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Endomysial Antibody IgG antibody Serum

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Circulating IgG endomysial antibodies are present in 70% to 80% of patients with dermatitis herpetiformis or celiac disease, and in nearly all such patients who have high grade gluten-sensitive enteropathy and are not adhering to a gluten-free diet

Endomysial Antibody IgG (IgG-EMA) is a type of autoantibody found in the blood serum of individuals with certain autoimmune disorders, such as celiac disease.

The endomysium is a thin layer of connective tissue that surrounds individual muscle fibers, and IgG-EMA is an antibody that targets this tissue. In celiac disease, the immune system mistakenly identifies gluten, a protein found in wheat, barley, and rye, as a foreign invader and produces IgG-EMA antibodies that attack the endomysium in the small intestine. This can lead to inflammation and damage to the intestinal lining, which can cause a range of symptoms including diarrhoea, abdominal pain, and malabsorption of nutrients.

The detection of IgG-EMA in serum is commonly used as a diagnostic tool for celiac disease, In patients with low levels of IgA and children less than 3 years of age

Associated Tests:

E0027    Endomysial Antibody IgA antibody Serum

C0285    Coeliac disease profile-2 Comprehensive

C0079    Celiac Disease Profile

C0284    Coeliac Disease Profile-1


Written by: Supriya Kulkarni, Lead-Content & Training



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Endomysial Antibody IgG antibody Serum Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Endomysial Antibody IgG antibody Serum with a clear pricing structure.

The Endomysial Antibody IgG antibody Serum Price in Mumbai is ₹ 3,000 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

Test helps in detection of IgG-endomysial antibodies for the diagnosis of dermatitis herpetiformis and celiac disease Monitoring adherence to gluten-free diet

Test is done on patient suffering from suspected Celiac disease

  • The Endomysial Antibody IgG antibody Serum Test is
  • often used to confirm coeliac disease in patients with low levels of IgA antibody
  • EMA IgG antibodies can also be used to monitor adherence to a gluten-free diet, as levels of the antibody typically decrease in response to the elimination of gluten from the diet.


The Endomysial Antibody IgG (EMA IgG) serum test measures the presence and levels of EMA IgG antibodies in the blood.

If EMA IgG antibodies are present in high levels, it is strongly indicative of celiac disease.

The test involves drawing a small amount of blood from a vein in your arm. A healthcare professional will clean the area with an antiseptic, wrap an elastic band around your upper arm to make the veins more visible, and insert a needle into a vein to collect the blood sample. You may feel a brief prick or stinging sensation when the needle is inserted, but the procedure is generally painless

No special preparation is required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status.


Some common symptoms that may warrant testing for celiac disease with the EMA IgG serum test include:

  • Gastrointestinal symptoms: Abdominal pain, bloating, gas, diarrhea, constipation, and nausea are common gastrointestinal symptoms associated with celiac disease.
  • Malabsorption and malnutrition: Celiac disease can lead to malabsorption of nutrients, which can result in malnutrition, weight loss, and fatigue.
  • Skin rash: A skin rash called dermatitis herpetiformis can occur in individuals with celiac disease, and may warrant testing for the condition.
  • Joint pain: Joint pain and inflammation are also common in individuals with celiac disease.
  • Unexplained iron deficiency anemia: Celiac disease can cause iron deficiency anemia that does not respond to iron supplements.

Delayed growth and puberty: Children with celiac disease may experience delayed growth and puberty due to malnutrition

There are several other blood tests that may be ordered in conjunction with the Endomysial Antibody IgG (EMA IgG) serum test to screen for and diagnose celiac disease. These tests may include:

  • Tissue transglutaminase antibodies (tTG IgA and tTG IgG): These tests measure the presence and levels of antibodies that target tissue transglutaminase, an enzyme that is important in the development of celiac disease.
  • This is used as a screening test and if positive is confirmed by antibody against Endomysium.
  • Deamidated gliadin peptide antibodies (DGP IgA and DGP IgG): These tests measure the presence and levels of antibodies that target deamidated gliadin peptides, a component of gluten. These tests are useful in cases where the EMA IgA and tTG IgA tests are negative, but celiac disease is still suspected.
  • Total serum IgA: This test measures the total amount of immunoglobulin A (IgA) in the blood. This test is important because a small percentage of individuals with celiac disease may have a deficiency in IgA, which can cause false negative results on the EMA IgA and tTG IgA tests.
  • Biopsy: In some cases, a biopsy of the small intestine may be performed to confirm the diagnosis of celiac disease.

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