CD34 IHC

The CD34 IHC test is a laboratory procedure that uses antibodies to detect the presence of CD34 protein in tissues.

The CD34 test is done for several reasons, including:

• Determining the prognosis (likely outcome) of certain cancers. CD34 is a highly sensitive and specific marker for GISTs, seminomas, and melanomas. The test can also be used to help diagnose other types of cancer, such as dermatofibrosarcoma protuberans and angiosarcoma.
• Assessing the effectiveness of cancer treatments
• Evaluating bone marrow and stem cell transplantation

The CD34 test may be recommended if you:

• Have symptoms or risk factors for leukaemia, lymphoma, or other blood disorders
• Are undergoing treatment for these conditions to assess response
• Are preparing for a stem cell transplant
• Need to evaluate your bone marrow function or overall health status

Abnormal results from the CD34 IHC test could indicate the presence of gastrointestinal stromal tumors (GISTs), seminomas, melanomas, dermatofibrosarcoma protuberans (DFSPs), or angiosarcomas, but further testing is necessary to confirm the diagnosis and determine the appropriate course of treatment.

• A small sample of blood or bone marrow is collected.
• The sample is sent to a laboratory for analysis.
• The CD34 levels are measured using specialised techniques.
• The results are shared with your doctor, who will interpret them and discuss them with you.

Generally, there are no specific preparations required for the CD34 IHC test. However, it is advisable to consult your doctor beforehand to discuss any medications you might be taking, as certain medications could interfere with the test results. Additionally, if you have any allergies or bleeding disorders, inform your doctor to ensure the test is performed safely.

• Complete Blood Count (CBC): This test provides information about various components of your blood, such as red blood cells, white blood cells, and platelets.
• Bone Marrow Biopsy: This procedure involves collecting a small sample of bone marrow to evaluate its cellular composition and identify any abnormalities.
• Flow Cytometry: This test uses fluorescence to detect and analyse specific cell types in blood or bone marrow samples.

• IHC single marker with reporting CD34
• CD34 immunohistochemistry (IHC) test
• CD34 staining test

Gastrointestinal stromal tumors (GISTs) are rare tumors that arise from the interstitial cells of Cajal (ICCs), specialized cells found in the walls of the gastrointestinal (GI) tract. These cells play a role in the movement of food through the GI tract. GISTs can occur in any part of the GI tract, but they are most common in the stomach and small intestine.