Almost Millions cases of COVID-19 have been confirmed worldwide, resulting in large number of deaths. For such a high volume of patients presenting at hospitals and other health care centers, accurate diagnosis and efficient markers for disease severity, therapeutic response, and disease outcome are key. Laboratory test biomarkers can play a useful role here.
These tests are required for monitoring the patient’s health status throughout the course of the disease and are categorised day wise as the illness progresses. These tests are required whether the patient is admitted to hospital or under home care .
High fever, chills , cough, shortness of breath ,diarrhoea, fatigue ,pneumonia . Complications such as heart failure, myocardial infarction, respiratory failure , thromboembolic events - (stroke and limb ischaemia), acute kidney injury , inflammatory syndrome .
Disease can present as acute viral pneumonia, acute lung damage , acute respiratory distress syndrome . The primary infection could be followed by hyperactive immune reaction which seem to underlie the severe manifestations of the disease
Compared to non-ICU patients, ICU patients had higher plasma levels of IL-6, D-dimer and platelets.
Lymphopenia, neutrophilia, elevated serum ALT and AST levels, elevated LDH, CRP, and ferritin levels have been associated with greater disease severity and hospitalization in COVID-19 patients
Elevated ALT, AST, and creatinine seen in severe cases suggests that COVID-19 carries an increased risk of impaired liver and kidney function
Lymphopenia was more common in ICU patients than non-ICU patients
Significantly more patients in the severe group experienced higher CRP and IL-6 levels vs non-severe.
Cardiac troponin, Myoglobin, CRP and IL-6 significantly increased in cases with mortality
Increased CRP and decreased albumin strongly correlated with disease progression
LDH, NC, CRP and platelet count were higher in refractory vs general patients. Refractory patients had more cases of lung abnormalities, suggesting these biomarkers correlate with development of disease
C-reactive protein (CRP), lactate dehydrogenase (LDH), high-sensitivity troponin (hs-Tn), N-terminal pro–B-type natriuretic peptide (NT-proBNP), and D-dimer improve prognostication in patients hospitalized with coronavirus disease 2019 (COVID-19)
The levels of biomarkers may change according to severity of COVID-19 infection. This can be used as an adjunct in clinical practice to guide treatment and admission to ICU. By doing so, it may improve prognosis and minimise the mortality rates
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Metropolis has a team of 200 senior pathologists and over 2000 technicians delivering diagnostic solutions in the areas of routine, semi specialty and super specialty domains like Oncology, Neurology, Gynaecology, Nephrology and many more.
We offer a comprehensive range of 4000+ clinical laboratory tests and profiles, which are used for prediction, early detection, diagnostic screening, confirmation and/or monitoring of the disease.
