Apolipoproteins B/A1, Serum

Apolipoproteins are proteins that attach to the lipids to transport the cholesterol through the blood. Two types of Apolipoproteins are mainly measured, Apolipoprotein A and Apolipoprotein B. Apolipoprotein A is mainly attached to HDL (good cholesterol) and mainly helps to eliminate the bad cholesterol from the blood. Apolipoprotein B attaches to LDL (bad cholesterol) and contributes to heart diseases by leading to formation of plaques or clogging of arteries.

Apolipoprotein B (ApoB) and Apolipoprotein A1 (ApoA1) are two forms of apolipoproteins (proteins found in lipoproteins) that transport fats like cholesterol in the blood.

ApoB, also known as beta-lipoprotein, is mostly found in low-density lipoproteins (LDL). It is often known as "bad cholesterol" because high LDL cholesterol levels are linked with a higher risk of heart disease.

ApoA1, also known as alpha-lipoprotein, is predominantly found in high-density lipoproteins (HDL). It is sometimes referred to as "good cholesterol" because high levels of HDL cholesterol in the blood are associated with a lower risk of heart disease.

Who requires Apolipoprotein B/A1 (ApoB/A1) test?

• Individuals who are at risk for heart diseases such as those with high cholesterol or a family history of heart disease.
• Patients with a medical history of heart diseases, such as a heart attack or stroke.
• Patients suffering from metabolic disorders such as diabetes mellitus or obesity.
• Patients taking lipid-lowering medications such as statins or fibrates.
• Testing for liver disease or metabolic disorders.
• Monitoring lipid levels after making lifestyle changes or receiving treatment for lipid disorders.

Written by: Dr.Shibani R, Medical Writer, Medical Affairs