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TTG IgA Test - Antibody
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
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TTG IgA Test Overview
Celiac disease is an autoimmune disorder characterized by an inappropriate immune response to gluten, a protein found in wheat, and related dietary proteins in rye and barley.
The TTG IgA test, also known as the anti-TTG test, is a blood test used to diagnose and monitor celiac disease, an autoimmune disorder triggered by the ingestion of gluten, a protein found in wheat, rye, and barley. This test detects the presence of TTG antibodies, specifically of the IgA class, which are produced by the immune system in response to gluten. The TTG IgA test is considered the most sensitive and specific blood test for celiac disease, particularly for individuals over the age of 2 years.
Celiac disease is a chronic condition that damages the small intestine, leading to malabsorption of nutrients. When individuals with celiac disease consume gluten, their immune system responds by producing antibodies that attack the small intestine, causing inflammation and damage to the intestinal lining. The TTG IgA test helps identify this immune response and aids in the diagnosis of celiac disease, allowing for appropriate management through a gluten-free diet.
Reasons for Undergoing the TTG IgA Test
There are several reasons why a doctor may recommend the TTG IgA test:
- Diagnosis of Celiac Disease: The test is often ordered for individuals who exhibit symptoms suggestive of celiac disease, such as abdominal pain, diarrhea, weight loss, and fatigue.
- Monitoring Treatment: For patients already diagnosed with celiac disease, the TTG IgA test helps evaluate the effectiveness of a gluten-free diet in managing the condition.
- Risk Assessment: Individuals with conditions that increase the risk of celiac disease, such as type 1 diabetes or thyroid disease, may undergo the TTG IgA test as part of their screening process.
- Family Screening: Family members of individuals diagnosed with celiac disease may be advised to take the TTG IgA test, as there is a genetic component to the disease.
List of Parameters Considered During the TTG IgA Test
The TTG IgA test focuses on measuring specific antibodies in the blood:
- Anti-tTG IgA Antibodies: These antibodies are produced by the immune system in response to gluten. Elevated levels of these antibodies indicate an immune response to gluten, which is characteristic of celiac disease.
- Negative: Typically <4.0 U/mL or <20 (varies by lab), indicating no significant immune response to gluten.
- Weak Positive: Between 4.0-10.0 U/mL or 20-30 (varies by lab), suggesting a possible immune response.
- Positive: >10.0 U/mL or >30 (varies by lab), indicating a strong immune response and likely diagnosis of celiac disease.
TTG IgA Test Preparation
To ensure accurate results, certain preparations are necessary before undergoing the TTG IgA test:
- Gluten Consumption: It is crucial to continue eating a gluten-containing diet until the test is performed. Avoiding gluten can lead to false-negative results.
- Inform Your Doctor: Notify your doctor about any medications you are taking, as some may affect the test results.
- No Fasting Required: Fasting is not necessary for this test.
- Blood Sample: The test involves a blood sample drawn from a vein, which is then tested for anti-tTG IgA antibodies.
TTG IgA Test Results & Interpretation
The results of the TTG IgA test are interpreted based on the levels of anti-tTG IgA antibodies in the blood:
- Negative: It indicates that celiac disease is unlikely, especially if the patient has been consuming gluten.
- Weak Positive: It suggests a possible immune response to gluten, but further testing, such as an intestinal biopsy, may be necessary to confirm the diagnosis.
- Positive: Strongly indicates celiac disease, and an intestinal biopsy may be recommended to confirm the diagnosis and assess the extent of intestinal damage.
Home Collection for TTG IgA Test
Metropolis Healthcare offers a convenient home sample collection service for the TTG IgA test. A trained phlebotomist will visit your doorstep to collect the blood sample, ensuring comfort and safety while maintaining high standards of sample handling and testing accuracy. This service allows individuals to undergo the test without the need to visit a diagnostic center, making healthcare more accessible. With timely and reliable results, Metropolis Healthcare is committed to providing quality diagnostic solutions conveniently at home, empowering individuals to take proactive steps in managing their health.
TTG IgA Test - Antibody Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the TTG IgA Test - Antibody with a clear pricing structure.
The TTG IgA Test - Antibody Price in Kolkata is ₹ 1,600 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
Test helps in diagnosis of celiac disease and to evaluate the effectiveness of a gluten-free diet
Test is done on patient suffering from suspected Celiac disease
Celiac disease antibody tests help diagnose and monitor the disease and a few other gluten-sensitive conditions. These tests detect autoantibodies in the blood that the body produces as part of the immune response. Tissue transglutaminase antibody (tTG), IgA class — the primary test ordered to screen for celiac disease. It is the most sensitive and specific blood test for celiac disease and is the single test preferred by the American College of Gastroenterology and the American Gastroenterology Association for the detection of celiac disease in those over the age of 2 years. If the test is positive, it can also be used to monitor the condition and to help evaluate the effectiveness of treatment.
The TTG IgA Test is a blood test that measures anti-TTG IgA antibodies to diagnose and monitor coeliac disease, an autoimmune disorder triggered by the ingestion of gluten.
Yes, home sample collection for the TTG IgA Test may be available through certain diagnostic centres, like Metropolis Healthcare. Check with local healthcare providers or labs for this service.
The TTG IgA Test is used to diagnose coeliac disease, monitor treatment efficacy, assess risk in related conditions, and screen family members of individuals with coeliac disease.
The normal range of the TTG IgA Test varies by lab but is typically: Negative: <4.0 U/mL or <20; weak positive: 4.0-10.0 U/mL or 20-30; positive: >10.0 U/mL or >30.
Anyone suspected of having coeliac disease, those with risk factors like type 1 diabetes or thyroid disease, and family members of individuals with coeliac disease are eligible for the TTG IgA Test.
The TTG IgA Test is highly sensitive and specific for diagnosing coeliac disease, helps in monitoring treatment, and is a non-invasive test that can be performed easily.
The frequency of TTG IgA Testing depends on individual needs, such as monitoring treatment efficacy or assessing risk over time. Consult your healthcare provider for personalised recommendations.
There is no specific time requirement for the TTG IgA Test; however, it is essential to continue eating gluten until the test is performed to ensure accurate results.
No, fasting is not required for the TTG IgA Test. You can eat and drink normally before the test.
Before getting the TTG IgA Test, inform your doctor about any medications you are taking, and ensure you are consuming a gluten-containing diet to avoid false-negative results.
The primary parameter included in the TTG IgA Test is the level of anti-tissue transglutaminase IgA antibodies in the blood, which indicates an immune response to gluten.
The TTG IgA Test involves drawing a blood sample from a vein, which is then sent to a laboratory for analysis to measure the levels of anti-TTG IgA antibodies.
The TTG IgA Test should be done when an individual exhibits symptoms of coeliac disease, has risk factors, or needs to monitor the effectiveness of a gluten-free diet.
The TTG IgA Test becomes positive when the levels of anti-TTG IgA antibodies in the blood are elevated, typically >10.0 U/mL or >30, indicating a strong immune response to gluten.
The TTG IgA Test itself takes only a few minutes, as it involves drawing a blood sample. However, the analysis of the sample may take a few days.
The turnaround time for TTG IgA Test reports varies from lab to lab, but results are usually available within a week based on the day/time when the sample is collected and processed.
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