ANA Profile Antibody To SSA, SSB, SM, JO1, U1SNRNP, Centromere, RNP-SM, SCL-70 and ds DNAby EIA in Lucknow
₹5000
₹5000
ANA test measures the amount of anti-nuclear antibody in the blood
To evaluate for certain autoimmune disorders, such as systemic lupus erythematosus (SLE) and Sjogren syndrome, among other types.
Your doctor may recommend this test for you if he sees the symptoms of systemic auto immune disease which include:
- Low-grade fever
- Persistent fatigue, weakness
- Joint pain
- Red rash
- Skin sensitivity to light
- Hair loss
- Muscle pain
- Numbness or tingling in the hands or feet
Antinuclear antibodies (ANA) are a group of antibodies produced by an individual's system when it fails to adequately distinguish between "self" and "nonself." These antibodies, referred to as autoantibodies, attack the body's own healthy cells and cause signs and symptoms such as tissue and organ inflammation, joint and muscle pain, and fatigue. ANA specifically target substances found in the nucleus of a cell, hence the name "antinuclear." The ANA test identifies the presence of these autoantibodies in the blood.
The presence of ANA could also be a marker of an autoimmune process and is related to several autoimmune disease s but is most ordinarily seen with the autoimmune disorder systemic lupus erythematosus (SLE).
The ANA test is one among the first tests for helping to diagnose a suspected autoimmune disease or ruling out other conditions with similar signs and symptoms. As such, it's often followed by other tests for autoantibodies which will help to determine a diagnosis. These may include, for instance, an ENA panel, anti-dsDNA, anti-centromere and/or anti-histone test.
Reference Values Of ANA Profile Antibody To SSA, SSB, SM, JO1, U1SNRNP, Centromere, RNP-SM, SCL-70 and ds DNAby EIA
ANA is reported as a "titer". Low titers are in the range of 1:40 to 1:60. A positive ANA test is of much more importance if you also have antibodies against the double-stranded form of DNA. The presence of ANA does not confirm a diagnosis of systemic lupus erythematosus (SLE).
Interpretations
A positive ANA test result means that autoantibodies are present. In a person with signs and symptoms, this suggests the presence of an autoimmune disease, but further evaluation is required to assist in making a final diagnosis.
A negative ANA result makes SLE an unlikely diagnosis. It usually is not necessary to immediately repeat a negative ANA test; however, due to the episodic nature of autoimmune diseases, it may be worthwhile to repeat the ANA test at a future date if symptoms recur.
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