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Histopathology Test
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Sample Type
Blood
Recommended for
Male, Female
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Within 24 Hours
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Histopathology Test Details in Brief
| Also Known As | Histopathological Examination with Reflex IHC, Any Specimen |
|---|---|
| Purpose | To examine tissue samples under a microscope for detecting cancer, infections, and inflammation, and to confirm tumour types using immunohistochemistry (IHC) |
| Preparation | Clinical and radiological details must be provided |
| Fasting | Fasting not required |
| Reporting Time | After 5 days |
| Cost | 7,800 |
What is a Histopathology Test?
A histopathology test is a vital diagnostic examination where a pathologist studies your tissue sample (biopsy) under a microscope to detect diseases such as cancer, infections, and chronic inflammation. It provides detailed insights into how cells look and behave, helping doctors confirm or rule out serious conditions.
In this test, the collected tissue is preserved in formalin, processed, and embedded in wax to create thin slices. These slices are stained with special dyes and then carefully examined by a pathologist to assess the structure, arrangement, and health of the cells.
The findings reveal whether the tissue is normal, precancerous, or cancerous, and may also show the severity or stage of a disease. The histopathology report forms the foundation for accurate diagnosis, personalised treatment planning, and prognosis assessment.
What Does a Histopathology Test Measure?
The histopathology test provides a detailed analysis of your tissue structure and cell characteristics:
- Identifies abnormal or cancerous cell growth.
- Detects infections, inflammation, or tissue damage.
- Differentiates benign (non-cancerous) and malignant (cancerous) lesions.
- Determines tumour origin using immunohistochemistry (IHC).
- Helps in grading and staging of cancers for treatment planning.
Histopathology Test: Who Needs It and Why It’s Done
What Symptoms May Call for a Histopathology Test?
Doctors may recommend a histopathology test if you experience:
- Unexplained lumps, swelling, or growths in any part of the body.
- Persistent ulcers or lesions that do not heal.
- Abnormal imaging findings requiring tissue confirmation.
- Organ enlargement or structural changes noticed on ultrasound or CT.
- Signs of chronic infection or inflammation.
Who Should Get a Histopathology Test?
This test is advised for:
- Patients with suspected cancer or tumour.
- Individuals undergoing surgery or biopsy for diagnostic confirmation.
- Those with unexplained tissue changes or persistent inflammation.
- Patients requiring confirmation of infection, granuloma, or autoimmune disease.
Why is a Histopathology Test Done?
The test helps confirm or rule out disease by examining the tissue at a cellular level. It identifies the type and cause of the disease and helps doctors tailor the most suitable treatment approach.
Importance of a Histopathology Test
- A histopathology test is a cornerstone of modern diagnosis. It enables doctors to:
- Confirm cancer diagnosis and subtype.
- Assess infection or autoimmune disease.
- Guide personalised treatment strategies.
- Monitor response to treatment or disease progression.
- This test plays a crucial role in ensuring accurate, evidence-based care.
Histopathology Test Booking & Reports – Metropolis Healthcare
How to Book the Histopathology Test and Get Your Reports?
- Visit a Metropolis Lab or Partner Hospital
This test requires tissue sampling, so your doctor or surgeon will collect a specimen and send it to Metropolis Lab for analysis. - Safe Sample Handling
Samples are preserved in 10% Neutral Buffered Formalin in leak-proof containers to maintain integrity. - Accurate Laboratory Testing
Examination is done at NABL & CAP accredited laboratories by expert pathologists using advanced histopathology and immunohistochemistry techniques. - Quick & Reliable Reports
You will receive your results via email, WhatsApp, or can download them from the Metropolis Healthcare website or app.
Is Home Sample Collection for Histopathology Test Available Near You?
Home collection is not available for this test because it requires a tissue biopsy, which must be collected in a clinical or hospital setting under medical supervision.
How Long Does It Take to Get a Histopathology Test Report?
Reports are usually available within 5 days once the sample reaches the lab.
Note: Reporting time may vary based on your location.
Where Can I See or Get Histopathology Test Results?
You can access your test results via the Metropolis website, app, email, or WhatsApp. Physical copies can also be collected directly from the lab.
Interpreting Histopathology Test Results
What Your Histopathology Test Results May Indicate
| Parameter | Normal Finding | Abnormal Finding May Indicate |
|---|---|---|
| Any specimen with reflex IHC | Normal tissue architecture, absence of malignancy or inflammation | Cancer, infection, inflammation, autoimmune disorder, or tissue damage |
Understanding Abnormal Histopathology Test Results by Parameter
| Parameter | High/Positive Findings May Indicate | Low/Negative Findings May Indicate |
|---|---|---|
| Reflex IHC markers (e.g., CK7, ER, p53, p16, WT1, CA125) | Specific protein expression helps identify tumour origin and type (e.g., ovarian, breast, or lung cancer) | Absence or reduced expression helps exclude certain tumour types |
How Should You Prepare for a Histopathology Test?
You don’t need to do much before a histopathology test, but preparation is essential for safe tissue collection:
- Follow doctor’s instructions: Your doctor will advise on medications, fasting, or procedure-specific preparation.
- Inform your doctor: Tell your doctor about all medicines, allergies, or bleeding disorders.
- Provide medical history: Share any imaging reports or previous biopsy findings.
- Arrange assistance: Some biopsies are done under local or general anaesthesia; arrange for someone to accompany you.
How Is a Histopathology Test Done? (Step-by-Step Procedure)
The histopathology test follows these stages:
- Sample Collection: Your doctor removes a small piece of tissue during surgery or biopsy.
- Fixation: The tissue is preserved in 10% formalin to prevent decay.
- Processing: It is embedded in paraffin wax and cut into thin slices.
- Staining: Special stains such as H&E or IHC markers highlight cellular structures.
- Microscopic Examination: A pathologist studies the slides for cell changes and abnormalities.
- Reporting: Findings are recorded and reviewed, and a detailed diagnostic report is issued.
Conditions That May Affect Histopathology Test Accuracy
Several factors can influence the accuracy of your histopathology test results:
- Incorrect or missing clinical and radiological details..
- Prior chemotherapy or radiotherapy altering tissue morphology.
Diseases That a Histopathology Test Can Help Detect
- Cancers (e.g., breast, ovarian, lung, prostate, colon).
- Chronic inflammatory conditions (e.g., ulcerative colitis, hepatitis).
- Autoimmune diseases (e.g., lupus, vasculitis).
- Infectious diseases (e.g., tuberculosis, fungal infections).
- Benign growths, cysts, or tumours.
Histopathology Test Price in Different Cities
The cost of a Histopathology Test may vary depending on your location. Here's a table showing the approximate price range for the Histopathology Test at Metropolis Healthcare in major Indian cities:
|
City |
Approximate Cost (INR) |
|
₹ 6500 to ₹ 8000 |
|
|
₹ 6500 to ₹ 8000 |
|
|
₹ 6500 to ₹ 8000 |
|
|
₹ 6500 to ₹ 8000 |
The Histopathology Test cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive Histopathology Test prices across major cities in India.
References
- Rosai J., Ackerman L.V. (2011). Rosai and Ackerman’s Surgical Pathology. Elsevier Health Sciences.
- Kumar V., Abbas A.K., Aster J.C. (2021). Robbins and Cotran Pathologic Basis of Disease. Elsevier.
- Thunnissen E., et al. (2021). WHO Classification of Thoracic Tumours, 5th Edition. International Agency for Research on Cancer (IARC).
- Khoury J.D., et al. (2022). International Collaboration on Cancer Reporting: Dataset for the Reporting of Lung Carcinoma Histopathology Specimens. Histopathology, 80(4), 495–510. PMID: 35394815
- Lester S.C., et al. (2020). Manual of Surgical Pathology (4th Ed.). Elsevier.
Histopathology Test Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Histopathology Test with a clear pricing structure.
The Histopathology Test Price in Mankhurd is ₹ 7,800 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
The test examines tissue samples under a microscope to detect disease, inflammation, or cancer.
Reports are usually ready within 5 days after the sample reaches the lab.
Fasting is not required unless your doctor instructs otherwise for a specific biopsy procedure.
A doctor collects a small tissue sample during surgery or biopsy and sends it in formalin for testing.
Risks are minimal but may include mild pain, bleeding, or infection at the biopsy site.
Abnormal findings may suggest cancer, infection, inflammation, or other tissue diseases.
It helps identify most cancers and, with IHC testing, can pinpoint the exact type and origin.
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Why Metropolis?
Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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