Deletion 1p/19q Co-deletion

This test evaluates genetic markers, specifically the deletion of chromosome arms 1p and 19q. These markers play a crucial role in diagnosing oligodendrogliomas, assisting in treatment decisions, and predicting patient prognosis based on tumour characteristics.

• To diagnose oligodendrogliomas accurately.
• To determine the prognosis and treatment options for glioma patients.
• To understand the genetic composition of brain tumours.
• To personalise treatment plans based on individual tumour characteristics.

This test is typically recommended:

• After a brain tumour diagnosis to better understand its genetic makeup.
• For patients with suspected or confirmed gliomas.
• To assess the effectiveness of ongoing treatment for brain tumours.
• When determining the best course of action for managing gliomas.

Abnormal results may suggest an increased risk of oligodendrogliomas. Other potential conditions linked to abnormal results include genetic syndromes or non-cancerous growths. Consult your doctor to interpret these findings accurately.

When undergoing this test:

• Your doctor will collect a sample of tumour tissue fixed in formalin.
• The tissue will be analysed using a method called fluorescence in-situ hybridization (FISH) to detect genetic alterations indicative of deletion 1p/19q.

• Ensure the tumour-containing tissue is appropriately fixed and embedded.
• Submit relevant clinical history and reports along with the sample.
• Follow the specific guidelines given by your healthcare provider on how to send the samples to the lab.
• No specific dietary or medication restrictions are typically needed.

Additional tests that might be recommended with Deletion 1p/19q Co-deletion include:

• Histopathology: Examining tissue changes under a microscope post-biopsy.
• Immunohistochemistry: Identifying specific proteins in tissues through staining techniques.
• CT Scan or MRI: Imaging tests used to visualise brain tumours and assess their size and location before treatment.

• Oligodendroglial deletion testing
• Chromosome arm 1p and 19q co-deletion analysis
• OligoFISH assay

Glioma is a type of brain tumour that forms from glial cells in the brain or spine. These tumours can be slow-growing or aggressive, affecting various brain functions depending on their location. Diagnosis often involves imaging studies and genetic tests like Deletion 1p/19q Co-deletion to tailor treatment plans effectively.