BCR-ABL Breakpoint Analysis Qualitative By Real Time PCR - Bone Marrow

This test detects the breakpoints (major, minor, and micro translocations) of BCR-ABL fusion gene.

• To diagnose CML • To detect major, minor, and micro translocations of BCR-ABL • To assess the effectiveness of treatment for CML • To guide targeted therapy decisions • To monitor disease progression and response to treatment

This test is recommended for individuals who • are suspected to have CML, • have symptoms such as fatigue, unexplained weight loss, or enlarged spleen, or • are undergoing treatment for CML to assess response and monitor treatment effectiveness.

Abnormal results may indicate the presence of major, minor, or micro translocations of BCR-ABL associated with CML.

A 3 ml bone marrow sample will be collected in an EDTA Vacutainer. The sample will be sent to the laboratory for processing through the Real-time PCR method.

• No dietary restrictions or specific preparations are required before this test. • Inform your doctor if you have any specific requirements.

Other tests that may be ordered alongside BCR-ABL Breakpoint Analysis include • Complete blood count (CBC) • Peripheral blood smear examination • Other molecular tests for specific genetic mutations associated with hematological malignancies

BCR-ABL Fusion Gene Analysis

Chronic myeloid leukaemia is a type of cancer that affects the white blood cells. It is charactersed by the abnormal fusion of two genes, BCR and ABL, resulting in the production of a protein called BCR-ABL. CML leads to an overproduction of abnormal white blood cells.