TPMT Enzyme Activity Thiopurine Methyl Transferase Plasma Test in Rajkot

What Does a TPMT Test Measure in Rajkot?

The TPMT Test evaluates how efficiently your body can metabolise thiopurine drugs. It helps your doctor to:

• Assess Thiopurine Drug Metabolism: Determines your ability to process medications like azathioprine or mercaptopurine.
• Prevent Thiopurine Toxicity: Identifies patients at risk of developing bone marrow suppression.
• Guide Medication Dosing: Helps doctors adjust or choose alternate therapies safely.
• Support Personalised Medicine: Optimises treatment based on your individual enzyme activity.
• Monitor Immunosuppressive Therapy: Ensures safe long-term use of thiopurine medications.

Who Should Consider a TPMT Test?

A TPMT Test is recommended for individuals who are:

• About to start treatment with thiopurine drugs (e.g., azathioprine, mercaptopurine, thioguanine).
• Receiving ongoing immunosuppressive therapy for autoimmune diseases like Crohn’s disease, ulcerative colitis, lupus, or rheumatoid arthritis.
• Diagnosed with certain types of leukaemia or other cancers.
• Undergoing organ transplant and prescribed thiopurine-based immunosuppressants.

What Is the Purpose of a TPMT Test?

The primary purpose of the TPMT Test is to help avoid life-threatening side effects caused by standard thiopurine drug doses in people with reduced enzyme activity.

This test allows healthcare professionals to determine whether:

• Standard, reduced, or alternative dosing is needed.
• Thiopurine medications are suitable for your treatment plan.
• Genetic variants affecting TPMT enzyme function are present.

TPMT Test Booking & Reports – Metropolis Healthcare

How To Book a TPMT Test with Metropolis Healthcare in Rajkot?

1. Book Online or Visit a Lab
   Schedule your TPMT Test through the Metropolis Healthcare website or mobile app, or visit your nearest Metropolis Lab in Rajkot.
2. Home Sample Collection
   A trained technician collects your blood sample from home in a sterile EDTA vacutainer. All biosafety and hygiene protocols are followed.
3. Advanced Laboratory Testing
   Your sample is analysed at a NABL & CAP accredited Metropolis Lab using Enzyme Immunoassay (EIA) to determine TPMT enzyme activity.
4. Quick Report Access
   Receive your reports via email, WhatsApp, or download them directly from the Metropolis Healthcare website or app.

How Long Does It Take to Get the TPMT Test Report from Metropolis Healthcare in Rajkot?

Reports are generally available on the same day once the sample reaches the Metropolis Lab.
Note: Reporting time and cost may vary based on your location.

Where Can You View or Collect Your TPMT Test Results?

You can access your results through:

• The Metropolis Healthcare website or mobile app.
• Email or WhatsApp delivery.
• Collection of a printed copy from your nearest Metropolis Lab in Rajkot.

Is Home Sample Collection Available for the TPMT Test in Rajkot?

Yes, Metropolis Healthcare offers home sample collection for the TPMT Test in Rajkot.

Our skilled phlebotomists visit your home at a convenient time, ensuring a smooth and safe blood collection experience.

Guide to Interpreting TPMT Test Results

What Your TPMT Test Results May Indicate

Understanding Abnormal TPMT Test Results

Low enzyme activity may indicate:

• Homozygous TPMT deficiency (risk of life-threatening myelosuppression).
• Need for dose reduction or alternate therapy.

Intermediate enzyme activity may indicate:

• Heterozygous deficiency (partial enzyme function).
• Increased monitoring and adjusted dosing required.

Normal enzyme activity may indicate:

• Normal TPMT gene type (wild-type).
• Standard thiopurine dosing usually safe with routine monitoring.

What Preparations Are Needed for a TPMT Test?

To ensure accurate results, please follow these guidelines:

• No fasting required: You can eat and drink normally before the test.
• Inform your doctor: Share a list of medications, especially if you are on thiopurine-based drugs.
• Clinical history: Must be provided along with the test request form.
• Stay hydrated: Drink water as usual.
• Avoid strenuous exercise or stress: These do not directly affect results but may impact comfort during blood draw.

TPMT Test Price in Different Cities

The cost of a TPMT Test may vary depending on your location. Here's a table showing the approximate price range for the TPMT Test at Metropolis Healthcare in major Indian cities:

The TPMT Test cost may vary depending on the city and the specific tests included in the panel. However, Metropolis Healthcare offers competitive TPMT Test prices across major cities in India.

References

1. Relling M.V., et al. (2019). Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for thiopurine methyltransferase (TPMT) genotype and thiopurine dosing. Clinical Pharmacology & Therapeutics, 105(5), 1095–1105. PMID: 30561839
2. Weinshilboum R.M., et al. (2010). Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase. Drug Metabolism and Disposition, 38(3), 377–387. PMID: 20031229
3. Lennard L. (2014). TPMT in the treatment of Crohn’s disease and acute lymphoblastic leukaemia. British Journal of Clinical Pharmacology, 78(4), 703–714. PMID: 24597782
4. Colombel J.F., et al. (2016). Effect of TPMT activity on adverse events and efficacy in thiopurine therapy. Gut, 65(8), 1391–1399. PMID: 26283809
5. Hindorf U., et al. (2020). Thiopurine therapy in inflammatory bowel disease and pharmacogenetics: a review. Therapeutic Advances in Gastroenterology, 13, 1756284820974914. PMID: 33343382