What does BCR-ABL Breakpoint Analysis measure?

This test detects the breakpoints (major, minor, and micro translocations) of BCR-ABL fusion gene.

Why is BCR-ABL Breakpoint Analysis done?

• To diagnose CML • To detect major, minor, and micro translocations of BCR-ABL • To assess the effectiveness of treatment for CML • To guide targeted therapy decisions • To monitor disease progression and response to treatment

When is BCR-ABL Breakpoint Analysis recommended and who should take the test?

This test is recommended for individuals who • are suspected to have CML, • have symptoms such as fatigue, unexplained weight loss, or enlarged spleen, or • are undergoing treatment for CML to assess response and monitor treatment effectiveness.

What if the results of the BCR-ABL Breakpoint Analysis are abnormal?

Abnormal results may indicate the presence of major, minor, or micro translocations of BCR-ABL associated with CML.

What to expect during the BCR-ABL Breakpoint Analysis?

A 3 ml bone marrow sample will be collected in an EDTA Vacutainer. The sample will be sent to the laboratory for processing through the Real-time PCR method.

What preparations are required before the BCR-ABL Breakpoint Analysis?

• No dietary restrictions or specific preparations are required before this test. • Inform your doctor if you have any specific requirements.

What other tests may be ordered with BCR-ABL Breakpoint Analysis?

Other tests that may be ordered alongside BCR-ABL Breakpoint Analysis include • Complete blood count (CBC) • Peripheral blood smear examination • Other molecular tests for specific genetic mutations associated with hematological malignancies

What is Chronic Myeloid Leukaemia?

Chronic myeloid leukaemia is a type of cancer that affects the white blood cells. It is charactersed by the abnormal fusion of two genes, BCR and ABL, resulting in the production of a protein called BCR-ABL. CML leads to an overproduction of abnormal white blood cells.

BCR-ABL Breakpoint Analysis Qualitative By Real Time PCR - Bone Marrow in Pune

Also known as: BCR-ABL Breakpoint Detection by RT-PCR, EDTA Bone Marrow

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Overview

BCR-ABL Breakpoint Analysis Qualitative by Real-Time PCR, performed on bone marrow samples, is a diagnostic test utilized to diagnose cases of Chronic Myeloid Leukemia (CML). The test has clinical utility in detecting major, minor, and micro translocations of the BCR-ABL fusion gene, which is characteristic of CML. CML is a myeloproliferative neoplasm caused by the fusion of the BCR and ABL genes, resulting in the production of the BCR-ABL fusion protein. By analyzing the breakpoints of the BCR-ABL fusion gene using real-time PCR, this test confirms the presence of the fusion gene and aids in the diagnosis of CML. The detection of major, minor, and micro translocations provides valuable information regarding the specific genetic alterations involved in the disease. This information is essential for determining appropriate treatment strategies and monitoring disease progression in CML patients.

BCR-ABL Breakpoint Detection by RT-PCR, EDTA Bone Marrow Price in Pune

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the BCR-ABL Breakpoint Detection by RT-PCR, EDTA Bone Marrow with a clear pricing structure

The price of BCR-ABL Breakpoint Detection by RT-PCR, EDTA Bone Marrow in Pune is ₹ 4,755

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

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