TPMT and NUDT15 Gene Analysis

This test measures specific genetic markers that can affect how your body metabolises certain medications. By analysing these genes, we can determine if you have variants that may make you more sensitive or resistant to certain drugs. This information helps guide personalised treatment plans.

This test is done for several reasons, including:

• To identify individuals at higher risk of adverse drug reactions
• To optimise drug selection and dosages based on genetic variations
• To personalise treatment plans for diseases like leukemia, Crohn's disease, and autoimmune disorders
• To minimise side effects and improve treatment outcomes

Your doctor may recommend the TPMT and NUDT15 Gene analysis if:

• You are starting medications like azathioprine, mercaptopurine, or thioguanine
• You have a history of severe adverse reactions to these medications
• You have a family history of drug sensitivity or resistance
• You have certain medical conditions where these drugs are commonly prescribed

The TPMT gene has normal, intermediate, and poor metaboliser statuses, while the NUDT15 gene has normal and variant statuses. Abnormal results may indicate a higher risk of experiencing side effects or therapeutic failure with certain medications. Your doctor will consider these results along with other factors to determine the best treatment options for you.

• A blood sample is collected for TPMT and NUDT15 Gene analysis
• The laboratory uses Sanger Sequencing to analyze the sample
• The process identifies genetic variations in TPMT and NUDT15 genes
• Results from the analysis provide essential information for your healthcare provider

Before the test:

• Fill out the genetic history form provided by your doctor
• There are no specific dietary or medication restrictions before this test
• If you are taking any relevant medications, inform your doctor
• Follow any additional instructions given by your healthcare provider

Other tests that may be ordered alongside TPMT and NUDT15 Gene analysis include:

• Drug level monitoring to ensure appropriate drug dosages
• Liver function tests to assess liver health
• Complete blood count to check overall blood cell counts
• Inflammatory bowel disease genetic panel to assess genetic risk factors for Crohn's disease and ulcerative colitis

TPMT and NUDT15 Genotyping or TPMT and NUDT15 DNA Sequencing

Thiopurine-induced toxicity refers to adverse reactions or side effects caused by medications like azathioprine, mercaptopurine, or thioguanine. These drugs are commonly used to treat conditions like leukemia, autoimmune disorders, and inflammatory bowel disease. TPMT and NUDT15 gene analysis help identify individuals at higher risk for thiopurine-induced toxicity and guide personalised treatment approaches.