Phospholipid profile IgG

Phospholipid Profile IgG includes tests to detect antibodies against Phosphatidyl Choline, Phosphatidyl Ethanolamin, Phosphatidyl Inositol, Phosphotidylserine, Cardiolipin and Beta2 Glycoproteins in the blood serum.

The test is done to diagnose and detect causes for:

• Coagulation disorders like thrombosis. 
• Failed pregnancies or spontaneous abortions
• Pre-term delivery, and pre-eclampsia.
• Autoimmune disorders like SLE.

• Patients experiencing consecutive spontaneous abortions.
• Patients having difficulty conceiving or experiencing multiple failed pregnancies.
• Women having difficulty in the current or previous pregnancy; like foetal growth retardation, early neonatal deaths, stillborn.
• Patients at risk for pre-eclampsia or pre-term delivery.
• Patients with coagulation disorders like thrombophilia.

This test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

No special precautions.

Cardiolipin AntibodyACL- IgG and Ig M

Anti-cardiolipin antibodies (ACA) and are associated with thrombotic states and can cause recurrent abortions and infertility.

Beta 2 glycoprotein IgG & M

Presence of IgG antibodies are considered as an independent risk factor for thrombosis and pregnancy complications. Persistent positive test spaced at least 12 weeks apart is significant for Anti Phospholipid Syndrome diagnosis.

This profile also detects the presence or absence of autoantibodies against various phospholipids as well.

•  Phosphatidyl Choline test
•  Phosphatidyl Ethanolamin test
• ,Phosphatidyl Inositol test
•  Phosphotidylserine test
•  Cardiolipin test
•  Beta2 Glycoprotein 1 test
•  Cardiolipin,and Beta 2 Glycoprotein test

These are types of phospholipids that have a role in blood clotting mechanism, liver function, cognitive function and lipid metabolism. Antibodies against these may be seen in certain autoimmune disorders that may lead to disturbances in blood clotting.

Anti-cardiolipin antibodies (ACA) and are associated with thrombotic states and can cause recurrent abortions and infertility.

Antiphospholipid antibodies(APA) are important in the etiology of recurrent thrombosis & pregnancy loss in patients with Antiphospholipid antibody syndrome(APS). Beta-2- glycoprotein is one of the plasma binding proteins useful in regulating the intrinsic coagulation pathway. Beta 2 glycoprotein IgG and IgM are considered as an independent risk factor for thrombosis and pregnancy complications.