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Lupus Anticoagulants LAC Profile Test
Also known as: Lupus Anticoagulant (LAC) Profile, Citrated Plasma
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
NABL & CAP Accredited Labs
Accurate & Quality Test Reports
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Lupus Anticoagulant (LAC) Profile, Citrated Plasma Details in Brief
| Also Known As | LAC Test, Lupus Anticoagulant Profile, Antiphospholipid Antibody Screening |
|---|---|
| Purpose | To detect lupus anticoagulant antibodies that may increase risk of abnormal blood clots, miscarriages, or autoimmune disease complications |
| Preparation | Avoid taking anticoagulant medications (like heparin or warfarin) before the test, as advised by your doctor |
| Fasting | Not required |
| Reporting Time | After 6 hours |
| Cost | 2,400 |
What is a Lupus Anticoagulant (LAC) Test?
The Lupus Anticoagulant (LAC) Test is a specialised blood test used to detect abnormal antibodies called lupus anticoagulants that interfere with normal blood clotting. Despite their name, these antibodies are not directly related to lupus alone—they can occur in healthy individuals or those with Antiphospholipid Syndrome (APS), an autoimmune condition that increases the risk of abnormal blood clots and recurrent miscarriages.
Doctors recommend this test if you have a history of unexplained thrombosis (clots), recurrent pregnancy loss, or suspected autoimmune disorders such as Systemic Lupus Erythematosus (SLE). The test is performed on a citrated plasma sample drawn from your arm.
What Does a Lupus Anticoagulant (LAC) Test Measure?
This test evaluates how long it takes your blood to clot by performing a set of coagulation assays:
- aPTT (Activated Partial Thromboplastin Time): Detects prolonged clotting due to abnormal antibodies.
- aPTT Mixing Studies: Helps determine whether a prolonged clotting time is due to an inhibitor (like LAC) or a factor deficiency.
- DRVVT (Dilute Russell Viper Venom Test): Confirms the presence of lupus anticoagulant by comparing clotting times before and after phospholipid neutralisation.
- Normalised Ratio: Compares your test values with control plasma to confirm antibody activity.
Together, these help identify whether lupus anticoagulant antibodies are interfering with your blood clotting system.
Lupus Anticoagulant (LAC) Test: Who Needs It and Why It’s Done
What Symptoms May Call for a LAC Test?
Your doctor may advise this test if you have:
- Unexplained blood clots in veins or arteries (deep vein thrombosis, stroke, or pulmonary embolism)
- Recurrent miscarriages or stillbirths
- Prolonged clotting time in routine coagulation tests (like aPTT)
- Autoimmune disease symptoms, such as fatigue, rashes, or joint pain
- History of Antiphospholipid Syndrome (APS) or Systemic Lupus Erythematosus (SLE)
Who Should Get a LAC Test?
You may need this test if you:
- Have experienced unexplained venous or arterial thrombosis
- Have had recurrent pregnancy loss (especially in the first or second trimester)
- Are being investigated for APS or lupus
- Show prolonged clotting in screening tests without clear cause
- Are on long-term anticoagulant therapy and need monitoring
Why is a LAC Test Done?
The test helps identify lupus anticoagulant antibodies, which increase the risk of thrombosis and pregnancy complications, and guide appropriate treatment strategies to prevent recurrence.
Importance of a Lupus Anticoagulant (LAC) Test
Detecting lupus anticoagulant early helps prevent serious complications like stroke, deep vein thrombosis, or recurrent miscarriage. It is a key diagnostic tool for Antiphospholipid Syndrome (APS) and helps doctors tailor anticoagulant therapy or pregnancy management plans. Persistent positive results across two tests 12 weeks apart confirm the presence of lupus anticoagulant.
Lupus Anticoagulant (LAC) Test Booking & Reports – Metropolis Healthcare
How to Book the Lupus Anticoagulant (LAC) Test and Get Your Reports?
- Simple Online Booking
You can book the Lupus Anticoagulant (LAC) Test through the Metropolis Healthcare website or app. Choose your preferred slot for home collection or visit your nearest Metropolis lab. - Safe Home Sample Collection
Our trained phlebotomists ensure hygienic and comfortable blood collection at your home. - Sample Tracking Updates
Track your sample status in real-time through the Metropolis Healthcare website. - Accurate Laboratory Testing
Testing is performed at NABL & CAP accredited laboratories using advanced coagulation analysis methods. - Quick & Easy Reports
Get your reports promptly via email, WhatsApp, or download them directly from the Metropolis Healthcare app or website.
Is Home Sample Collection for Lupus Anticoagulant (LAC) Test Available Near You?
Yes. Metropolis Healthcare offers home sample collection for the LAC test. Our team follows strict safety standards to ensure comfort and precision, making it convenient for those who cannot visit the lab.
How Long Does It Take to Get a Lupus Anticoagulant (LAC) Test Report?
Reports are usually available within 6 hours once your sample reaches the lab.
Note: Reporting time and cost may vary depending on your location.
Where Can I See or Get Lupus Anticoagulant (LAC) Test Results?
You can view and download your reports using the Metropolis Healthcare App or website. Reports are also sent via email or WhatsApp, and you can collect a printed copy from your nearest lab if required.
Interpreting Lupus Anticoagulant (LAC) Test Results
What Your LAC Test Results May Indicate
| Parameter | Normal Range | High/Abnormal Values May Indicate | Normal Values May Indicate |
|---|---|---|---|
| aPTT (Test) | 35.08–43.81 sec | Prolonged clotting time suggests lupus anticoagulant or inhibitor | Normal coagulation function |
| DRVV Screen Ratio | 0.85–1.20 | Ratio >1.2 indicates presence of lupus anticoagulant | Ratio within range suggests LAC absent |
| Lupus Anticoagulant | Absent | Presence indicates autoimmune activity or APS | No abnormal antibodies detected |
Understanding Abnormal LAC Results by Parameter
| Result Pattern | Interpretation |
|---|---|
| Abnormal aPTT and abnormal DRVV (ratio >1.2) | Lupus Anticoagulant Present – confirms antiphospholipid activity |
| Abnormal aPTT corrected on mixing study | Factor Deficiency rather than inhibitor |
| Abnormal aPTT not corrected, abnormal DRVV | Inhibitor or LAC likely |
| Normal results on all parameters | LAC Absent – no evidence of lupus anticoagulant antibodies |
How Should You Prepare for a Lupus Anticoagulant (LAC) Test?
Preparation is important for accurate results:
- Fasting not required: You may eat and drink normally before your test.
- Medication review: Inform your doctor if you’re taking anticoagulants (like heparin or warfarin) as they may affect test results.
- Avoid recent transfusions: Wait at least 2–3 weeks after blood transfusion before testing.
- Hydration: Drink water to make sample collection easier.
- Avoid strenuous activity: Heavy exercise before testing may influence coagulation markers.
How Is a Lupus Anticoagulant (LAC) Test Done? (Step-by-Step Procedure)
The test involves a standard blood collection procedure:
- Preparation: A tourniquet is applied to your upper arm to locate a vein.
- Cleaning: The area is cleaned using antiseptic.
- Sample Collection: 1 ml of citrated plasma is collected in a 3.2% sodium citrate vacutainer.
- Freezing: The sample is processed and stored in frozen condition for accurate testing.
- Analysis: Coagulation assays (aPTT, DRVV screen, DRVV confirm) are performed using advanced automated analysers.
Conditions That May Affect Lupus Anticoagulant (LAC) Test Accuracy
Certain factors can influence test accuracy:
- Heparin or anticoagulant use: May cause false positive or negative results.
- Acute infections or inflammation: Can temporarily increase lupus anticoagulant activity.
- High Factor VIII levels: May lead to false negative results.
- Haemolysed or clotted samples: Can invalidate results.
- Recent thrombotic events: Testing should be delayed until the acute phase resolves.
Diseases That a Lupus Anticoagulant (LAC) Test Can Help Detect
This test helps identify and monitor:
- Antiphospholipid Syndrome (APS)
- Systemic Lupus Erythematosus (SLE)
- Recurrent Pregnancy Loss
- Deep Vein Thrombosis (DVT)
- Stroke or Arterial Thrombosis
- Autoimmune Disorders with Thrombotic Risk
- Unexplained Coagulation Abnormalities
Lupus Anticoagulant (LAC) Test Price in Different Cities
The cost of a Lupus Anticoagulant (LAC) Test may vary depending on your location. Here's a table showing the approximate price range for the Lupus Anticoagulant (LAC) Test at Metropolis Healthcare in major Indian cities:
|
City |
Approximate Cost (INR) |
|
₹ 2300 to ₹ 2500 |
|
|
₹ 2300 to ₹ 2500 |
|
|
₹ 2300 to ₹ 2500 |
|
|
₹ 2300 to ₹ 2500 |
The Lupus Anticoagulant (LAC) Test cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive Lupus Anticoagulant (LAC) Test prices across major cities in India.
References
- Pengo V., Tripodi A., Reber G., et al. (2009). Update of the guidelines for lupus anticoagulant detection. Journal of Thrombosis and Haemostasis, 7(10), 1737–1740. PMID: 19624461
- Devreese K.M.J., Pierangeli S.S., de Laat B., et al. (2014). Testing for the lupus anticoagulant: An update of the ISTH guidelines. Journal of Thrombosis and Haemostasis, 12(11), 1908–1915. PMID: 25252706
- Ruiz-Irastorza G., Crowther M., Branch W., Khamashta M.A. (2010). Antiphospholipid syndrome. The Lancet, 376(9751), 1498–1509. PMID: 20822808
- Miyakis S., Lockshin M.D., Atsumi T., et al. (2006). International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. Journal of Thrombosis and Haemostasis, 4(2), 295–306. PMID: 16420554
- Pierangeli S.S., Harris E.N. (2008). Clinical laboratory testing for the antiphospholipid syndrome. Clinical & Diagnostic Laboratory Immunology, 15(1), 10–17. PMID: 17989387
Lupus Anticoagulant (LAC) Profile, Citrated Plasma Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Lupus Anticoagulant (LAC) Profile, Citrated Plasma with a clear pricing structure.
The Lupus Anticoagulant (LAC) Profile, Citrated Plasma Price in Mumbai is ₹ 2,400 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
A positive result indicates the presence of lupus anticoagulant antibodies, suggesting increased risk of blood clots or pregnancy loss.
No fasting is required for this test.
Yes. Anticoagulants like heparin or warfarin can interfere with results. Inform your doctor about all medications.
A blood sample is collected and tested using clotting assays such as aPTT and DRVV to detect lupus anticoagulant.
Not necessarily. While lupus anticoagulant can occur in lupus, it may also appear in APS or other autoimmune conditions.
The normal DRVV screen ratio ranges from 0.85 to 1.20. A value above 1.2 suggests lupus anticoagulant presence.
If positive, it should be repeated after 12 weeks to confirm persistent lupus anticoagulant.
Risks are minimal and include slight bruising or discomfort at the puncture site.
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We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
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