Dexamethasone Suppression Test for Cortisol-Low Dose

This test measures the body's cortisol regulation by monitoring how cortisol levels respond to synthetic steroid intake. Monitoring cortisol changes helps evaluate adrenal gland function, stress response, and certain hormonal disorders impacting metabolism and immunity

• Diagnosing Cushing's syndrome or other hormonal disorders.
• Evaluating adrenal gland disorders.
• Assessing pituitary gland function.
• Monitoring treatment effectiveness in managing cortisol-related conditions.
• Investigating unexplained weight gain, high blood pressure, or excess hair growth.

This test is recommended:

• If Cushing’s syndrome symptoms are present, e.g., weight gain, hypertension.
• When evaluating adrenal or pituitary gland health.
• For monitoring Cushing’s syndrome treatment progress.
• If you have unexplained hormonal imbalance symptoms.
• As part of a comprehensive hormonal diagnostic workup.

Abnormal results indicate potential issues like Cushing’s syndrome, adrenal disorders, or pituitary dysfunction. Follow-up testing and consultation with your doctor are crucial to understanding these abnormalities and planning further investigations or treatments.

During this test:

• Baseline blood sample collection on day one.
• Oral dexamethasone intake every six hours for two days.
• Blood sample collection on the third day to check cortisol levels.
• The process is straightforward but involves multiple blood draws.

Before the test:

• Collect a basal blood sample on day one at 8 a.m.
• Take oral dexamethasone every six hours for two days.
• Follow any dietary or medication restrictions advised by your doctor.
• Ensure proper sample collection to avoid influencing the test results.

Other tests that may be ordered alongside this include:

• ACTH Stimulation Test: Evaluates adrenal function by measuring cortisol response to ACTH hormone stimulation.
• Midnight Cortisol Test: Assesses cortisol levels at night to diagnose conditions like Cushing’s disease.
• CRH Stimulation Test: Helps diagnose Cushing’s syndrome by measuring ACTH and cortisol responses to CRH hormone stimulation.

Low-Dose DST or Liddle’s Test

Cushing's syndrome is a disorder characterised by excessive cortisol levels in the body, causing various symptoms like weight gain, high blood pressure, and mood changes. It can result from adrenal gland tumours, prolonged steroid use, or pituitary gland abnormalities.