CeliaCheck Profile

The CeliaCheck Profile is a non-invasive blood test designed to detect celiac disease, an autoimmune disorder triggered by gluten consumption in genetically susceptible individuals. When someone with celiac disease ingests gluten, their immune system produces antibodies that attack the small intestine, leading to inflammation and damage. The CeliaCheck Profile measures the levels of these specific antibodies, namely tissue transglutaminase IgA (tTG IgA), deamidated gliadin peptide IgG (DGP IgG), and total IgA. By evaluating these markers, doctors can accurately diagnose celiac disease and monitor treatment response.

Preparation For CeliaCheck Profile

Here are a few key points to keep in mind for CeliaCheck Profile preparation:

• Continue consuming a gluten-containing diet before the test. Removing gluten can decrease antibody levels and lead to false-negative results.
• Inform your doctor about any medications or supplements you're taking, as some may interfere with the test results.
• Fasting is generally not required, but always follow the specific instructions provided by your doctor.
• For children, ensure they have been exposed to gluten for several months before testing to allow antibodies to reach detectable levels.

Procedure of the CeliaCheck Profile

The CeliaCheck Profile procedure involves a standard blood draw, typically from a vein in your arm. Here's what you can expect:

• A healthcare professional will clean the skin around the injection site with an antiseptic.
• A tourniquet will be applied to your upper arm to make the veins more visible and accessible.
• A needle will be inserted into the vein, and blood will be collected into one or more vials.
• Once sufficient blood is drawn, the needle will be removed, and a bandage will be applied to the site.

The collected blood sample is then sent to a laboratory for analysis. You can usually resume normal activities immediately after the blood draw, but avoid strenuous exercise or heavy lifting for a few hours. CeliaCheck Profile results are typically available within a few days to a week.

Symptoms That May Call For CeliaCheck Profile

Several symptoms may prompt your doctor to recommend the CeliaCheck Profile:

• Chronic diarrhoea or constipation
• Abdominal pain, bloating, or gas
• Unexplained weight loss or failure to gain weight (especially in children)
• Fatigue or weakness
• Anaemia resistant to iron supplementation
• Skin rashes, such as dermatitis herpetiformis
• Mouth ulcers or dental enamel defects
• Osteoporosis or bone pain
• Neurological symptoms, such as peripheral neuropathy or ataxia

Remember, celiac disease can present with a wide range of symptoms, and some individuals may be asymptomatic. If you have a family history of celiac disease or belong to a high-risk group, discuss the benefits of screening with your doctor.

CeliaCheck Profile Interpretation

Interpreting the CeliaCheck Profile report requires a comprehensive evaluation by a doctor. Here are some general guidelines:

• Positive tTG IgA and/or DGP IgG: Elevated levels of these antibodies strongly suggest celiac disease. Your doctor may recommend a small intestine biopsy to confirm the diagnosis.
• Low total IgA: This indicates possible IgA deficiency, making DGP IgG a more relevant marker. Additional testing may be necessary.
• Negative results for all markers: celiac disease is less likely, but further investigation may be warranted if symptoms persist or if there is a strong clinical suspicion.

It's essential to interpret the CeliaCheck Profile results in the context of your overall health, symptoms, and medical history. Your doctor will guide you through the next steps based on your individual circumstances.

Factors that can affect the CeliaCheck Profile Result

Several factors can influence the accuracy of the CeliaCheck Profile result:

• Gluten-free diet: Consuming a gluten-free diet before testing can lower antibody levels and lead to false-negative results. It's crucial to continue eating gluten-containing foods until testing is complete.
• IgA deficiency: Individuals with selective IgA deficiency may have false-negative tTG IgA results. In such cases, DGP IgG becomes a more reliable marker.
• Age: Children under 3 years old may not produce sufficient antibodies for accurate detection. Retesting at an older age might be necessary.
• Immunosuppressive medications: Certain medications that suppress the immune system can affect antibody production and lead to false-negative results.
• Recent infections or vaccinations: These can temporarily elevate antibody levels, leading to false-positive results.

Discuss any concerns or factors that may impact your test results with your doctor to ensure accurate interpretation.