Endomysial Antibody IgG antibody Serum

Circulating IgG endomysial antibodies are present in 70% to 80% of patients with dermatitis herpetiformis or celiac disease, and in nearly all such patients who have high grade gluten-sensitive enteropathy and are not adhering to a gluten-free diet

Endomysial Antibody IgG (IgG-EMA) is a type of autoantibody found in the blood serum of individuals with certain autoimmune disorders, such as celiac disease.

The endomysium is a thin layer of connective tissue that surrounds individual muscle fibers, and IgG-EMA is an antibody that targets this tissue. In celiac disease, the immune system mistakenly identifies gluten, a protein found in wheat, barley, and rye, as a foreign invader and produces IgG-EMA antibodies that attack the endomysium in the small intestine. This can lead to inflammation and damage to the intestinal lining, which can cause a range of symptoms including diarrhoea, abdominal pain, and malabsorption of nutrients.

The detection of IgG-EMA in serum is commonly used as a diagnostic tool for celiac disease, In patients with low levels of IgA and children less than 3 years of age

Associated Tests:

E0027    Endomysial Antibody IgA antibody Serum

C0285    Coeliac disease profile-2 Comprehensive

C0079    Celiac Disease Profile

C0284    Coeliac Disease Profile-1

Written by: Supriya Kulkarni, Lead-Content & Training