NIPT Advance Test

What does the NIPT Advance Test measure?

The NIPT Advance Test screens for various chromosomal conditions that could affect your baby's health:

• Common trisomies - Extra copies of chromosomes 21 (Down syndrome), 18 (Edwards syndrome), and 13 (Patau syndrome)
• Sex chromosome aneuploidies - Abnormal numbers of X and Y chromosomes, including conditions like Turner syndrome and Klinefelter syndrome
• Autosomal aneuploidies - Chromosomal abnormalities across all other chromosomes (1-22)
• Foetal fraction assessment - The percentage of foetal DNA present in maternal blood
• Risk assessment - Probability calculations for each screened condition using Z-scores and reference intervals

NIPT Advance Test: Who Needs It and Why It's Done

What Symptoms May Call for a NIPT Advance Test?

The NIPT Advance Test is not based on maternal symptoms but rather on risk factors and previous test findings that may indicate increased health risk:

• Abnormal results from earlier screening tests like dual marker or quadruple marker tests
• Concerning findings on foetal ultrasound showing physical markers associated with chromosomal conditions
• Family history of chromosomal abnormalities
• Previous pregnancy affected by chromosomal conditions

Who should get a NIPT Advance Test?

Doctors may recommend the NIPT Advance Test for various groups of pregnant women:

• Women of advanced maternal age (35 years or older at delivery)
• High-risk pregnancies based on family history or previous affected pregnancies
• All pregnant women as a screening option, regardless of risk level
• Women with abnormal results from other prenatal screening tests
• Pregnancies between 10-17 weeks of gestation for optimal accuracy

Why is a NIPT Advance Test done?

The NIPT Advance Test provides a highly accurate, safe method to assess chromosomal abnormality risk early in pregnancy, helping you and your doctor make informed decisions about further testing and pregnancy management.

Importance of a NIPT Advance Test

The NIPT Advance Test represents the most accurate prenatal screening available, with over 99% detection rate for Down syndrome. Unlike invasive procedures like amniocentesis, this blood test carries no risk of miscarriage while providing comprehensive chromosomal screening.

The test's high accuracy significantly reduces false-positive results, meaning fewer women need unnecessary invasive procedures. Early detection at 10 weeks allows for timely decision-making and appropriate pregnancy management. The advanced version screens all chromosomes, providing broader coverage than standard NIPT tests, supporting comprehensive genetic counselling and informed reproductive choices.

NIPT Advance Test Booking & Reports – Metropolis Healthcare India

How to Book a NIPT Advance Test?

1. Simple Online Booking
   Booking can be done through the Metropolis Healthcare app or website. Select NIPT Advance Test, choose a convenient time slot, and provide your address for a blood test at home. You can also visit the nearest Metropolis Lab if you prefer to give the sample directly at the lab.
2. Safe Home Sample Collection
   Our trained phlebotomists ensure timely collection of your sample while strictly following all safety and hygiene protocols.
3. Sample Tracking Updates
   Stay informed at every step. From collection to testing, you can track your sample directly through the Metropolis Healthcare website.
4. Accurate Laboratory Testing
   Your sample is processed at our NABL & CAP accredited laboratories, where expert technicians ensure accurate results.
5. Quick & Easy Reports
   Receive your test reports promptly via email, WhatsApp, or by downloading them directly from the Metropolis Healthcare website or app.

Is home sample collection for NIPT Advance Test available near you?

Yes, home blood sample collection for the NIPT Advance Test is available at Metropolis Healthcare, bringing convenience directly to your doorstep. Our trained phlebotomists follow strict safety protocols while collecting your blood sample in the comfort of your home. This service eliminates the need to travel to a pathology lab.

How Long Does It Take to Get a NIPT Advance Test Report?

Reports are usually available after 8 days after 6:00 PM once the sample reaches the lab.

Where can I see or get NIPT Advance Test results?

Test results from Metropolis Healthcare can be accessed through multiple convenient channels. You can log in to the Metropolis website using your credentials or use the Metropolis Healthcare app to view and download your reports. Additionally, test reports are sent via email or WhatsApp and you also have the option to collect a physical copy directly from the lab.

Interpreting NIPT Advance Test Results

What Your NIPT Advance Test Results May Indicate

The following table explains how to understand your NIPT Advance Test results and their clinical significance:

Conditions that May Affect NIPT Advance Test Accuracy

Several factors can influence your NIPT Advance Test results and should be discussed with your doctor:

• Maternal health conditions including cancer, recent blood transfusion within 12 months, organ transplant, or stem cell therapy can affect results
• Multiple pregnancies (twins) may have slightly lower accuracy due to multiple sources of foetal DNA
• Vanished twin syndrome can confound results with residual DNA from the lost twin
• Confined placental mosaicism where chromosomal abnormalities exist only in the placenta, not the foetus
• Maternal chromosomal abnormalities or mosaicism can interfere with accurate foetal assessment
• Low foetal fraction (insufficient foetal DNA in maternal blood) may require repeat testing
• Certain medications particularly blood thinners like heparin may interfere with analysis
• Technical limitations during sample processing or analysis may occasionally require repeat collection

How is a NIPT Advance Test Done?

The NIPT Advance Test follows a standard blood collection procedure to ensure accurate results:

• A healthcare professional cleans the area on your arm with an antiseptic.
• An elastic band is tied around your upper arm to make the veins more visible.
• A small needle is inserted into a vein to collect small amount of blood.
• The blood sample is collected in a gel vacutainer tube.
• The needle is removed and a bandage is applied to the puncture site.
• Your sample is labelled and sent to the laboratory for analysis.
• The entire procedure takes only a few minutes and causes minimal discomfort.

How Should You Prepare for a NIPT Advance Test?

Preparing for your NIPT Advance Test requires minimal steps but some important documentation:

• No fasting required - You can eat and drink normally before the test
• Bring required documents - Ensure you have completely filled NIPS forms, consent form with clinician's stamp, ultrasound report, and photo identification
• Bring previous test reports - Carry dual marker and quadruple marker test results if available
• Inform about medications - Tell your doctor about any blood thinners or medications you're taking
• Wear comfortable clothing - Choose clothes that allow easy access to your arm

Diseases that a NIPT Advance Test Can Help Detect

The NIPT Advance Test screens for several important chromosomal conditions:

• Down syndrome (Trisomy 21) - Most common chromosomal condition causing intellectual disability

• Edwards syndrome (Trisomy 18) - Serious condition affecting multiple organ systems

• Patau syndrome (Trisomy 13) - Severe chromosomal disorder with multiple birth defects

• Turner syndrome - Affects female development due to missing or incomplete X chromosome

• Klinefelter syndrome - Affects male development due to extra X chromosome

• Triple X syndrome - Extra X chromosome in females

• Jacob's syndrome - Extra Y chromosome in males

• Other autosomal aneuploidies - Abnormalities in chromosomes 1-22

NIPT Advance Test/Packages that You Can Book With Metropolis Healthcare

The following table shows related prenatal screening tests available at Metropolis Healthcare:

NIPT Advance Test Prices in Different Cities

The cost of a NIPT Advance Test may vary depending on your location. Here's a table showing the approximate prices in different cities: