MPN Comprehensive Panel

This test measures several genetic mutations and abnormalities in the blood, including BCR-ABL, JAK-2, Calreticulin Exon 9 Mutation, and MPL W515/S505 Mutation. These tests help identify specific changes in genes, chromosomes, or proteins that are associated with different types of myeloproliferative neoplasms (MPN).

This test is done to:

• Diagnose myeloproliferative neoplasms (MPN) such as chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF)
• Differentiate between types of MPN for appropriate treatment
• Monitor response to treatment and disease progression
• Assess the risk of developing complications

This test is recommended if you have:

• Symptoms of MPN such as fatigue, weakness, enlarged spleen, or abnormal blood counts
• Previously diagnosed MPN to assess disease progression or response to treatment
• Family history of MPN or known genetic risk factors for MPN

Abnormal results from the MPN Comprehensive Panel may indicate the presence of specific genetic mutations associated with myeloproliferative neoplasms (MPN) such as chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Further evaluation and consultation with a hematologist are necessary for accurate diagnosis and appropriate treatment.

• Abnormal BCR-ABL by FISH result may indicate chronic myeloid leukemia (CML).
• Abnormal JAK-2 mutations may suggest polycythemia vera (PV) or essential thrombocythemia (ET).
• Abnormal CALR Exon 9 Mutation or MPL W515/S505 Mutation result may indicate primary myelofibrosis (PMF).

During the test:

• A sample of your blood is collected
• The blood sample is sent to the laboratory for testing
• The laboratory uses techniques like FISH, real-time PCR, and sequencing to analyse the genetic mutations and abnormalities associated with MPN

Before the test:

• No fasting or special diet is required
• Inform your doctor about any medications you are taking as they may interfere with the test results
• Follow any additional instructions given by your doctor

• Complete Blood Count (CBC): To evaluate red blood cells, white blood cells, and platelets
• Bone marrow biopsy: To further assess the presence and extent of myeloproliferative neoplasms (MPN)
• Cytogenetic analysis: To detect chromosomal abnormalities
• Molecular testing: For specific gene mutations associated with MPN

Myeloproliferative Neoplasm Panel or MPN Panel

Myeloproliferative neoplasms (MPN) are a group of rare blood disorders characterised by the overproduction of certain types of blood cells. Common types of MPN include chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF).