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Thyroglobulin Antibody ATA Serum - TG Test

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Thyroglobulin - TG Test Overview

Thyroglobulin (TG) is a protein formed in thyroid gland and serves as a substrate for synthesis of thyroid hormones. 
Thyroglobulin antibodies (ATA) thus prevent formation of thyroid hormone leading to hypothyroidism. These antibodies are hallmark of Hashimoto thyroiditis but can be seen in Graves' disease also. 

Thyroglobulin Antibody ATA Serum is a laboratory test. It is used to measure the level of thyroglobulin antibodies in the body. The body's immune system comes across an antigen related to the thyroid gland. Then it makes these antibodies.

The level of thyroglobulin antibodies in the serum can show if someone has autoimmune thyroid disease. The doctor usually orders the test when a person has signs and symptoms of autoimmune thyroid disease. A doctor may also order the test if the TSH level is too high or too low or to check on how well thyroid therapy works.

What is Thyroglobulin Antibody ATA Serum?

Thyroglobulin Antibody ATA serum, or ATA, is a type of antibody made by the body in response to the presence of thyroglobulin. Thyroglobulin is a protein found in the thyroid. ATA is a sign of thyroid autoimmunity. It occurs when the immune system attacks the thyroid gland instead of the body's cells. When the serum has a lot of ATA, it can mean that the body is making autoantibodies that attack the thyroid gland. This is called an autoimmune disorder.

It is important to note that ATA levels can vary from person to person. They may not always indicate an autoimmune disorder. Testing for ATA is important for diagnosing and monitoring autoimmune thyroid disorders.

What does a Thyroglobulin Antibody ATA Serum test do?

Thyroglobulin Antibody ATA Serum Test is a blood test used to detect antibodies in the body's immune system. It is used to diagnose Hashimoto's, Grave's, and other autoimmune thyroid diseases.

• This test measures the amount of thyroglobulin antibody in a patient’s serum.

• A positive result indicates an autoimmune thyroid disease such as Hashimoto’s or Graves.

• The test is used to see how well the treatment works. It is also to ensure that the thyroid hormone levels are right.

• It can also be used to diagnose an autoimmune thyroid disease in a patient who is not yet showing any symptoms or has other medical conditions that could interfere with the accuracy of the test.

Written by: Dr Vishal Wadhwa, M.D, D.N.B Microbiology, Medical Affairs

Reasons for Undergoing the Anti Thyroglobulin Antibody

The thyroglobulin antibody ATA serum - TG test is a crucial diagnostic tool for managing thyroid health, particularly in patients with thyroid cancer or autoimmune thyroid disorders. Some key reasons for undergoing this test include:

  • Postoperative evaluation: Following surgical treatment for thyroid cancer, the anti-thyroglobulin test helps assess the success of the procedure in removing all thyroid cells, including cancerous ones.
  • Monitoring for recurrence: The test is used to monitor patients for the recurrence of thyroid cancer, especially papillary and follicular thyroid carcinomas, enabling early detection and timely intervention.
  • Prognosis: Anti-thyroglobulin antibody levels can provide valuable insights into survival rates and the likelihood of cancer recurrence, aiding in long-term follow-up and management of thyroid cancer patients.
  • Diagnosis and management of autoimmune thyroid diseases: The anti-thyroglobulin antibody test is essential for diagnosing and managing autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease, where the immune system attacks the thyroid gland.

List of Parameters Considered During the Anti Thyroglobulin Antibody

The thyroglobulin antibody ATA serum - TG test measures two key parameters to evaluate thyroid health and monitor thyroid cancer:

  • Thyroglobulin (Tg) Levels: This parameter quantifies the amount of thyroglobulin protein in the blood, which is produced by the thyroid gland. Elevated Tg levels after thyroid cancer treatment may signify residual or recurrent disease. In athyrotic individuals on suppressive therapy, normal levels are typically very low (less than 0.1-0.2 ng/mL).
  • Anti-Thyroglobulin Antibodies (TgAb) Levels: This measures the presence and concentration of antibodies against thyroglobulin. These antibodies can interfere with Tg measurements and are often present in autoimmune thyroid diseases. Positive TgAb levels can indicate autoimmune thyroid disease or lead to false-low Tg measurements in immunometric assays.

Home Collection for Anti Thyroglobulin Antibody Near You

Metropolis Healthcare offers a convenient and hassle-free home collection service for the thyroglobulin antibody ATA serum - TG test. Our trained phlebotomists will visit your doorstep to collect blood samples, ensuring your comfort and safety. We maintain the highest standards of sample handling and testing accuracy, so you can trust the reliability of your results.

With Metropolis Healthcare, you can access quality diagnostic solutions from the comfort of your home, without compromising on the quality of care. Our commitment to making healthcare accessible means that you can receive timely and accurate test results, empowering you to take control of your thyroid health.

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Thyroglobulin Antibody ATA Serum - TG Test Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the Thyroglobulin Antibody ATA Serum - TG Test with a clear pricing structure.

The Thyroglobulin Antibody ATA Serum - TG Test Price in Mumbai is ₹ 1,550 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

TG test is used to aid diagnosis of autoimmune disorder as cause of hypothyroidism

This test is typically done to help diagnose autoimmune thyroid disease, such as Hashimoto’s thyroiditis.

This test measures the level of ATA antibody in blood

The Thyroglobulin Antibody ATA Serum measures the levels of autoantibodies. These can attack the thyroid. They can cause inflammation.

TG test requires a blood sample. A tourniquet (elastic) band is placed tightly on the upper arm. The patient is then asked to make a fist. This helps in the build-up of blood filling the veins. The skin is disinfected before needle insertion and the blood sample is collected in vacutainer.

A blood sample will be taken. It will be sent to the laboratory for analysis during the test.

Normal levels : no thyroid antibodies were found. This means that symptoms of hypothyroidism are probably not caused by deficiency of ATA.
High values: suggestive of  Hashimoto thyroiditis; these antibodies can also be seen in Grave's disease

If the results are present, this indicates that the patient has an autoimmune thyroid condition. If the results are absent, this indicates that the patient does not have an autoimmune thyroid condition.

You can prepare for this test by avoiding taking blood thinners or biotin supplements and fasting for 8 hours before the test.

Normal Thyroglobulin Antibody ATA Serum levels should be 0-1.

Thyroglobulin Antibody ATA Serum is a test. It measures the level of autoantibodies in the blood. These can attack the thyroid and cause inflammation.

One should opt for this test if they have any signs or symptoms of the below-mentioned conditions:

• Individuals at risk of developing thyroid disease.

• Those with a family history of thyroid disease, frequently exposed to radiation, or with a weakened immune system

• People with weight changes, trouble sleeping, fatigue, irritability, or trouble keeping their body temperature in check

• Those diagnosed with an autoimmune disorder.

• Women who are pregnant. This is to determine if they are at risk for developing thyroid disease during their pregnancy.

Doctors advise the Thyroglobulin Antibody ATA Serum Test for people with lifestyle issues such as:

  • High cholesterol
  • Hypertension
  • Obesity
  • Diabetes
  • Fatigue
  • Weight gain

Along with this, doctors may order other tests to diagnose thyroid conditions further and keep an eye on them, such as:

• Thyroid Stimulating Hormone (TSH) – This hormone is produced by the pituitary gland. It is used to evaluate thyroid function.

• Free T4 – This hormone is produced by the thyroid gland. It helps regulate metabolism.

• Free T3 – This hormone is produced by the thyroid gland. It helps regulate metabolism.

• Thyroid Peroxidase Antibodies (TPO) – This test measures antibodies directed against thyroid peroxidase. It is used to diagnose autoimmune thyroid diseases, such as Hashimoto's Thyroiditis.

• Thyroglobulin Antibody (TgAb) – This test measures antibodies directed against thyroglobulin. It also monitors autoimmune thyroid diseases, such as Grave's Disease.

  • Antithyroglobulin Antibody Test
  • ATA Test
  • Thyroglobulin Antibody Test

The anti-thyroglobulin antibody test is a blood test that detects the presence of antibodies against thyroglobulin, a protein produced by the thyroid gland. It is used to diagnose and monitor autoimmune thyroid diseases and assess antibody presence in thyroid cancer patients.

The anti-thyroglobulin antibody test detects the presence and concentration of antibodies against thyroglobulin in the blood. These antibodies indicate an immune response against the thyroid gland and can be associated with autoimmune thyroid diseases or interfere with thyroglobulin measurements in thyroid cancer follow-up.

Positive results indicate the presence of anti-thyroglobulin antibodies, suggesting autoimmune thyroid diseases like Hashimoto's thyroiditis or Graves' disease. In thyroid cancer patients, positive TgAb levels can complicate Tg level interpretation. Negative results suggest the absence of these antibodies, making Tg test results more reliable for monitoring thyroid cancer recurrence.


Positive test reports may indicate an autoimmune thyroid disease. In thyroid cancer patients, positive TgAb levels necessitate careful interpretation of Tg results and may require additional testing methods like liquid chromatography tandem mass spectrometry (LC-MS/MS) to accurately measure Tg levels.

The test helps diagnose and manage autoimmune thyroid diseases, provides crucial information for thyroid cancer patient follow-up by identifying potential interference with Tg measurements, and assists in early detection of thyroid cancer recurrence by monitoring changes in TgAb levels.

The test itself is relatively safe, involving a standard blood draw. The primary risks are minor, including pain, bruising, or infection at the needle site. There are no significant long-term risks associated with this test.

This test helps diagnose autoimmune thyroid diseases such as Hashimoto's thyroiditis, Graves' disease, and thyroiditis. It also plays a role in the management and follow-up of thyroid cancer, particularly papillary and follicular thyroid carcinomas.

Certain medications or treatments involving iodine or radioactive iodine can affect thyroid function and potentially influence Tg and TgAb levels. However, there is no direct effect of medications on the accuracy of the TgAb test itself. Inform your healthcare provider about any medications you are taking before the test.

Typically, no special preparation, including fasting, is required before undergoing the anti-thyroglobulin antibody test. However, it is always best to follow any specific instructions provided by your healthcare provider or the laboratory conducting the test.

The presence of other autoantibodies can sometimes interfere with the test results. Recent thyroid surgery or radioiodine ablation may cause a transient rise in TgAb levels. Different assay methods can also yield varying results, especially in the presence of TgAb.

The time to receive the test reports can vary depending on the laboratory and the workload, but generally, results are available after 6 hours after the blood sample is collected.

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