C4d IHC
Overview
C4d is a fragment of complement protein C4 that is deposited on the surface of antibodies. The C4d IHC test is used to diagnose antibody-mediated rejection (AMR) of solid organ transplants. AMR is a type of organ rejection that is caused by antibodies that attack the transplanted organ. The C4d IHC test is particularly useful for diagnosing AMR in the kidney, heart, and lung.
C4d IHC Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the C4d IHC with a clear pricing structure.
The C4d IHC Price in Tardeo is ₹ 2,545 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
This test measures the levels of C4D, a specific protein marker, in tissue samples.
This test is done for several reasons, including:
- Diagnosing and monitoring conditions involving complement system activation
- Assessing the effectiveness of treatment for immune-related disorders
- Evaluating transplant rejection in organ transplantation
- Identifying autoimmune diseases and vasculitis
Your doctor may recommend this test if you:
- Have symptoms suggestive of immune-related disorders, such as kidney problems, joint pain, or skin rashes
- Have a known autoimmune disease or vasculitis
A positive C4d IHC test result means that C4d is present on the surface of antibodies in the transplanted organ. This suggests that the organ is being attacked by antibodies, and that AMR is likely the cause of the symptoms.
During the test, a tissue sample will be collected, typically from a previous biopsy or surgery. The sample will be analysed in the laboratory using immunohistochemical techniques to detect the presence and location of the C4D protein. The procedure is painless, but it requires previous tissue sampling.
No specific preparations are needed for this test. However, it is essential to provide the original histopathology report, relevant clinical details, and any additional radiological information related to your condition. Please speak to your healthcare provider for any specific requirements and instructions.
- Complete Blood Count (CBC): Evaluates different types of blood cells and their levels
- Kidney Function Tests: Measures various parameters to assess kidney health and function
- Rheumatoid Factor Test: Determines the presence of antibodies associated with rheumatoid arthritis and other autoimmune conditions
- Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Test: Detects antibodies seen in certain types of vasculitis
- IHC Single Marker with Reporting C4D
- Immunohistochemistry for C4d protein localization and quantification
Autoimmune disorders occur when the immune system mistakenly attacks healthy tissues and organs, causing inflammation and damage. Examples include lupus, rheumatoid arthritis, vasculitis, and multiple sclerosis. These conditions can affect various parts of the body and have diverse symptoms.
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