Maternal screen (Quadruple marker test) Third trimester in Khanna
This test is done between the 16th and 18th weeks of pregnancy. Your doctor may order this test for you up to the 22nd week of pregnancy.
- The pregnant woman is 35 years old or older
- Dual Marker tests were abnormal
- There is a family history of birth defects
- The pregnant woman is diabetic and under insulin medication
- If it is suspected that the pregnant woman was exposed to a high dose of radiation
- A viral infection during pregnancy
This test is conducted between the 15th and 20th weeks of pregnancy. The test is often most recommended under the following scenarios
Quadruple Marker Test (Also called Quad screen) – This includes
- AFP (Alpha-fetoprotein)
- uE3 (unconjugated Estriol)
- hCG (Human Chorionic gonadotrophin)
- Inhibin A
AFP or alpha fetoprotein is made by the foetal liver and some amount of this substance gets into the mother’s blood. Higher levels of AFP are seen in Neural tube defects and levels are decreased in Down syndrome and Edward syndrome.
- What if I am a man and have high AFP level?
- What if I am a non-pregnant woman and have high AFP level?
- In men, non-pregnant women, and children, AFP in the blood can mean certain types of cancer, especially cancer of the testicles, ovaries, stomach, pancreas, or liver are present.
uE3 (Unconjugated Estriol)
Estriol is a hormone produced by the placenta, using ingredients made by the fetal liver and adrenal glands. In pregnancies with Down Syndrome or Edward Syndrome, it is observed that the Estriol levels are reduced.
Inhibin - A
Inhibin-A is secreted by the ovary and the role is to ‘’inhibit’’ the production of FSH, follicle stimulating hormone. Higher levels of Inhibin A is measured in the blood of mothers of fetuses with Down syndrome.
Reference Values Of Maternal screen (Quadruple marker test) Third trimester
Your doctor will help you interpret your report basis your test results
Increased risk for HCG uE3 AFP Inhibin A
Open spina bifida Normal Normal High Not Applicable
Anencephaly Low Low High Not Applicable
Down syndrome High Low Low High
Edwards syndrome Low Low Variable Not Applicable
If a screen is positive, more tests are needed that can confirm the diagnosis and state the condition definitively. These include high-resolution ultrasound and perhaps amniocentesis followed by chromosome analysis. These follow-up tests are used to help women and their healthcare practitioners make decisions about managing their pregnancies.
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Frequently Asked Questions
Yes our laboratory is accredited by the NABL (National Accreditation Board of Testing and Calibration of Laboratories) India & College of American Pathologists (CAP). This accreditation process is carried out every 2 years for NABL & annually for CAP with periodic internal audits carried out twice in a year. All our aforementioned tests are accredited by NABL & CAP.
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