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Alpha Mannosidase Test
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
WIthin 15 Days
Blood test at Home
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Alpha Mannosidase Test Overview
Alpha-mannosidase is an enzyme that breaks down complex carbohydrates in our bodies. It helps remove certain sugar molecules from different substances in our cells. When this enzyme doesn't function properly, it can lead to a condition called alpha-mannosidosis, causing various health problems.
The Alpha Mannosidase test or the Alpha Mannosidase blood test measures the activity of the alpha-mannosidase enzyme, crucial for breaking down mannose-containing complex oligosaccharides. This enzyme deficiency leads to alpha-mannosidosis, a rare lysosomal storage disorder that affects cellular waste processing. Symptoms include developmental delays, skeletal abnormalities, immune deficiencies, and hearing loss.
The Alpha Mannosidase test is typically conducted using a blood or tissue sample and helps confirm the diagnosis of alpha-mannosidosis, particularly in individuals showing related symptoms or with a family history of the disorder. Early diagnosis through this test is vital for managing the condition and planning appropriate treatments or supportive care strategies.
Reasons for Undergoing the Alpha Mannosidase Test
The Alpha Mannosidase test is a crucial diagnostic tool for various reasons. These include:
- Diagnosing alpha mannosidosis, a rare genetic disorder caused by a deficiency of the lysosomal alpha-mannosidase enzyme
- Differentiating alpha mannosidosis from other lysosomal storage diseases like mucopolysaccharidosis (MPS), especially when MPS test results are negative
- Monitoring patients undergoing treatment for alpha mannosidosis to assess the effectiveness of therapeutic interventions
- Clarifying molecular findings in the MAN2B1 gene, which is responsible for producing the alpha-mannosidase enzyme
List of Parameters Considered During the Alpha Mannosidase Test
The Alpha Mannosidase blood test measures several key parameters:
- Alpha-Mannosidase Enzyme Activity: This is the primary parameter, measuring the activity of the acid alpha-mannosidase enzyme in leukocytes, cultured fibroblasts, or dried blood spots. Reduced or absent enzyme activity indicates alpha mannosidosis.
- Urinary Oligosaccharides: Although not diagnostic on its own, elevated levels of certain mannose-rich oligosaccharides in urine can suggest alpha mannosidosis and prompt further testing.
Alpha Mannosidase Test Preparation
Preparation for the Alpha Mannosidase test typically involves no special requirements. However, your doctor may advise specific guidelines based on your medical history. Inform the healthcare provider about any medications or supplements you are taking, as these could affect the Alpha Mannosidase blood test results. Follow all instructions to ensure accurate measurements.
Alpha Mannosidase Test Results & Interpretation
Alpha Mannosidase test results measure the enzyme's activity in blood or tissue samples to evaluate for alpha-mannosidosis. Low enzyme activity indicates a deficiency, confirming the diagnosis of this rare lysosomal storage disorder. This condition can lead to developmental delays, skeletal abnormalities, immune deficiencies, and other symptoms. Results are analysed alongside clinical signs, genetic testing, and medical history to provide a comprehensive understanding. A normal enzyme level typically rules out alpha-mannosidosis.
Early interpretation of results by a specialist is crucial for planning treatment strategies, including enzyme replacement therapy or supportive care, and managing the progression of associated symptoms effectively.
Home Collection for Alpha Mannosidase Test Near You
Metropolis Healthcare offers a convenient home sample collection service for the Alpha Mannosidase test, ensuring you can access this critical diagnostic tool without compromising on quality or accuracy. A trained phlebotomist will visit your home to collect the required blood samples, prioritising your comfort and safety while adhering to stringent sample handling standards. You can trust Metropolis Healthcare to deliver timely and reliable results, enabling you to take proactive steps in managing your health.
With a commitment to making healthcare accessible and providing quality diagnostic solutions, Metropolis Healthcare brings the Alpha Mannosidase test to your doorstep, ensuring a seamless testing experience.
Alpha Mannosidase Test Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Alpha Mannosidase Test with a clear pricing structure.
The Alpha Mannosidase Test Price in Mumbai is ₹ 6,300 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
The test measures the amount of alpha-mannosidase enzyme in the blood.
- To diagnose alpha-mannosidosis and other conditions that affect alpha-mannosidase levels.
- To monitor treatment effectiveness for alpha-mannosidosis.
- To help doctors understand and diagnose other genetic conditions.
This test is recommended if
- You have symptoms of alpha-mannosidosis, such as developmental delays or neurological problems.
- You have a family history of alpha-mannosidosis or other genetic conditions.
- You are pregnant and your baby is at risk for genetic disorders.
- You have unexplained symptoms or health issues that your doctor is unable to diagnose.
If your test results show levels below this range, it could be indicative of alpha-mannosidosis or another condition that affects alpha-mannosidase levels.
The Alpha Mannosidase blood test is a simple blood test. Here’s what you can expect:
- A healthcare professional will insert a needle into your arm and draw a sample of blood.
- The procedure is usually painless, but some people may feel a brief pinch or sting.
There are no specific preparations required for the test. However, it is recommended that you consult with your healthcare provider before taking the test, as they may have specific instructions or recommendations based on your individual medical history and current health status.
Other tests that may be recommended alongside the Alpha Mannosidase Blood Test include:
- Complete blood count (CBC) and white blood cell differential: These tests evaluate overall health and immune function.
- Urine tests: These tests look for substances that indicate kidney or liver problems.
- DNA testing: This test can confirm a diagnosis of alpha-mannosidosis or other genetic conditions.
Alpha-mannosidase deficiency assay or alpha-mannosidase activity test.
A rare genetic disorder, Alpha-mannosidosis arises when the body lacks the enzyme Alpha Mannosidase. This enzyme helps break down sugars in the body. This causes various problems, such as learning difficulties, physical abnormalities, hearing loss, and a weak immune system.
The Alpha Mannosidase test is a diagnostic tool that measures the activity of the alpha-mannosidase enzyme, which is essential for breaking down mannose-containing complex oligosaccharides. It helps diagnose alpha mannosidosis, a lysosomal storage disorder.
Yes, the Alpha Mannosidase test can confirm an alpha mannosidosis diagnosis by measuring enzyme activity. Low or absent activity is indicative of the disease.
You can book a home sample collection for the Alpha Mannosidase blood test through various diagnostic center websites or by contacting them directly. Many labs, such as Metropolis Healthcare, offer online booking services for your convenience.
Normal alpha-mannosidase enzyme activity levels vary, but significantly reduced or absent activity is diagnostic of alpha mannosidosis. The conducting laboratory may provide specific normal ranges.
Currently, there is no cure for alpha mannosidosis. Treatment focuses on managing symptoms and improving quality of life through options like enzyme replacement therapy, physical therapy, and supportive care.
No, there is no cure for alpha mannosidosis. Treatment primarily aims to manage symptoms and slow down the disease's progression.
The Alpha Mannosidase test is used to diagnose alpha mannosidosis and differentiate it from other lysosomal storage diseases.
The Alpha Mannosidase test is performed when there is clinical suspicion of alpha mannosidosis or when other diagnostic tests for lysosomal storage diseases are negative. It is not recommended for regular screening unless clinically indicated.
There is no specific time recommended for the test; it can be done at any time as per the healthcare provider's advice.
No, fasting is not required for the Alpha Mannosidase test.
Low alpha-mannosidase enzyme activity levels strongly suggest a diagnosis of alpha-mannosidosis, a rare lysosomal storage disorder. This indicates that the individual may have a deficiency in breaking down mannose-containing complex oligosaccharides, leading to the accumulation of harmful substances in cells. Such results, combined with clinical symptoms and genetic testing, help confirm the condition and guide healthcare providers in creating an effective treatment or management plan for the affected individual.
The primary parameter measured in the Alpha Mannosidase test is the activity of the alpha-mannosidase enzyme in cells, typically in leukocytes.
The Alpha Mannosidase test involves collecting a blood sample, typically from a vein in the arm, which is then sent to a laboratory to measure the alpha-mannosidase enzyme activity.
The Alpha Mannosidase test should be done when clinically indicated, such as when symptoms suggestive of alpha mannosidosis are present or when differential diagnosis is needed.
The actual blood collection process is quick, but the time it takes to get the results can vary depending on the laboratory.
The Alpha Mannosidase test reports are usually available 10 days based on the day/date when the sample is collected and processed.
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