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Calprotectin in Guwahati

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The calprotectin measures the amount of protein calprotectin in your stool

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    To detect inflammation in the intestines; to distinguish between inflammatory bowel disease (IBD) and non-inflammatory bowel conditions; to monitor for a condition called “inflammatory bowel disease (IBD)”.

Your doctor may recommend this test for you when you show symptoms like:

  1. Bloody or watery diarrhoea
  2. Abdominal cramps
  3. Fever lasting for than few days

Calprotectin is a protein released by the blood cells of the body’s defence system-WBCs, especially neutrophils. When there is an inflammation in the body, especially the gastrointestinal tract, the neutrophils get transported to the concerned site of action and release calprotectin, which then gets excreted in the faeces. This test assesses the presence of any inflammatory reactions taking place in the intestine. 

Reference Values

  • 0-110 ug/g faeces: Normal faecal calprotectin
  • 110-1800 ug/g faeces: Raised faecal calprotectin may indicate IBD

Interpretations

  • An elevated calprotectin level is a person's stool indicates that inflammation is probably present within the intestines but doesn't indicate either its location or cause. Generally, the degree of elevation is related to the severity of the inflammation.
  • A low calprotectin usually indicates the presence of non-inflammatory conditions that are producing overlapping symptoms as that of inflammatory disorders. Indications of these include viral infections within the digestive tract and irritable bowel syndrome (IBS). Unlike IBD, IBS doesn't cause an inflammation. Rather, it causes cramp-like stomach pains and spasms with bouts of diarrhoea and/or constipation. In people with low calprotectin results, an endoscopy of the digestive tract.
  • A moderate calprotectin level may indicate the presence of inflammation or exacerbation of the already existing inflammatory conditions. A repeated calprotectin test which reproduces the result as seen in previous test mandate further evaluation with confirmatory tests like endoscopy.

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Calprotectin

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