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Anti GAD-65 Paraneoplastic Syndrome Serum

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GAD 65 Antibody Test Overview

Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. Patients with insulin-dependent diabetes mellitus (IDDM) often have antibodies to GAD65 and several other islet cell antigens.

The GAD65 antibody is a biomarker of autoimmune central nervous system (CNS) disorders and, more commonly, non-neurological autoimmune diseases, like Type 1 diabetes, autoimmune thyroid disease, and pernicious anemia.

 

Anti-GAD-65 paraneoplastic syndrome is a rare neurological disorder caused by the immune system attacking the body's nervous system, specifically the GAD-65 protein. The GAD-65 protein is an enzyme that is involved in the production of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps to regulate the communication between nerve cells in the brain and spinal cord.

 

In the case of anti-GAD-65 paraneoplastic syndrome, the immune system produces antibodies against the GAD-65 protein, leading to a reduction in GABA production and disrupting nerve cell communication.

 

The paraneoplastic aspect of this syndrome means that it is associated with certain types of cancer, typically small-cell lung cancer, breast cancer, or ovarian cancer. In some cases, anti-GAD-65 antibodies are produced as part of the body's immune response to the cancer, rather than as a direct result of the cancer itself.

 

Associated Tests:

Yo Antibody Neuronal antibody for Paraneoplastic syndromes Serum

Amphiphysin Antibody Neuronal Ag in Paraneoplastic Syndrome Serum

Hu Antibody Neuronal ag in Paraneoplastic syndromes Serum

Ri Antibody, Serum

 PNMA2 (MA2/TA) Antibody Serum

  Neuronal Antibody Profile

   Neuronal Antibody Profile-3

 

Written by : Supriya Kulkarni, Lead-Content & Training

 

 


 

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Anti GAD-65 Paraneoplastic Syndrome Serum Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Anti GAD-65 Paraneoplastic Syndrome Serum with a clear pricing structure.

The Anti GAD-65 Paraneoplastic Syndrome Serum Price in Mumbai is ₹ 6,500 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

GAD-65 antibody test is useful to diagnose Insulin dependent Diabetes mellitus (IDDM) and development of related endocrine disorders like Thyroiditis. It is also used to diagnose Stiff Man syndrome & automimmune encephalitis.

GAD 65 antibody test is performed for patients suspected of suffering from autoimmune diseases like Insulin Dependent Diabetes Mellitus, Stiff Man syndrome & autoimmune encephalitis.

Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic islet cells. Patients with insulin-dependent diabetes mellitus (IDDM) often have antibodies to GAD65 and several other islet cell antigens. Also High serum levels of antibodies to the synaptic enzyme glutamic acid decarboxylase (GAD-abs) is a very sensitive biomarker of stiff-person syndrome (SPS) and have also been described in subgroups of patients with limbic encephalitis (LE), cerebellar ataxia,epilepsy, and isolated cases of palatal tremor, as well as downbeat or periodic alternating nystagmus. Patients with GAD-abs must be screened for an underlying cancer if they have clinical presentations different from those typically associated with this autoimmunity or develop classic PNS.

  • To help diagnose anti-GAD-65 paraneoplastic syndrome, a rare autoimmune disorder that affects the nervous system.
  • To identify the presence of anti-GAD-65 antibodies in the blood, which are strongly associated with anti-GAD-65 paraneoplastic syndrome.
  • To help confirm a suspected diagnosis of anti-GAD-65 paraneoplastic syndrome based on the patient's symptoms and medical history.
  • To monitor the progression of the condition and the effectiveness of treatment over time.
  • To assess the risk of developing anti-GAD-65 paraneoplastic syndrome in patients with certain types of cancer, such as small-cell lung cancer, breast cancer, or ovarian cancer.
  • To rule out other potential causes of the patient's symptoms, such as multiple sclerosis or other autoimmune disorders.
  • To guide treatment decisions and help healthcare providers develop an individualized treatment plan for patients with anti-GAD-65 paraneoplastic syndrome

The Anti GAD-65 Paraneoplastic Syndrome Serum test measures anti-GAD-65 antibodies in the blood.

 

If the results of the anti-GAD-65 paraneoplastic syndrome serum test are abnormal, it may indicate the presence of anti-GAD-65 antibodies in the blood, which is strongly associated with anti-GAD-65 paraneoplastic syndrome.

The test involves drawing a small amount of blood from a vein in your arm. A healthcare professional will clean the area with an antiseptic, wrap an elastic band around your upper arm to make the veins more visible, and insert a needle into a vein to collect the blood sample. You may feel a brief prick or stinging sensation when the needle is inserted, but the procedure is generally painless.

 

No special preparation is required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status

The doctor may advise this test if you have symptoms of neurological disorders including stiffness, spasms, and weakness in the muscles, as well as difficulty with coordination, balance, and movement. Other symptoms may include cognitive problems, such as memory loss, difficulty with language, and trouble with problem-solving and decision-making.

Diagnosis of anti-GAD-65 paraneoplastic syndrome typically involves a combination of clinical evaluation, neurological testing, and laboratory tests to detect the presence of anti-GAD-65 and other neurological antibodies in the blood.

 

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