Autoimmune Parkinsonian Profile

What is an Autoimmune Parkinsonian Profile Test?  

An autoimmune parkinsonian profile test is a specialised blood test that detects specific autoantibodies in your body. These are proteins made by your immune system that mistakenly attack your own nerve cells. This test helps identify whether your Parkinson's-like symptoms are caused by an autoimmune reaction rather than classic Parkinson's disease, which requires different treatment approaches. 

What does the Autoimmune Parkinsonian Profile Test measure? 

This comprehensive panel measures the presence and levels of specific autoantibodies that can cause neurological symptoms resembling Parkinson's disease: 

• Detects antibodies targeting nerve cell surface proteins (LGI1, CASPR2) 

• Identifies antibodies against proteins inside nerve cells 

• Measures immune responses that can damage brain and nervous system tissues 

• Helps distinguish autoimmune parkinsonism from other movement disorders 

Autoimmune Parkinsonian Profile Test: Who Needs It and Why It's Done 

What Symptoms May Call for an Autoimmune Parkinsonian Profile Test?  

Your doctor may recommend this test if you experience atypical symptoms that differ from classic Parkinson's disease: 

• Rapid onset of symptoms developing over weeks or months 

• Poor response to standard Parkinson's medications like Levodopa 

• Symmetrical symptoms affecting both sides of your body equally 

• Additional neurological signs like balance problems or muscle jerks 

• Early severe autonomic dysfunction affecting blood pressure or bladder control 

• Seizures or rapid cognitive decline 

• Movement symptoms appearing at a younger age 

Who should get an Autoimmune Parkinsonian Profile Test? 

This specialised test is recommended for specific patient groups who show concerning patterns: 

• Patients with atypical parkinsonian symptoms that don't fit classic Parkinson's disease 

• Individuals suspected of having paraneoplastic syndrome with rapid neurological changes 

• Younger patients developing parkinsonism with rapid progression 

• People whose symptoms don't improve with standard Parkinson's treatments 

• Patients showing unusual combinations of neurological symptoms 

Why is an Autoimmune Parkinsonian Profile Test done? 

This test is performed to determine the correct cause of your symptoms, as the diagnosis directly impacts your treatment plan and helps distinguish potentially treatable autoimmune conditions from progressive neurodegenerative diseases. 

Importance of an Autoimmune Parkinsonian Profile Test  

The autoimmune parkinsonian profile test holds significant clinical importance because it can completely change your diagnosis and treatment approach. Unlike classic Parkinson's disease, which requires dopamine replacement therapy, autoimmune parkinsonism responds to immunotherapy treatments like steroids or plasma exchange.  

Early identification allows doctors to start appropriate treatments that may halt or even reverse symptoms, offering hope for better outcomes than traditional neurodegenerative conditions. 

Autoimmune Parkinsonian Profile Test Booking & Reports – Metropolis Healthcare India 

How to Book an Autoimmune Parkinsonian Profile Test? 

1. Simple Online Booking 
   Booking can be done through the Metropolis Healthcare app or website. Select Autoimmune Parkinsonian Profile Test, choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab. 

1. Safe Home Sample Collection 
   Our trained phlebotomists ensure timely collection of your sample while strictly following all safety and hygiene protocols. 

1. Sample Tracking Updates 
   Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website. 

1. Accurate Laboratory Testing 
   Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results. 

1. Quick & Easy Reports 
   Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app. 

Is home sample collection for Autoimmune Parkinsonian Profile Test available near you?  

Yes, home blood sample collection is available for the autoimmune parkinsonian profile test. Our trained phlebotomists follow strict safety protocols while collecting your blood sample in the comfort of your home. With over 10,000 touchpoints across India, Metropolis Healthcare ensures reliable testing services reach you wherever you are, eliminating the stress of travelling to a lab when dealing with neurological symptoms. 

How Long Does It Take to Get an Autoimmune Parkinsonian Profile Test Report? 

Reports are usually available the next day: 5:00 PM once the sample reaches the pathology lab. 

Note: Reporting time may vary depending on your location. 

Where can I see or get Autoimmune Parkinsonian Profile Test results? 

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare app to view and download your reports. Additionally, test reports are sent via email or WhatsApp, and you also have the option to collect a physical copy directly from the lab. 

Interpreting Autoimmune Parkinsonian Profile Test Results 

What Your Autoimmune Parkinsonian Profile Test Results May Indicate 

The following table helps you understand what your test results mean for each antibody marker: 

Parameter	Normal Range	Positive Result Meaning	Negative Result Meaning
Anti-Hu (ANNA-1)	Negative/Not Detected	May indicate paraneoplastic encephalomyelitis or sensory neuropathy	No autoimmune reaction detected for this antibody
Anti-Ri (ANNA-2)	Negative/Not Detected	Associated with opsoclonus-myoclonus syndrome or brainstem encephalitis	No autoimmune reaction detected for this antibody
Anti-Yo (PCA-1)	Negative/Not Detected	Suggests paraneoplastic cerebellar degeneration	No autoimmune reaction detected for this antibody
Anti-Tr (DNER)	Negative/Not Detected	May indicate Hodgkin's lymphoma-associated cerebellar degeneration	No autoimmune reaction detected for this antibody
Anti-CV2 (CRMP5)	Negative/Not Detected	Associated with various paraneoplastic neurological syndromes	No autoimmune reaction detected for this antibody
Anti-PNMA2 (Ma2/Ta)	Negative/Not Detected	May suggest limbic encephalitis or brainstem dysfunction	No autoimmune reaction detected for this antibody
IgLON5	Negative/Not Detected	Associated with sleep disorders and movement abnormalities	No autoimmune reaction detected for this antibody
LGI1	Negative/Not Detected	May indicate limbic encephalitis with seizures or memory problems	No autoimmune reaction detected for this antibody
CASPR2	Negative/Not Detected	Associated with encephalitis, seizures, or peripheral nerve hyperexcitability	No autoimmune reaction detected for this antibody

Conditions that May Affect Autoimmune Parkinsonian Profile Test Accuracy 

Several factors can influence your autoimmune Parkinsonian profile test results and should be discussed with your doctor: 

• Certain medications, particularly immunosuppressive drugs like steroids or chemotherapy, can affect antibody levels 

• Recent immunotherapy treatments may temporarily alter autoantibody production 

• Dehydration can concentrate blood substances, potentially affecting readings 

• Active infections or recent vaccinations might influence immune system responses 

• Blood sample quality issues like haemolysis or improper storage can impact results 

• Timing of sample collection in relation to symptom onset may affect antibody detection 

How is an Autoimmune Parkinsonian Profile Test Done? 

The test involves a simple blood collection procedure performed by trained healthcare professionals: 

• A healthcare professional cleans the inside of your arm with an antiseptic solution 

• An elastic band is tied around your upper arm to make veins more visible 

• The blood sample is collected in a special gel vacutainer tube 

• The needle is removed and a cotton ball or bandage is applied to prevent bleeding 

• Your sample is labelled and sent to our NABL & CAP accredited laboratory for analysis 

• Advanced immunofluorescence assay and immunoblot techniques are used to detect specific antibodies 

How Should You Prepare for an Autoimmune Parkinsonian Profile Test? 

Preparing for this test is straightforward with minimal requirements: 

• No fasting required; you can eat and drink normally before the test 

• Continue your regular medications unless your doctor specifically advises otherwise 

• Stay well-hydrated by drinking adequate water before your appointment 

• Inform your healthcare provider about all medications, supplements, and recent treatments 

• Wear comfortable clothing with sleeves that can be easily rolled up for blood collection 

Diseases that an Autoimmune Parkinsonian Profile Test Can Help Detect 

This comprehensive test can help identify several serious neurological health conditions: 

• Autoimmune parkinsonism caused by immune system dysfunction 

• Paraneoplastic neurological syndromes associated with hidden cancers 

• Limbic encephalitis affecting memory and behaviour 

• Paraneoplastic cerebellar degeneration causing balance problems 

• Encephalomyelitis with brain and spinal cord inflammation 

• Opsoclonus-myoclonus syndrome with involuntary eye movements 

• Peripheral nerve hyperexcitability disorders 

Autoimmune Parkinsonian Profile Test/Packages that You Can Book With Metropolis Healthcare 

The following table shows comprehensive neurological testing options available to support your diagnosis: 

Test/Package Name	Purpose/Highlights
Autoimmune Encephalitis Panel Test	Detects antibodies causing brain inflammation and seizures
Anti-GAD-65 Paraneoplastic Syndrome Serum	Identifies specific antibodies linked to neurological symptoms and diabetes
Paraneoplastic Syndrome/Neuronal Antibody Profile Test	Comprehensive screening for cancer-related neurological disorders

Test/Package Name	Purpose/Highlights
Pre-Transplant Workup Panel	Comprehensive evaluation for organ transplant candidates
NextGen HRR Gene Panel	Advanced genetic testing for hereditary cancer risks
DNA Paternity 16 Markers	Paternity testing using 16 genetic markers