Autoimmune Encephalitis Panel-2

This test measures the levels of specific antibodies in the CSF, including NMDA, AMPA (GluR1 + GluR2), GABA B receptor, VGKC (LGI1, CASPR2), and DPPX. These antibodies are associated with autoimmune encephalitis and help in diagnosing and monitoring the condition.

This test is done to:

• Diagnose autoimmune encephalitis
• Identify the specific antibodies causing the condition
• Monitor the effectiveness of treatment
• Assess the risk of developing autoimmune encephalitis in individuals with certain symptoms or risk factors

Your doctor may recommend the Autoimmune Encephalitis Panel-2 test if you have:

• Symptoms of autoimmune encephalitis, such as seizures, memory problems, personality changes, or abnormal movements
• Risk factors for autoimmune encephalitis, like prior infection or tumor
• Inconclusive results from other diagnostic tests
• A need for monitoring your condition or treatment effectiveness

The presence of specific antibodies associated with autoimmune encephalitis suggests the presence of the condition. Your doctor will interpret the results considering your medical history, symptoms, and other diagnostic tests. Further evaluation may be required to confirm the diagnosis and determine appropriate treatment.

During this test:

• A sample of 2 ml CSF is collected in a sterile screw-capped container by a healthcare practitioner in a clinic or hospital
• The sample is sent to the laboratory for analysis
• The antibodies in the CSF are detected using the indirect immunofluorescence assay (IFA) method
• Test scheduling and reporting details can be obtained from your healthcare provider or the laboratory performing the test

Before the test:

• Your doctor may advise you to stop certain medications that could interfere with the test results
• Follow any fasting or dietary restrictions as instructed by your doctor
• Inform your healthcare provider about any recent infections or vaccinations
• Obtain specific instructions regarding medication usage, sample collection, and transportation from your healthcare provider or the laboratory
• Reach out to your healthcare provider about any specific requirements

Other tests that may be ordered along with the Autoimmune Encephalitis Panel-2 test include:

• Brain imaging (MRI or CT scan): To assess brain structure and look for abnormalities
• Electroencephalogram (EEG): To evaluate electrical brain activity
• Blood tests: To check for other autoimmune conditions or underlying causes of neurological symptoms

CSF Autoimmune Encephalitis Panel

Autoimmune encephalitis is a condition where the immune system mistakenly attacks healthy brain tissue, leading to inflammation and neurological symptoms. It can result from the production of antibodies against specific proteins in the brain. Prompt diagnosis and treatment are crucial for managing this condition effectively.