Leukemia Panel (ALL) by FISH, Heparin Blood

BCR-ABL1, ETV6-RUNX1, TCF3, and KMT2A(MLL) gene rearrangement are specific genetic abnormalities commonly found in certain types of leukaemia. These gene rearrangements occur due to chromosomal abnormalities and can have significant implications for the diagnosis, prognosis, and treatment of leukaemia. The "Leukemia panel by FISH - ALL, Leukemic Blood" test is a diagnostic tool used to detect specific genetic abnormalities in acute lymphoblastic leukemia (ALL) through fluorescence in situ hybridization (FISH) analysis. The FISH probes utilized in this panel target key genetic rearrangements, including BCR-ABL1, ETV6-RUNX1, TCF3, and KMT2A(MLL) gene rearrangements. The clinical utility of this test lies in its ability to identify these specific genetic alterations in the leukemic blood, which is crucial for accurate diagnosis, risk stratification, and treatment planning in ALL patients. By analyzing these genetic markers, healthcare professionals can determine the presence and significance of these rearrangements, helping to provide personalized and targeted therapies to improve patient outcomes.