Dehydroepiandrostenedione (DHEA)

The DHEA Serum Test quantifies the concentration of dehydroepiandrosterone in the blood serum.

The test is conducted for the following reasons:

• To diagnose and evaluate disorders affecting the adrenal glands, particularly congenital adrenal hyperplasia (CAH).

• To assess hormonal imbalances and their potential effects on various physiological processes.

• To investigate androgen excess or deficiency, which may lead to symptoms such as abnormal hair growth, irregular menstruation, or changes in sexual characteristics.

The DHEA Serum Test is recommended in specific clinical situations, including:

• Patients showing symptoms of adrenal gland dysfunction, such as virilization (masculinization) in females or ambiguous genitalia in newborns.

• Individuals with a family history of congenital adrenal hyperplasia (CAH) or other adrenal disorders.

• Patients requiring assessment of androgen levels for diagnostic or monitoring purposes.

• In cases where hormonal imbalances are suspected and may impact health and well-being.

The results of the DHEA Serum Test provide information about the concentration of dehydroepiandrosterone in the blood serum. Abnormal DHEA levels may indicate adrenal gland dysfunction, hormonal imbalances, or conditions like congenital adrenal hyperplasia. Interpretation of the results depends on the clinical context and the patient's symptoms.

The test involves a blood draw, where a healthcare professional collects a blood sample from a vein, usually in the arm. The procedure is relatively quick and minimally invasive.

Preparation for the DHEA Serum Test typically does not involve fasting or specific dietary restrictions. However, patients should follow any instructions provided by the healthcare provider to ensure accurate results.

Additional tests that may be ordered alongside the DHEA Serum Test include:

• 17-Hydroxyprogesterone (17-OHP) Test: To further evaluate congenital adrenal hyperplasia (CAH), especially in infants and children.

• Cortisol Test: To assess adrenal function and rule out conditions like Cushing's syndrome.

• Hormone panel: To evaluate the overall hormonal profile and detect imbalances.

• Chromosome analysis (karyotype): In cases of ambiguous genitalia, this test may be performed to assess chromosomal abnormalities.

• Dehydroepiandrosterone Serum Test
• DHEA Test

Congenital Adrenal Hyperplasia (CAH) is a genetic disorder that affects the adrenal glands, which are responsible for producing essential hormones. In individuals with CAH, there is a deficiency of enzymes needed for the synthesis of cortisol, aldosterone, and sometimes androgens (male sex hormones). As a result, there is an overproduction of androgens and, in some cases, a lack of cortisol and aldosterone. CAH is typically present from birth (congenital) and can manifest with varying degrees of severity. The excess androgens can cause ambiguous genitalia in females and rapid growth of male characteristics in both males and females. The condition may also lead to electrolyte imbalances due to the lack of aldosterone. Early diagnosis and management with hormone replacement therapy are crucial to address the hormonal imbalances and prevent complications. CAH is a lifelong condition, but with proper medical care, individuals with CAH can lead healthy lives.