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JAK-2 Mutation (CMPD) Exon 12 Mutation Bone Marrow
Also known as: JAK2 Exon 12 Mutation Detection, EDTA Bone Marrow
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
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Overview
The JAK2 Mutation (CMPD) Exon 12 Mutation test performed on bone marrow samples is clinically useful in suspected cases of Polycythemia Vera (PV) where the Jak2 V617F mutation is negative. Polycythemia Vera is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. While the Jak2 V617F mutation is the most common mutation associated with PV, there are rare cases where this mutation is not detected. In such situations, the JAK2 Exon 12 Mutation test is indicated for confirmation of PV. This test specifically examines mutations in exon 12 of the JAK2 gene to identify any alternative genetic abnormalities that may be responsible for PV. By detecting these specific mutations, the JAK2 Exon 12 Mutation test aids in confirming the diagnosis of PV and guiding appropriate treatment decisions for affected individuals.
JAK2 Exon 12 Mutation Detection, EDTA Bone Marrow Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the JAK2 Exon 12 Mutation Detection, EDTA Bone Marrow with a clear pricing structure.
The JAK2 Exon 12 Mutation Detection, EDTA Bone Marrow Price in Thane is ₹ 6,890 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
The JAK-2 Mutation (CMPD) Test detects the presence of JAK-2 gene mutations in exon 12 in the bone marrow.
• To confirm a diagnosis of polycythemia vera when other tests are inconclusive • To identify specific genetic mutations in the JAK-2 gene, which are associated with this condition • To differentiate polycythemia vera from other similar blood disorders
The JAK-2 Mutation (CMPD) Test may be recommended if you have symptoms such as fatigue, weakness, headaches, or vision problems that suggest polycythemia vera. It is also suggested if other initial screening tests for polycythemia vera are inconclusive or if you have risk factors or a family history of the condition.
Abnormal results suggest the presence of mutations associated with polycythemia vera.
During the test, your doctor will draw a bone marrow sample from your hip bone. They will send the sample to the laboratory for testing.
• Your doctor may ask you to stop taking blood-thinning medications before the test. • Inform your doctor about any other medications or supplements you are taking. Also, tell them if you have any specific requirements. • Follow any additional instructions provided by your doctor regarding fasting or other dietary restrictions before the test.
• Complete Blood Count (CBC): This test measures various components of your blood, such as red blood cells, white blood cells, and platelets. • Bone Marrow Biopsy: In this procedure, a small sample of bone marrow is collected for examination under a microscope to evaluate its cellular composition. • Genetic Testing for Other Mutations: Additional genetic tests may be ordered to rule out other potential genetic mutations related to blood disorders.
Jak2 V617F Mutation Test
Polycythemia vera is a rare blood disorder characterised by the overproduction of red blood cells, white blood cells, and platelets in the bone marrow. It is usually caused by a mutation in the JAK-2 gene. This condition can lead to an increased risk of blood clots and other complications.
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