CD57 IHC

The CD57 IHC test measures the presence of CD57 protein on the surface of cells. CD57 is a transmembrane glycoprotein that plays a role in cell adhesion and signaling. Mature NK cells generally have lower CD57 expression compared to immature NK cells. 

IHC Single Marker with Reporting CD57 is done for several reasons, including:

• Help diagnose certain types of cancer, such as NK-cell lymphoma and T-cell lymphoma
• Determine the prognosis of certain types of cancer
• Monitor the progress of treatment for certain types of cancer
• Detect recurrence of certain types of cancer
• Distinguish between mature and immature NK cells
• Evaluate the differentiation status of NK cells and T lymphocytes

This test may be recommended if you:

• Symptoms of NK-cell lymphoma or T-cell lymphoma, such as fever, fatigue, and weight loss
• A family history of NK-cell lymphoma or T-cell lymphoma
• Abnormal blood or bone marrow tests that suggest the presence of NK-cell lymphoma or T-cell lymphoma

Abnormal results may indicate presence of immature NK cells or T cells, which could be associated with certain types of cancer. However, a positive test result does not necessarily mean that you have cancer. Other conditions can also cause a positive result, such as active infections or certain autoimmune diseases. 

• A small tissue sample will be taken from your body, usually through a biopsy.
• The tissue sample will be sent to the laboratory for analysis.
• The lab will use special staining techniques to identify and count CD57-positive cells in the tissue sample.

• Provide the original histopathology report and all relevant clinical and radiological details.
• Ensure that the tissue sample is properly prepared and preserved in paraffin blocks.
• Follow any specific instructions given by your doctor, such as fasting or stopping certain medications.

• Genetic testing to identify specific genetic mutations related to certain diseases
• Blood tests to assess overall immune function or look for specific disease markers
• Imaging tests such as CT scans or MRIs to evaluate the extent of a disease or tumour

• CD57 immunohistochemistry
• CD57 IHC
• CD57 immunostaining
• CD57 antibody staining
• CD57 marker test

Natural killer cell or NK cell deficiency is a condition characterised by low levels or impaired functioning of natural killer cells in the body. This immune system disorder can increase the risk of infections, certain cancers, and autoimmune disorders.