HLA typing DQ locus Class II Test in Pondichery
Celiac disease (CD) is a multifactorial immune-mediated disease.Specific HLA-DQ genes have been recognized as necessary factors for the occurrence of Celiac Disease (CD).
This test is done to rule diseases strongly linked to DQ locus. For e.g., coeliac disease, narcolepsy
Performed for patients suspected of having diseases strongly associated with the HLA-DQ locus for e.g. coeliac disease
Celiac disease (CD) is a multifactorial immune-mediated disease.Specific HLA-DQ genes have been recognized as necessary factors for the occurrence of Celiac Disease (CD). This test provides genotyping for detection of HLA-DQ2 (DQA1*05:01 or 05:05 and DQB1*02:01 or 02:02) and HLA-DQ8 (DQB1*03:02). The HLA-DQB1*02:01 allele is present in more than 90% CD children. In the perspective of a widened pediatric population screening for CD, a double-step process might be suggested: HLA-DQB1*02:01 might be investigated first and, only if this result is positive, children might be candidate for a prospective serologic screening, as a second step
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