cells, Lymphoid B cells, Myeloid cells and Monocytic cells is further indicative of the Leukemia diagnosis and its respective classification.eg. B - Cell Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia.
Leukemia Translocation Panel (AML)
Positive result may show translocation in INV 16 (P13;Q22), T(15;17) (Q21;Q22), T(8;21) (Q22;Q22) genes. Depending on the translocation type, the prognosis can be determined.
Leukemia panel by FISH - ALL, Leukemic Blood
Positive or abnormal results show rearrangements or mutations in E2A , TEL/AML1 ES, BCR/ABL or MLL genes.
Further correlation with clinical findings, bone marrow studies and cytogenetics studies should also be done.
Based on the results, the prognosis can be determined.
Morphological examination of bone marrow for abnormalities (Differential count, blasts, neutrophils, lymphocytes, eosinophils percentage), RBC structure and platelets examination is done.
The leukaemia cells may continue to multiply and develop into Lymphoid T cells, Lymphoid B cells, Myeloid and Monocytic cells.
The test is useful to detect translocation mutations in chromosomes INV 16 (P13;Q22), T(15;17) (Q21;Q22), T(8;21) (Q22;Q22).
The test is used for the detection of certain genetic mutations in ALL cases using FISH.
- Leukemia Test
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We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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