Chimerism (Pre-transplant), STR Analysis (Donor and Recipient)

Chimerism (Pre-transplant) measures the levels of donor and recipient DNA in a patient's blood or bone marrow. This is crucial to evaluate the engraftment status and effectiveness of a transplant, as it shows how well the new cells are growing in the recipient's body.

This test is done:

• To assess the success of a bone marrow transplant
• To monitor the engraftment of donor cells
• To detect and manage graft-versus-host disease
• To guide treatment decisions
• To evaluate the need for additional therapies post-transplant

This test is usually recommended for individuals who have undergone a bone marrow transplant. It is suitable for:

• Patients receiving an allogeneic bone marrow transplant
• Those at risk for graft rejection or graft-versus-host disease
• Individuals needing to monitor treatment response post-transplant

Abnormal results may indicate:

• Insufficient engraftment
• Increased risk of graft failure
• Development of graft-versus-host disease
• Need for additional treatment or intervention.

Discuss abnormal results with your doctor promptly.

During this test:

• Blood samples are collected via a simple venipuncture procedure.
• The samples are analysed using PCR fragment analysis.
• Results are typically available within a week.

Before the test:

• Follow any fasting or dietary restrictions advised by your doctor
• Inform your healthcare provider about any medications you are taking, as some may interfere with test results
• Ensure you are well-hydrated before blood collection

Tests often done alongside Chimerism (Pre-transplant) include:

• HLA typing: Identifies human leukocyte antigen matches
• Graft-versus-host disease tests: Check for immune system complications post-transplant
• Blood counts: Monitor cell levels after transplantation
• Bone Marrow Aspiration: Assess bone marrow function and health
• Donor Lymphocyte Infusion (DLI): Boost immune response post-transplant
• CD34 Cell Enumeration: Evaluate stem cell counts post-transplant

Chimerism analysis or Donor and recipient DNA testing

Bone marrow transplantation is a procedure used to replace damaged or diseased bone marrow with healthy stem cells from a compatible donor. It is commonly performed to treat conditions like leukaemia, lymphoma, and certain genetic disorders.