ALK Gene Rearrangement Test

This test identifies if there are any rearrangements in the ALK gene. These alterations can cause cells to grow uncontrollably, playing a significant role in non-small cell lung cancer (NSCLC) development. Detecting ALK gene rearrangements helps determine targeted treatment options for NSCLC patients.

This test is done primarily:

• To pinpoint specific genetic changes leading to NSCLC
• To guide targeted therapy decisions
• To assess the prognosis and progression of NSCLC

This test is typically recommended if you:

• Have been diagnosed with non-small cell lung cancer (NSCLC)
• Are considering targeted therapy for NSCLC
• Need to evaluate the effectiveness of NSCLC treatment

• Abnormal Results: Presence of ALK gene rearrangements may indicate a likelihood of NSCLC.
• Abnormal results necessitate further evaluation and consultation with your doctor for appropriate management and treatment.

During this test:

• Your doctor will require a tumour tissue sample typically from a previous biopsy.
• The tissue sample is processed using FISH (fluorescence in situ hybridization) to detect ALK gene rearrangements.
• It's a painless procedure, but you may experience slight discomfort during the biopsy.

Before undergoing the test:

• Ensure your tumour-containing tissue sample is fixed in 10% neutral buffered formalin and embedded in paraffin.
• Provide your clinical history along with any relevant reports to aid accurate interpretation.
• Ship the tissue sample at ambient temperature as per shipping guidelines.

Reach out to your healthcare provider for specific requirements.

Other tests that may be recommended alongside include:

• EGFR Mutation Testing: Identifies mutations in the EGFR gene linked to NSCLC.
• KRAS Mutation Testing: Detects mutations in the KRAS gene associated with different cancers.

NSCLC ALK FISH Test or Anaplastic Lymphoma Kinase Gene Rearrangement Test

Non-Small Cell Lung Carcinoma (NSCLC) is one of the most common types of lung cancer, characterized by uncontrolled cell growth in the lung tissues, affecting breathing and eventually, overall health. The mutating cells in this type of cancer are typically larger in size as compared to small cell lung cancer (SCLC). NSCLC is also usually less aggressive than SCLC.