Karyotyping G Banding and FISH (Chr 13,18, 21, X and Y), Amniotic Fluid

Examining chromosomes in the amniotic fluid (the fluid surrounding the foetus in the womb during pregnancy) can help detect abnormalities and identify conditions like Down syndrome, Edwards syndrome, Patau syndrome, and sex chromosome abnormalities. Karyotyping with G-Banding and FISH (Fluorescence In Situ Hybridization) for chromosomes 13, 18, 21, X, and Y is performed on amniotic fluid samples as a comprehensive diagnostic test. This combined approach allows for a detailed analysis of the chromosomes, providing valuable information about potential chromosomal abnormalities in prenatal cases. To ensure accurate and meaningful results, it is important to submit a detailed clinical history, including the anomaly scan report, along with the sample. Additionally, a consent form that adheres to the guidelines of the Pre-Conception and Pre-Natal Diagnostic Techniques (PCPNDT) must be duly signed and provided. The integration of karyotyping with G-Banding and FISH techniques enables healthcare professionals to effectively identify and evaluate chromosomal anomalies, facilitating appropriate counseling and support for expectant parents.