MPL W515/S505 Mutation Analysis, Bone Marrow

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Overview

The MPL gene, also known as the myeloproliferative leukaemia virus oncogene, plays a crucial role in regulating the production of blood cells in the bone marrow. Mutations or alterations in the MPL gene can lead to various blood disorders. The "MPL W515/S505 Mutation Analysis, Bone marrow" test is used to detect mutations in the MPL gene, specifically in Codon W515 and Codon S505. Its clinical utility lies in suspected cases of essential thrombocythemia (ET) and primary myelofibrosis (PMF) where the presence of the Jak2 V617F mutation is negative. Essential thrombocythemia and primary myelofibrosis are myeloproliferative neoplasms characterized by abnormal blood cell production. The Jak2 V617F mutation is commonly associated with these conditions, but in some cases, it may not be present, leading to diagnostic uncertainty. In such situations, testing for MPL mutations in Codon W515 and Codon S505 in bone marrow samples becomes crucial, as detecting these mutations can confirm the diagnosis of ET or PMF. Identifying MPL mutations provides valuable diagnostic information, enabling accurate classification and management of these hematological disorders.

MPL W515/S505 Mutation Analysis, Bone Marrow Price

Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the MPL W515/S505 Mutation Analysis, Bone Marrow with a clear pricing structure.

The MPL W515/S505 Mutation Analysis, Bone Marrow Price in Mumbai is ₹ 6,460 .

We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.

Frequently Asked Questions

What does MPL W515/S505 Mutation Analysis measure?

This test analyzes specific mutations in the MPL gene, specifically in codons W515 and S505. These mutations play a significant role in the development of ET and PMF.

Why is MPL W515/S505 Mutation Analysis done?

• To diagnose essential thrombocythemia (ET) and primary myelofibrosis (PMF) • To confirm the presence of MPL gene mutations • To determine the appropriate treatment approach for patients with suspected ET or PMF • To monitor treatment response and disease progression in ET and PMF

When is MPL W515/S505 Mutation Analysis recommended and who should take the test?

This test is recommended for individuals who • show symptoms suggestive of ET or PMF, such as unexplained blood clotting or bleeding, enlarged spleen, or abnormal blood counts, • have a negative Jak2 V617F mutation result but still present clinical suspicion of ET or PMF, or • require confirmation of the diagnosis for appropriate treatment planning.

What if the results of the MPL W515/S505 Mutation Analysis are abnormal?

The presence of MPL gene mutations suggests a higher likelihood of essential thrombocythemia or primary myelofibrosis. However, abnormal results do not confirm the diagnosis on their own.

What to expect during the MPL W515/S505 Mutation Analysis?

During this test, a bone marrow sample of 3–5 ml is collected using a needle. The sample is sent to the laboratory for analysis using Sanger sequencing.

What preparations are required before the MPL W515/S505 Mutation Analysis?

• Inform your doctor about any medication you are taking. Also, tell them if you have any specific requirements. • No specific dietary or lifestyle preparations are required.

What other tests may be ordered with MPL W515/S505 Mutation Analysis?

• Jak2 V617F Mutation Analysis: This test helps differentiate between Jak2 and MPL gene mutations in patients suspected of having ET or PMF. • Complete Blood Count (CBC): This blood test provides information about the overall health of the blood, including red and white blood cell counts.

What is the MPL W515/S505 Mutation Analysis also known as?

MPL Gene Mutation Analysis or MPL Gene Sequencing

What is essential thrombocythemia (ET) and primary myelofibrosis (PMF)?

Essential thrombocythemia (ET) is a blood disorder characterised by the overproduction of platelets, leading to an increased risk of blood clots. Primary myelofibrosis (PMF) is a condition where abnormal bone marrow leads to the formation of scar tissue, disrupting healthy blood cell production.

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